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WITHDRAWN: Proconvulsant effects of antidepressants: What is the current evidence? 撤回:抗抑郁药的抗惊厥作用:目前的证据是什么?
Epileptology Pub Date : 2014-09-02 DOI: 10.1016/J.EPILEP.2014.07.001
C. J. Landmark, O. Henning, S. Johannessen
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引用次数: 0
WITHDRAWN: The interictal dysphoric disorder of epilepsy: Evidence in favor 撤回:癫痫发作间期烦躁障碍:支持证据
Epileptology Pub Date : 2014-09-02 DOI: 10.1016/J.EPILEP.2014.07.003
M. Mula
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引用次数: 0
Peri-ictal behavioural change in people with an intellectual disability 智力残疾患者的围产期行为变化
Epileptology Pub Date : 2014-01-01 DOI: 10.1016/j.epilep.2014.07.002
Jessica York , Mike Kerr
{"title":"Peri-ictal behavioural change in people with an intellectual disability","authors":"Jessica York , Mike Kerr","doi":"10.1016/j.epilep.2014.07.002","DOIUrl":"https://doi.org/10.1016/j.epilep.2014.07.002","url":null,"abstract":"","PeriodicalId":100487,"journal":{"name":"Epileptology","volume":"2 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.epilep.2014.07.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71901780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Publisher׳s Note 出版社׳s注释
Epileptology Pub Date : 2014-01-01 DOI: 10.1016/j.epilep.2015.12.001
{"title":"Publisher׳s Note","authors":"","doi":"10.1016/j.epilep.2015.12.001","DOIUrl":"https://doi.org/10.1016/j.epilep.2015.12.001","url":null,"abstract":"","PeriodicalId":100487,"journal":{"name":"Epileptology","volume":"2 1","pages":"Page 6"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.epilep.2015.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71901781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How clinically useful are regulatory trials with new antiepileptic drugs? 新型抗癫痫药物的监管试验在临床上有多有用？
Epileptology Pub Date : 2013-03-01 DOI: 10.1016/j.epilep.2012.07.002
Martin J. Brodie
{"title":"How clinically useful are regulatory trials with new antiepileptic drugs?","authors":"Martin J. Brodie","doi":"10.1016/j.epilep.2012.07.002","DOIUrl":"https://doi.org/10.1016/j.epilep.2012.07.002","url":null,"abstract":"<div><p>Much time, money and effort on behalf of patients, doctors, statisticians, pharmaceutical personnel and regulators are spent in planning and undertaking clinical trial programmes that result in antiepileptic drugs reaching the marketplace and thereafter becoming available for treating people with epilepsy in everyday clinical practice. Rather unusually, both the American and European Authorities require separate trial programmes to licence each drug for their adjunctive and monotherapy use. These studies also often contribute to clinical guideline development. This short paper discusses the design of these trials and their clinical value to the clinician.</p></div>","PeriodicalId":100487,"journal":{"name":"Epileptology","volume":"1 1","pages":"Pages 21-24"},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.epilep.2012.07.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71899828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Treatment guidelines: Women of fertile age 治疗指南：育龄妇女
Epileptology Pub Date : 2013-03-01 DOI: 10.1016/j.epilep.2012.11.003
Anne Sabers
{"title":"Treatment guidelines: Women of fertile age","authors":"Anne Sabers","doi":"10.1016/j.epilep.2012.11.003","DOIUrl":"https://doi.org/10.1016/j.epilep.2012.11.003","url":null,"abstract":"<div><p>In women, from puberty, during pregnancy and to menopause, epilepsy presents several unique challenges to physicians and other health-care providers. Women with epilepsy have increased risks of sexual dysfunction, menstrual disturbances, premature menopause, and infertility; and seizure activity and severity can be influenced by the cyclic variations of sex hormones. Oral contraceptive efficacy can be affected by antiepileptic drugs and vice versa. Furthermore, the offspring of women receiving antiepileptic drugs are at increased risk for congenital malformations, and this risk is associated with specific drug regimens. Physicians have to understand and respond to these specific issues to ensure sufficient therapeutic decisions throughout the reproductive stages.</p></div>","PeriodicalId":100487,"journal":{"name":"Epileptology","volume":"1 1","pages":"Pages 11-16"},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.epilep.2012.11.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71899824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Management issues for patients with idiopathic generalized epilepsies 特发性全身性癫痫患者的管理问题
Epileptology Pub Date : 2013-03-01 DOI: 10.1016/j.epilep.2012.11.001
Elza Márcia Targas Yacubian, Gerardo Maria de Araújo Filho
{"title":"Management issues for patients with idiopathic generalized epilepsies","authors":"Elza Márcia Targas Yacubian,&nbsp;Gerardo Maria de Araújo Filho","doi":"10.1016/j.epilep.2012.11.001","DOIUrl":"https://doi.org/10.1016/j.epilep.2012.11.001","url":null,"abstract":"<div><p>Idiopathic generalized epilepsies (IGEs) are eight epilepsies defined in the 1989 ILAE Classification usually starting in childhood or adolescence. Since IGEs treatment is dependent on syndromic characterization, the clinical features are still the cornerstone of accurate classification and selection of appropriate treatment. We reviewed evidence-based data on treatment with antiepileptic drugs, as well as prognostic factors in IGEs. Evidence-based data support the use of valproate and ethosuximide in monotherapy for treatment of childhood absence epilepsy; topiramate in monotherapy for primarily generalized tonic–clonic seizures (PGTCS); and, as adjunctive therapy, of lamotrigine, levetiracetam and topiramate for PGTCS and levetiracetam for myoclonic seizures.</p></div>","PeriodicalId":100487,"journal":{"name":"Epileptology","volume":"1 1","pages":"Pages 1-10"},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.epilep.2012.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71899826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
When and how to stop antiepileptic drugs 何时以及如何停用抗癫痫药物
Epileptology Pub Date : 2013-03-01 DOI: 10.1016/J.EPILEP.2012.07.001
E. Beghi, D. Schmidt
{"title":"When and how to stop antiepileptic drugs","authors":"E. Beghi, D. Schmidt","doi":"10.1016/J.EPILEP.2012.07.001","DOIUrl":"https://doi.org/10.1016/J.EPILEP.2012.07.001","url":null,"abstract":"","PeriodicalId":100487,"journal":{"name":"Epileptology","volume":"17 1","pages":"17-20"},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88767971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Treatment of first seizure in adults: A comprehensive approach integrating 10 key principles 成人首次癫痫发作的治疗：综合10项关键原则的综合方法
Epileptology Pub Date : 2013-03-01 DOI: 10.1016/j.epilep.2013.01.005
Bernd Pohlmann-Eden, Karen T. Legg
{"title":"Treatment of first seizure in adults: A comprehensive approach integrating 10 key principles","authors":"Bernd Pohlmann-Eden,&nbsp;Karen T. Legg","doi":"10.1016/j.epilep.2013.01.005","DOIUrl":"https://doi.org/10.1016/j.epilep.2013.01.005","url":null,"abstract":"<div><p>Assessment of a first seizure (FS) presentation requires a comprehensive and systematic approach to address the complexity of this condition and all of the open questions with regards to accurate interpretation of the initial event, necessary diagnostic steps, prognosis and need for antiepileptic drugs (AED). Counseling about key life style issues and safety considerations in daily life are a major component in the first meeting; which should allow enough time to help to create trust in this vulnerable situation. “Treatment” in this review is therefore used in a holistic way and is not restricted to medication only. Pharmacological treatment of a FS aims to restore normal neuronal function and helps to suppress further seizures. Choosing pharmacological intervention must be guided by incorporating all available clinical information, structural–functional relationships, the underlying pathology, which may specifically include a treatable systematic disease, and the individual's requirements and inclination. Pharmacological treatment should always be considered if the index seizure is not the “first seizure” but actually reflects newly diagnosed epilepsy. AED treatment after a FS is also reasonable, if additional functional and structural tests suggest an epileptic process or if comorbid medical conditions exist (e.g. polytrauma, anticoagulation in an elderly patient with prior stroke) in which any further seizure would lead to additional harm. A comprehensive systematic approach incorporating 10 key principles is presented.</p></div>","PeriodicalId":100487,"journal":{"name":"Epileptology","volume":"1 1","pages":"Pages 61-67"},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.epilep.2013.01.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71899834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Assessment of adverse effects of antiepileptic drugs: The patient's view 抗癫痫药物不良反应的评估:患者的观点
Epileptology Pub Date : 2013-03-01 DOI: 10.1016/J.EPILEP.2013.01.003
T. May
{"title":"Assessment of adverse effects of antiepileptic drugs: The patient's view","authors":"T. May","doi":"10.1016/J.EPILEP.2013.01.003","DOIUrl":"https://doi.org/10.1016/J.EPILEP.2013.01.003","url":null,"abstract":"","PeriodicalId":100487,"journal":{"name":"Epileptology","volume":"5 1","pages":"46-54"},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86471339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
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