Formosan Journal of Musculoskeletal Disorders最新文献

{"title":"Ischemic diseases of the hip; osteonecrosis, borderline necrosis and bone marrow edema syndrome","authors":"J. Yoo, C. H. Park, Y. Ha, Young-Kyun Lee, K. Koo","doi":"10.6492/FJMD.20151215","DOIUrl":"https://doi.org/10.6492/FJMD.20151215","url":null,"abstract":"There is general consensus about the etiology and pathogenesis of femoral head osteonecrosis (ON): ON has a multifactorial etiology, genetic predispositions and acquired risk factors play role together in the pathogenesis of most cases, and both of marrow mechanism and intravascular mechanism are involved in the pathogenesis. There is an ischemic threshold between reversible intraosseous hypoxia, which leads to bone marrow edema syndrome or borderline necrosis, and irreversible intraosseous anoxia, which leads to osteonecrosis.","PeriodicalId":100551,"journal":{"name":"Formosan Journal of Musculoskeletal Disorders","volume":"9 1","pages":"145-152"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77974170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long term follow-up of transtrochanteric rotational osteotomy in patients with extensive and collapsed femoral head osteonecrosis","authors":"Cheng-Ta Wu, Feng-Chih Kuo, Tsan-Wen Huang, S. Ueng, Mel S. Lee","doi":"10.6492/FJMD.20151224","DOIUrl":"https://doi.org/10.6492/FJMD.20151224","url":null,"abstract":"Background: Transtrochanteric rotational osteotomy (TRO) potentially can salvage hips with extensive and collapsed lesions of femoral head osteonecrosis (ONFH). However, the results varied greatly and few long term results were reported. Methods From 1998 to 2001, TRO had been done on 15 ONFH hips. The mean age of the patients was 42 years. All hips were associated with extensive lesions and in the early collapsed stage (ARCO staging system, IIIA less than 2 mm collapse in 10 hips and IIIB 2 to 4 mm collapse in 5 hips). Demographic data, Harris hip score, and radiological outcomes were reviewed. Results: Anterior rotational osteotomy was done in 11 hips and posterior rotational osteotomy was done in 4 hips. The index of necrosis was 39% in average (range, 12% to 68%). In the 15 hips with an average follow-up of 11 years, the Harris hip score improved from 39.1 to 76.2. Six hips were converted to total hip replacement in an average of 3.6 years. The overall survival rate for conversion to total hip replacement as the end point was 60%. The overall radiological success rate was 53.3% Conclusions: TRO is a worthy procedure to preserve extensive and collapsed hips with acceptable success rate. Technical difficulties while executing the surgery or converting to total hip replacement should be considered and discussed fully with the patients.","PeriodicalId":100551,"journal":{"name":"Formosan Journal of Musculoskeletal Disorders","volume":"8 1","pages":"169-175"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81722070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining lesion size in osteonecrosis of the femoral head: A practical approach","authors":"M. Steinberg, S. C. Oh, V. Khoury, J. Udupa, D. Steinberg","doi":"10.6492/FJMD.20161201","DOIUrl":"https://doi.org/10.6492/FJMD.20161201","url":null,"abstract":"Background: To provide the best possible evaluation and treatment for patients with osteonecrosis of the femoral head (ONFH) it is necessary to determine the size of the necrotic lesion and extent of joint involvement as well as the stage. There has been a steady trend towards the use of comprehensive classifications, but there remains a difference of opinion as how best to determine lesion size. Purpose: To determine the accuracy and ease of use of various angular measurements and other techniques for measuring lesion size in ONFH. Methods: Eighteen hips with Stage I, II ONFH were evaluated using three-dimensional MRI measurements of lesion volume as the standard against which to compare simple visual estimates and area and angle measurements on plain radiographs and MRI. Results: The necrotic region occupied between 2.2% and 59% of the femoral head volume on MRI measurements. Many plain films in this specific series did not depict the lesion margins well, which made delineation, estimation and measurements of lesion size less accurate than in previous studies. There was a rough correlation between angle measurements and lesion size. This correlation was closer with the Index of Necrosis than with the Combined Necrotic Angle, which routinely overestimated size. The accuracy of the Index was improved when adjusted to reflect a femoral head angle of 250 degrees rather than 180 degrees. Numerical limits were derived with which angular measurements could be correlated for 70% of hips with Grades 〞A〞, 〞B〞 and 〞C〞 lesion size, as described in the University of Pennsylvania and ARCO classifications. Simple visual estimates from MRI studies were as accurate as angular measurements. Conclusions: For routine clinical use, visual estimates from good quality radiographs or MRI are generally satisfactory. Angular measurements do give an indication of prognosis and treatment, although they are estimates rather than true measurements of lesion size. 3-D MRI volume measurements are the most accurate method of measuring lesion size. They are now easier to use and should be considered for research and publications.","PeriodicalId":100551,"journal":{"name":"Formosan Journal of Musculoskeletal Disorders","volume":"54 1","pages":"153-160"},"PeriodicalIF":0.0,"publicationDate":"2016-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84712611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteonecrosis repair with stem cells: 30 years of experience from bone marrow concentration to cultured mesenchymal stem cells","authors":"P. Hernigou, C. Flouzat-Lachaniette, C. Bouthors, F. Roubineau, N. Chevallier, H. Rouard","doi":"10.6492/FJMD.20160126","DOIUrl":"https://doi.org/10.6492/FJMD.20160126","url":null,"abstract":"Mesenchymal stem cells (MSCs) comprise a mixture of various stem cells in myeloid tissue with multipotential differentiation capacity. They can differentiate into bone cells under specific conditions and can be used to treat Osteonecrosis of the femoral head (ONFH) through cell transplantation. This review summarizes research on MSCs in the field of ONFH performed by our team, reveals the progress realized the last 30 years, describes their potential to treat osteonecrosis disease, and analyzes some existing challenges of using MSCs in clinical applications.","PeriodicalId":100551,"journal":{"name":"Formosan Journal of Musculoskeletal Disorders","volume":"3 1","pages":"127-137"},"PeriodicalIF":0.0,"publicationDate":"2016-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88806901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem cell therapy for early stage osteonecrosis: challenges and future research directions","authors":"Austin M. Looney, Abhijit S. Dighe, W. Novicoff, Q. Cui","doi":"10.6492/FJMD.20161130","DOIUrl":"https://doi.org/10.6492/FJMD.20161130","url":null,"abstract":"Over the past decade, several clinician researchers have started to evaluate the role of Mesenchymal stem cells (MSCs) in treatment of osteonecrosis (ON). Gangji et al. and Hernigou et al. have successfully used autologous bone marrow concentrate for treatment of early stage ON. Both investigators have reported midto long-term favorable results. However, contradictory results were also reported using similar techniques and patient populations. In addition, many questions are yet unanswered and only limited information is available in the literature in terms of clinical trials and surgical techniques in humans using MSCs as adjunct therapies. This manuscript will review literatures related to MSCutilizing surgical techniques and explore some of the limitations and future research directions of using stem cell therapies in osteonecrosis.","PeriodicalId":100551,"journal":{"name":"Formosan Journal of Musculoskeletal Disorders","volume":"2 1","pages":"119-126"},"PeriodicalIF":0.0,"publicationDate":"2016-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72926365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing lateral tibial plateau fractures by reversed 3.5 mm buttress plate: A report of four cases","authors":"Yueh-Ying Hsieh, Lien-Chen Wu, Chang-Jung Chiang, Y. Tsuang, Chen Chia-Hsien","doi":"10.6492/FJMD.20151110","DOIUrl":"https://doi.org/10.6492/FJMD.20151110","url":null,"abstract":"Osteonecrosis is a common disorder of bone, which if left untreated, will lead to progressive collapse of bone, and degeneration of the overlying articular cartilage. Recently, new techniques have been developed in which the osteonecrotic lesion is drilled (core decompression) and/or more extensively debrided, and osteoprogenitor cells from the iliac crest are harvested, concentrated and delivered to the lesion to enhance bone healing. In the earlier stages of osteonecrosis of the hip and knee without collapse or arthritic changes in the involved joint, the intermediate term results for preserving (rather than replacing) the joint using these techniques have been very encouraging. Future basic and clinical research is necessary to develop evidence-based algorithms to optimize patient selection, cell harvesting, expansion and delivery, preparation of the osteonecrotic lesion, biomechanical support and appropriate rehabilitation protocols.","PeriodicalId":100551,"journal":{"name":"Formosan Journal of Musculoskeletal Disorders","volume":"27 1","pages":"104-107"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86725830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The combination of mesoporous bioactive glass with fibrin and antibiotic for bone regeneration","authors":"Lei-Yen Chen, Wei-Chuan Chen, Hsia-Wei Liu, Hsiao-Mei Lin, Hsien-Tao Liu, Chih‐Hwa Chen","doi":"10.6492/FJMD.20150531","DOIUrl":"https://doi.org/10.6492/FJMD.20150531","url":null,"abstract":"Background: A mesoporous bioactive glass (MBG) with a highly specific surface area and well-ordered pores is a suitable material to carry antibiotics. Fibrin and mesenchymal stem cells are used in promoting tissue repair and osteogenesis, respectively. Purposes: Tobramycin-loaded mesoporous bioactive glass (TMBG), fibrin and mesenchymal stem cells are used in this study to promote osteogenesis and against bacterial contamination in vitro. Methods: MBG was synthesized in a two-step acid-catalyzed self-assembly process with hydrothermal treatment. Tobramycin was loaded with MBG and fibrin to make a TMBG fibrin complex. The cell proliferation, osteogenic differentiation, Live/Dead staining and antibiotics inhibition zone test were evaluated for TMBG fibrin complex. Results: The experimental results showed a well-ordered hexagonally structured bioactive glass was synthesized. The TMBG fibrin complex cultivated with rabbit bone marrow mesenchymal stem cells (RBMSCs) showed good biocompatibility and increased expression of collagen type I, OPN, OCN and RUNX2 in cultivation period. The inhibition zone of TMBG fibrin complex increased while the concentration of tobramycin increased against Staphylococcus aureus and Pseudomonas aeruginosa. In addition, the TMBG fibrin complex (with 0.5% tobramycin) had the same antibacterial effect as 10 mg tobramycin. Conclusions: Based on the results mentioned above, the TMBG fibrin complex showed antibacterial effect and exhibited great biocompatibility a potential biomaterial for bone tissue engineering.","PeriodicalId":100551,"journal":{"name":"Formosan Journal of Musculoskeletal Disorders","volume":"9 1","pages":"69-78"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78527480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time human tenocytes proliferation and responses to anesthetics and NSAIDs in microfluidic culture system","authors":"C. Chiu, A. Chen, K. Lei","doi":"10.6492/FJMD.20150610","DOIUrl":"https://doi.org/10.6492/FJMD.20150610","url":null,"abstract":"","PeriodicalId":100551,"journal":{"name":"Formosan Journal of Musculoskeletal Disorders","volume":"63 1","pages":"79-89"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75882040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A long sequestered lumbar disc with tumor appearance and another minor one migrated caudally in an aged patient: A case report","authors":"L. Yang, Y. Chien","doi":"10.6492/FJMD.20151117","DOIUrl":"https://doi.org/10.6492/FJMD.20151117","url":null,"abstract":"A large sequestered disc with tumor appearance was extremely rare. If combined with another migrated fragment and happened in a very aged patient, to the best of our knowledge, it was never reported in the literature. We reported a case of 85-year-old female patient who suffered from severe low back pain and right sciatica after lumbar sprain for 1 month and aggravated for 5 days. Magnetic resonance imaging demonstrated a long longitudinal tumor-like lesion, extending from L2-3 to L3-4 anterior epidural space and occupying about anterior one third of the vertebral canal. Besides, there was another tumor like lesion located at the right L3-4 lateral foramen. The pathological report for both lesions turned out to be sequestrated disc fragments.","PeriodicalId":100551,"journal":{"name":"Formosan Journal of Musculoskeletal Disorders","volume":"33 1","pages":"108-111"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77374876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A non-traumatic stress fracture of the tibial plateau following a marathon race: A rare case report","authors":"Jin-wei Wang, Huaan-Min Chiu","doi":"10.6492/FJMD.20150714","DOIUrl":"https://doi.org/10.6492/FJMD.20150714","url":null,"abstract":"In recent years, the number of sports injuries in Taiwan has increased owing to a dramatic increase in the popularity of running marathons. Most tibial stress fractures occur at the posteromedial aspect of the middle third of the tibial shaft, and other less common sites of this fracture are the anterior cortex and medial malleolus. Here we report a 59-year-old man with a stress fracture located in an unusual region -- the tibial plateau, following a marathon race. The patient presented with anterior knee pain and had ＂negative＂ radiographs. Magnetic resonance imaging showed a stress fracture of the proximal tibia and partial tears of the anterior cruciate ligament, posterior cruciate ligament, and medial collateral ligament. He was treated conservatively considering the appropriate alignment of the fracture without any displacement. A long-leg splint was used, and no weight bearing was allowed on the affected leg for 9 weeks. Healing was monitored with a series of follow-up radiographs that showed sclerosis with endosteal change over the proximal tibia. The fracture eventually healed without any complications. Orthopedic surgeons should consider the possibility of a tibial plateau fracture in the context of non-traumatic knee pain after a marathon race or other high-loading activity, even if radiographs do not demonstrate a fracture. This will help in the early diagnosis and treatment of this stress fracture.","PeriodicalId":100551,"journal":{"name":"Formosan Journal of Musculoskeletal Disorders","volume":"50 1","pages":"99-103"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75819181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}