Chiang Mai University journal of natural sciences最新文献_第3页

Effect of Immersion Time in Simulated Body Fluid on Adhesion Strength of Hydrothermally Treated Hydroxyapatite-Titanium Nitride Films on Polyetheretherketones 模拟体液浸泡时间对水热处理羟基磷灰石-氮化钛膜与聚醚醚酮黏附强度的影响

Chiang Mai University journal of natural sciences Pub Date : 2022-07-11 DOI: 10.12982/cmujns.2022.042

Kwanchanok Koonrungsesomboon, D. Boonyawan, Kullapop Suttiat, Piriya Yavirach

{"title":"Effect of Immersion Time in Simulated Body Fluid on Adhesion Strength of Hydrothermally Treated Hydroxyapatite-Titanium Nitride Films on Polyetheretherketones","authors":"Kwanchanok Koonrungsesomboon, D. Boonyawan, Kullapop Suttiat, Piriya Yavirach","doi":"10.12982/cmujns.2022.042","DOIUrl":"https://doi.org/10.12982/cmujns.2022.042","url":null,"abstract":"Abstract This study sought to investigate the effect of immersion time in simulated body fluid (SBF) on the adhesion strength of hydrothermally treated hydroxyapatite-titanium nitride (HA-TiN) films on polyetheretherketone (PEEK) substrates. The HA-TiN films were deposited on PEEK substrates via magnetron sputtering and annealed with hydrothermal treatment. The crystalline phase and element compositions on the deposited films were confirmed by X-ray diffractometry (XRD), and X-ray photoelectron spectrometry (XPS). The samples were then immersed in SBF at 37°C for 7 to 56 days, where the surface characterization and chemical composition of the films were analyzed using scanning electron microscopy (SEM), atomic force microscopy (AFM), and XPS. After the in vitro degradation in SBF, the adhesion strength between HA-TiN films and PEEK substrates were measured by a universal testing machine and further investigated the failure mode using a stereomicroscope and SEM. The results demonstrated the improvement of crystallinity on HA-TiN sputtered films after hydrothermal treatment. After immersion in SBF, the coating surface revealed some nucleation without any detachment and exhibited an increase of surface roughness. The hydroxyapatite and titanium dioxide were revealed on the surface throughout the 56 days, while the Ca/P ratio decreased and remained constant during immersion. The adhesion strength did not significantly differ in all groups. These findings concluded that hydrothermally treated HA-TiN sputtered films on PEEK substrates showed the stability of adhesion strength throughout 56 days in simulated physiological conditions. The dissolution and precipitation during immersion represented the favorable characteristics of the films in the orthopedic or dental application. Keywords: Adhesion, Degradation, Thin films, Hydroxyapatite, Titanium dioxide","PeriodicalId":10049,"journal":{"name":"Chiang Mai University journal of natural sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42310186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Serological Status of Hepatitis B Virus Infection Among Hill-Tribe Children in Northern Thailand, in 2018 2018年泰国北部山地部落儿童乙型肝炎病毒感染血清学状况分析

Chiang Mai University journal of natural sciences Pub Date : 2022-07-11 DOI: 10.12982/cmujns.2022.037

Yada Aronthippaitoon, Nipatsorn Boonserm, Tunyalak Saming, Sucheewa Udomsilp, S. Choyrum, S. Hongjaisee, J. Yanola, N. Ngo-Giang-Huong, S. Pornprasert, W. Khamduang

{"title":"Serological Status of Hepatitis B Virus Infection Among Hill-Tribe Children in Northern Thailand, in 2018","authors":"Yada Aronthippaitoon, Nipatsorn Boonserm, Tunyalak Saming, Sucheewa Udomsilp, S. Choyrum, S. Hongjaisee, J. Yanola, N. Ngo-Giang-Huong, S. Pornprasert, W. Khamduang","doi":"10.12982/cmujns.2022.037","DOIUrl":"https://doi.org/10.12982/cmujns.2022.037","url":null,"abstract":"Abstract Thailand has integrated Hepatitis B (HB) vaccine for newborns into the national Expanded Program on Immunization since 1992. The HB vaccination coverage was reported >96% in 2019 but the coverage among inhabitants of remote rural areas, particularly among hill-tribe children, remains unclear. This cross-sectional study aims to investigate the hepatitis B virus (HBV) seroprevalence among hill-tribe children living in 3 different areas in Omkoi District, Chiang Mai province, Thailand during September-November, 2018. Plasma samples were first tested for hepatitis B surface antigen (HBsAg). Sample negative for HBsAg were then tested for antibody to hepatitis B surface antigen (anti-HBs) levels and antibody to hepatitis B core antigen (anti-HBc). A total of 419 hill-tribe children were recruited, their median age was 11 years (interquartile range 9-12 years). Eighteen children (4.3%, 95%CI 2.6-6.7) were HBsAg positive. Among 401 remaining children, 269 had no HBV markers (67.1%, 95%CI 62.3-71.7), 91 (22.7%, 95%CI 18.7-27.1) were positive for anti-HBs only, 23 (5.7%, 95%CI 3.7-8.5) were positive for anti-HBc and anti-HBs, and 18 (4.5%, 95%CI 2.7-7.0) positive for anti-HBc only. The high prevalence of children susceptible to HBV infection and the high proportion of HBV infected children indicate that vaccination strategy needs to be improved in this rural area. Moreover, HBV serologic investigations are necessary in other rural areas to improve HB vaccination coverage. Keywords: Hepatitis B virus; Prevalence; Vaccination; Serological markers; Children; Thailand","PeriodicalId":10049,"journal":{"name":"Chiang Mai University journal of natural sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44435162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of 2D Electrical Resistivity and Self-Potential Methods for the Assessment of the Integrity of Goronyo Dam NW Nigeria 尼日利亚西北部Goronyo大坝完整性评估的二维电阻率和自电位方法的相关性

Chiang Mai University journal of natural sciences Pub Date : 2022-07-11 DOI: 10.12982/cmujns.2022.043

Abdulrahaman Idris Augie, M. Saleh, O. Ologe, K. Salako, Adewuyi Abdulwaheed Rafiu, M. Yahaya

{"title":"Correlation of 2D Electrical Resistivity and Self-Potential Methods for the Assessment of the Integrity of Goronyo Dam NW Nigeria","authors":"Abdulrahaman Idris Augie, M. Saleh, O. Ologe, K. Salako, Adewuyi Abdulwaheed Rafiu, M. Yahaya","doi":"10.12982/cmujns.2022.043","DOIUrl":"https://doi.org/10.12982/cmujns.2022.043","url":null,"abstract":"Abstract In this research, combined 2D electrical resistivity and self-potential (SP) methods were employed to locate anomalous electrical conductivity around the Goronyo dam in order to determine the condition of the embankment of the earth dam. The data were taken with the reference to resistivity and SP values using Wenner configuration. The results obtained from these techniques shows that the area was underlain by four stratigraphic layers, namely; clayey sand, wet sandy clay, laterite and partially weathered basement complex rock as compared with the resistivities of common rocks and borehole lithology of the area. The low SP (< 200 mV)/high resistivity zones in the overburden of profiles P1, P2 and P3 shows the presence of partially weathered basement complex rocks which was probably due to compactness and dryness around the dam. However, the zones of high SP (≥ 200 mV)/low apparent resistivity regions (z1 and z2) of profiles P1 (2 Ωm to 27 Ωm), P2 (3 Ωm to 25 Ωm) and P3 (3 Ωm to 14 Ωm) have revealed the weak zones associated with wet sandy soil. Results obtained from 2D electrical resistivity (z1) technique have correlated well with the results of SP sections (z2). These regions of weak zones occupied the x-distance along the profiles; P1/or S2 (120 m to 200 m and 250 m to 400 m), P2/or S2 (1 m to 156 m and 192 m to 400 m) and P3/or S3 (48 m to 400 m) with their corresponding depth y, ranging from 23 m to 30 m, 26 m to 30 m and 23 m to 30 m. Keywords: 2D Electrical Resistivity Tomography (ERT), Self-Potential (SP), Dam, Subsurface, Seepage, Condition","PeriodicalId":10049,"journal":{"name":"Chiang Mai University journal of natural sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43817512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GC/MS Based Metabolite Profiling and Biological Activity of Leaves and Flower Heads of Tanacetum Cinerariifolium (Trevir.) Sch.Bip. 基于GC/MS的柽柳叶和花头代谢谱及生物活性分析Sch.Bip。

Chiang Mai University journal of natural sciences Pub Date : 2022-07-11 DOI: 10.12982/cmujns.2022.038

M. Nikolova, Vladimir Ilinkin, E. Yankova-Tsvetkova, M. Stanilova, S. Berkov

{"title":"GC/MS Based Metabolite Profiling and Biological Activity of Leaves and Flower Heads of Tanacetum Cinerariifolium (Trevir.) Sch.Bip.","authors":"M. Nikolova, Vladimir Ilinkin, E. Yankova-Tsvetkova, M. Stanilova, S. Berkov","doi":"10.12982/cmujns.2022.038","DOIUrl":"https://doi.org/10.12982/cmujns.2022.038","url":null,"abstract":"Abstract Flower heads and leaves of Tanacetum cinerariifolium (Trevir.) Sch. Bip. were examined separately for bioactive compounds and biological activity. The compounds were identified by GC/MS analysis. Studied extracts were evaluated for free radical scavenging activity, and for inhibition of acetylcholinesterase and seed germination. Free phenolic acids and flavonoid aglycones were found in larger quantities in the leaves than in the flower heads, where sterols, fatty acids, pyrethrins, sugars, sugar derivatives and bound phenolic acids predominated. Significant antiradical activity (IC50 /mL) and low acetylcholinesterase inhibitory activity (IC50 >1 mg/mL) was found. Moderate inhibitory activity against germination and root elongation of Lolium perenne L. seeds was determined. The study presents for the first time detailed data on the content of phenolic acids in free, esterified and insoluble-bound forms in this species. Some of the identified flavonoids from the leaf extract are reported for the first time in the species. Keywords: GC/MS, Flavonoids, Phenolic acids, Asteraceae (Composite)","PeriodicalId":10049,"journal":{"name":"Chiang Mai University journal of natural sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44122510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social Cognitive Theory-based Interventions on Healthy Lifestyles for Hypertensive Patients: A Systematic Review 基于社会认知理论的高血压患者健康生活方式干预:系统综述

Chiang Mai University journal of natural sciences Pub Date : 2022-07-11 DOI: 10.12982/cmujns.2022.040

Wachira Suriyawong, Noppamas Pipatpiboon

{"title":"Social Cognitive Theory-based Interventions on Healthy Lifestyles for Hypertensive Patients: A Systematic Review","authors":"Wachira Suriyawong, Noppamas Pipatpiboon","doi":"10.12982/cmujns.2022.040","DOIUrl":"https://doi.org/10.12982/cmujns.2022.040","url":null,"abstract":"Abstract Effective strategies to promote a long-term healthy lifestyle among hypertensive patients remain unclear. Social cognitive theory (SCT)-based interventions have demonstrated some effectiveness in promoting sustainable lifestyle change in this population. This systematic review aims to synthesize randomized controlled trials (RCTs) examining the effect of SCT-based interventions on healthy lifestyles, including physical activity [PA] and/or diet adherence [DA], in hypertensive patients. Four electronic databases (CINAHL, PubMed, Scopus, and Web of Science) were searched to identify RCTs that: 1) targeted hypertensive patients; 2) reported PA and/or DA as proximal outcomes; and 3) included an intervention guided by the SCT. Narrative and tabulation synthesis were conducted to present the effects of the SCT-based interventions. Fifteen studies were included in this systematic review with 3,388 hypertensive patients (mean age = 52.21, 68.70% female). Findings were inconsistent for the SCT-based interventions targeting multiple behaviors, including DA and PA. Multiple-component interventions, including PA training and identification of PA barriers through group discussion, had a greater effect size on PA improvement (d = .93–.99) than interventions without these components (d = .29–.44). Interventions with a longer duration (> 12 weeks), greater length of time for sessions (150 minutes/session), and higher session frequency (2 days/week) were more effective on DA change (d = .65) than interventions with a shorter duration (< 12 weeks), shorter session length (60–90 minutes), or lesser session frequency (monthly meeting) (d = .09–.51). Keywords: Social cognitive theory, Hypertension, Physical activity, Diet adherence","PeriodicalId":10049,"journal":{"name":"Chiang Mai University journal of natural sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47068594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Carbonate Hydroxyapatite (CHA) on the Development of Heart and Cranium Cartilage of Zebrafish (Danio rerio Hamilton, 1882) Larvae 碳酸羟基磷灰石（CHA）对斑马鱼（Danio rerio Hamilton，1882）幼虫心脏和颅骨软骨发育的影响

Chiang Mai University journal of natural sciences Pub Date : 2022-07-11 DOI: 10.12982/cmujns.2022.041

S. Pratama, B. Retnoaji, I. Ana

{"title":"Effects of Carbonate Hydroxyapatite (CHA) on the Development of Heart and Cranium Cartilage of Zebrafish (Danio rerio Hamilton, 1882) Larvae","authors":"S. Pratama, B. Retnoaji, I. Ana","doi":"10.12982/cmujns.2022.041","DOIUrl":"https://doi.org/10.12982/cmujns.2022.041","url":null,"abstract":"Abstract One of the most commonly utilized materials for dental implants is carbonate hydroxyapatite (CHA). However, its usage must be free of tissue toxicity. Therefore, this study aimed to investigate how the use of CHA as a dental implant material affected the development of zebrafish (Danio rerio) embryos. CHA treatment was administered to 3–3.5 hours to 72 hours post-fertilization (hpf) embryos. Alterations in embryo and larva shape were all studied to determine toxicity. Several abnormalities that might arise during development were also examined by monitoring morphological alterations in embryos and larvae. Furthermore, heart morphology in larvae aged 72 hpf; heart rate in embryos aged 24, 48, and 72 hpf; and cardiac histology structure in larvae aged 30 dpf were all used to study heart development. Alizarin Red and Alcian Blue (ARAB) staining was employed to determine the anatomy of the cranial cartilage in larvae aged 6 dpf. Data were statistical analysis with SPSS ver. 21 and the significance was determined using one-way analysis of variance (ANOVA). The morphological examination results revealed that the embryo and larvae had no morphological abnormalities. Furthermore, the heart was developing normally, according to examinations of morphology, histology, and heart rate. The cranial cartilage had no flaws, the structure was complete, and the length and angle of the cranial cartilage did not change between the control and CHA treatments. Overall, CHA exposure did not affect the development of zebrafish (Danio rerio) embryos, according to the findings. Keywords: CHA, Cranium, Embryo, Heart, Toxicity, Zebrafish","PeriodicalId":10049,"journal":{"name":"Chiang Mai University journal of natural sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41326034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Repellent Potential of Herbal Oils Alone and in Combination in Mouse Behavioral Models (Mus musculus) 草药精油单独和联合使用对小鼠行为模型(小家鼠)的驱避作用

Chiang Mai University journal of natural sciences Pub Date : 2022-07-11 DOI: 10.12982/cmujns.2022.049

Yaowared Chulikhit, Juthamart Maneenet, O. Monthakantirat, S. Daodee, Charinya Khamphukdee

{"title":"The Repellent Potential of Herbal Oils Alone and in Combination in Mouse Behavioral Models (Mus musculus)","authors":"Yaowared Chulikhit, Juthamart Maneenet, O. Monthakantirat, S. Daodee, Charinya Khamphukdee","doi":"10.12982/cmujns.2022.049","DOIUrl":"https://doi.org/10.12982/cmujns.2022.049","url":null,"abstract":"Abstract Natural repellent products are of interest worldwide due to their low toxicity, rapid degradation, and being friendly to the environment. The current study evaluated the efficiency of herbal oils from fragrant plants as mouse repellents. Orange oil (Citrus sinensis (L.) Osbeck), peppermint oil (Mentha × piperita L.), lemongrass oil (Cymbopogon citratus (DC.) Stapf), ginger oil (Zingiber officinale Roscoe), plai oil (Zingiber cassumunar Roxb.), menthol and their combination were tested in a radial arm maze and light/dark transition test. For the short-term effect (week 0), each of the herbal oils and their combination were effective as mouse repellents, as shown by increased latency times and decreased time spent in arms containing repellents in the radial arm maze. Similarly, mice exposed to each of the herbal oils and their combination in the dark chamber spent more time in the light chamber in the light/dark transition test. Only peppermint oil and menthol failed to maintain their repellent activity in the long-term effect (week 1). Thus, we recommend spraying orange oil, lemongrass oil, ginger oil, plai oil and the combination of all oils every week for effective mouse repellant activity. Keywords: Medicinal plant, Mice, Natural product, Essential oils, Anxiety","PeriodicalId":10049,"journal":{"name":"Chiang Mai University journal of natural sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42899440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testing the Accuracy of an Age Estimation Method Using Radiographs of Permanent Mandibular Third Molar Teeth in a Thai Population 在泰国人群中使用恒常下颌第三磨牙射线照片测试年龄估计方法的准确性

Chiang Mai University journal of natural sciences Pub Date : 2022-07-11 DOI: 10.12982/cmujns.2022.045

Pornpat Theerasopon, Kanyathorn Tiansuwan, Natthanan Srichaitan, Sichanad Norkaew, Chairat Charoemratrote, N. Srimaneekarn, Phuwadon Duangto

{"title":"Testing the Accuracy of an Age Estimation Method Using Radiographs of Permanent Mandibular Third Molar Teeth in a Thai Population","authors":"Pornpat Theerasopon, Kanyathorn Tiansuwan, Natthanan Srichaitan, Sichanad Norkaew, Chairat Charoemratrote, N. Srimaneekarn, Phuwadon Duangto","doi":"10.12982/cmujns.2022.045","DOIUrl":"https://doi.org/10.12982/cmujns.2022.045","url":null,"abstract":"Abstract The aim of this study was to test the accuracy of an age estimation method using the radiographs of permanent mandibular third molar teeth in a Southern Thai population. Digital panoramic radiographs of 480 Thai samples (240 males and 240 females) aged from 8 to 23 years were selected and divided into 16 age groups. The permanent mandibular third molar teeth were separated into nine developmental stages according to the Demirjian et al. classification. The developmental stage was evaluated and then converted into a developmental score. Accuracy of the dental age estimation was tested using regression equations according to the Duangto et al. study. Our results showed that dental age was close to the chronological age within one year for both sexes. In conclusion, the age estimation equations according to the Duangto et al. study provide an accurate age estimation in a Southern Thai population. Keywords: Dental age estimation, Demirjian et al. classification, Mandibular third molar teeth, Thai population","PeriodicalId":10049,"journal":{"name":"Chiang Mai University journal of natural sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46414402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seasonal Occurrence of Caddisfly Larval Communities on a Coarse Substrate in the Upper Nan River, Northern Thailand 泰国北部南河上游粗质基质上球蝇幼虫群落的季节变化

Chiang Mai University journal of natural sciences Pub Date : 2022-07-11 DOI: 10.12982/cmujns.2022.047

P. Buntha, D. Thapanya

{"title":"Seasonal Occurrence of Caddisfly Larval Communities on a Coarse Substrate in the Upper Nan River, Northern Thailand","authors":"P. Buntha, D. Thapanya","doi":"10.12982/cmujns.2022.047","DOIUrl":"https://doi.org/10.12982/cmujns.2022.047","url":null,"abstract":"Abstract Caddisfly larvae are commonly found in the Nan River. Larvae were collected monthly from a cobble habitat for a period of two years to study the influence of seasonal changes on larval communities. A Surber sampler was placed in the cobble habitat in the riffle zone at four study sites along the upper Nan River. Field-collected larvae were identified at the family level in the laboratory. Physicochemical factors were measured in terms of water temperature, pH, turbidity, dissolved oxygen (DO) and biochemical oxygen demand (BOD5), as well as for concentrations of ammonia nitrogen (NH3-N), nitrate nitrogen (NO3-N) and orthophosphate (PO43-). Fifteen families of the caddisflies were found. The cool season was associated with the highest degree of density followed by the summer and rainy seasons. Hydropsychidae was the most common caddisfly present throughout the year. Hydroptilidae was common in the summer and cool seasons. Values of water temperature, pH, turbidity, DO, BOD5 and NO3-N among the three seasons were observed to be significantly different. According to the CCA analysis, water temperature, turbidity, BOD5, NO3-N and NH3-N factors had a positive relation to the density of Ecnomidae, Goeridae, Odontoceridae and Polycentropodidae. Remarkably, caddisfies in the families Hydropsychidae, Rhyacophilidae and Stenopsychidae were intolerant to variations in DO and pH values. The results of our study indicate that the physicochemical factors varied in conjunction with the different seasons, while communities and the degree of density of some caddisfly larvae were associated with variations of the physicochemical factors. Keywords: Trichoptera, Cobble, Environmental factors, Season","PeriodicalId":10049,"journal":{"name":"Chiang Mai University journal of natural sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43462316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Molecular Docking, and ADMET Study of N1-Hydrogen and N1-Benzoyl Pyrazoline as Antibacterial Agents N1氢和N1苯甲酰基吡唑啉抗菌剂的合成、分子对接及ADMET研究

Chiang Mai University journal of natural sciences Pub Date : 2022-07-11 DOI: 10.12982/cmujns.2022.048

Putra Tjitda, J. Jumina, T. Wahyuningsih

{"title":"Synthesis, Molecular Docking, and ADMET Study of N1-Hydrogen and N1-Benzoyl Pyrazoline as Antibacterial Agents","authors":"Putra Tjitda, J. Jumina, T. Wahyuningsih","doi":"10.12982/cmujns.2022.048","DOIUrl":"https://doi.org/10.12982/cmujns.2022.048","url":null,"abstract":"Abstract Syntheses of N1-hydrogen and N1-benzoyl pyrazoline derivatives and their antibacterial in vitro and in silico assays have been carried out. N1-Hydrogen pyrazoline derivatives were synthesized by cyclization of 2’-hydroxy chalcone, and the subsequent substitution reaction produced N1-benzoyl pyrazoline derivatives. The in vitro antibacterial assay was carried out by disc diffusion method. In silico evaluation was performed via molecular docking against ecKAS III enzyme (ID PDB: 1hnj) and ADMET prediction was carried out using pkCSM tool. The synthesis results showed that N1-hydrogen and N1-benzoyl pyrazoline derivatives were yielded in 50-83%. Antibacterial test results indicated that the presence of N1-benzoyl substituent decreased the antibacterial activity and was only active on Gram-positive bacteria. In comparison, the N1-hydrogen pyrazolines exhibited good antibacterial activity against both Gram-positive and negative bacteria. The ADMET result confirms that compound 2 has the potential to be evolved as a drug in the future. Keywords: Pyrazoline, Antibacterial, Molecular Docking, ADMET","PeriodicalId":10049,"journal":{"name":"Chiang Mai University journal of natural sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42926383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0