Deep Brain Stimulation最新文献

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Deep Brain Stimulation for Essential Tremor 脑深部电刺激治疗特发性震颤
Deep Brain Stimulation Pub Date : 2020-06-01 DOI: 10.1093/med/9780190647209.003.0003
B. Bluett
{"title":"Deep Brain Stimulation for Essential Tremor","authors":"B. Bluett","doi":"10.1093/med/9780190647209.003.0003","DOIUrl":"https://doi.org/10.1093/med/9780190647209.003.0003","url":null,"abstract":"Essential tremor (ET) is one of the most common movement disorders and can result in disabling symptoms that are refractory to standard medications. In 1997, the US Food and Drug Administration approved deep brain stimulation (DBS) of the ventral intermedius nucleus of the thalamus for treatment of ET. DBS often reduces or eliminates the need for medications to treat ET. Proper patient selection and expertise in DBS programming are critical to ensure optimal outcomes. Recent advances in DBS include directional current steering and multisource independent constant current to program each electrode with its own power source. This chapter discusses proper patient selection, programming guidelines, and clinical pearls in DBS for ET.","PeriodicalId":100359,"journal":{"name":"Deep Brain Stimulation","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90437363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Stimulation-Induced Dyskinesia, Interleaving Settings, and Management of Subthalamic Nucleus Deep Brain Stimulation in DYT1 Dystonia DYT1肌张力障碍中刺激诱导的运动障碍,交错设置和丘脑下核深部脑刺激的管理
Deep Brain Stimulation Pub Date : 2020-06-01 DOI: 10.1093/med/9780190647209.003.0038
Kyle T. Mitchell, Kristen Dodenhoff, P. Starr, J. Ostrem
{"title":"Stimulation-Induced Dyskinesia, Interleaving Settings, and Management of Subthalamic Nucleus Deep Brain Stimulation in DYT1 Dystonia","authors":"Kyle T. Mitchell, Kristen Dodenhoff, P. Starr, J. Ostrem","doi":"10.1093/med/9780190647209.003.0038","DOIUrl":"https://doi.org/10.1093/med/9780190647209.003.0038","url":null,"abstract":"DYT1 dystonia is a primary dystonia with potential for significant symptomatic improvement after bilateral deep brain stimulation (DBS) of the globus pallidus interna (GPi). GPi is the historical target of choice for this disease. This chapter presents a case of an adolescent with disabling generalized DYT1 dystonia who underwent bilateral subthalamic nucleus (STN) DBS as part of a prospective clinical trial. While limb and cervical dystonia dramatically improved with DBS, programming was limited by stimulation-induced bilateral limb dyskinesia, including in the left arm, which was previously unaffected by dystonia. After years of evolving symptoms and complex programming, bilateral interleaved settings using both a contact in motor STN and the most dorsal DBS contact in the zona incerta resulted in sustained, near-complete resolution of dystonia without side effects. This case illustrates the use of the STN as an effective DBS target for primary dystonia, although complex programming was necessary to mitigate stimulation-induced dyskinesia.","PeriodicalId":100359,"journal":{"name":"Deep Brain Stimulation","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76904830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Rescue Ventral Intermediate Thalamus Deep Brain Stimulation to Address Refractory Tremor Following Subthalamic Nucleus Deep Brain Stimulation With Brittle Dyskinesia 救援腹侧中间丘脑深部脑刺激治疗丘脑下核深部脑刺激后伴脆性运动障碍的难治性震颤
Deep Brain Stimulation Pub Date : 2020-06-01 DOI: 10.1093/med/9780190647209.003.0023
Mitra Afshari, J. Ostrem, M. S. Luciano, P. Larson
{"title":"Rescue Ventral Intermediate Thalamus Deep Brain Stimulation to Address Refractory Tremor Following Subthalamic Nucleus Deep Brain Stimulation With Brittle Dyskinesia","authors":"Mitra Afshari, J. Ostrem, M. S. Luciano, P. Larson","doi":"10.1093/med/9780190647209.003.0023","DOIUrl":"https://doi.org/10.1093/med/9780190647209.003.0023","url":null,"abstract":"This chapter discusses a case in which a “rescue” deep brain stimulation (DBS) lead was implanted to address suboptimal tremor control. The patient was a 52-year-old woman with disabling bilateral postural and action hand tremor who also had mild parkinsonian signs. An essential tremor (ET)–Parkinson disease (PD) syndrome was suspected, and subthalamic nucleus (STN) DBS was pursued. Attempts at optimizing tremor control by reprogramming were limited by the induction of brittle dyskinesia even with small amounts of stimulation. Bilateral ventral intermediate thalamus DBS leads were then implanted, and the tremors improved significantly. Troubleshooting strategies for optimizing tremor control and reducing STN DBS–induced brittle dyskinesia are discussed. The chapter reviews important learning points on DBS target selection for ET, PD, and ET-PD spectrum syndromes.","PeriodicalId":100359,"journal":{"name":"Deep Brain Stimulation","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81577051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tardive Dystonia and Dyskinesia Responsive to Deep Brain Stimulation 迟发性肌张力障碍和运动障碍对深部脑刺激的反应
Deep Brain Stimulation Pub Date : 2020-06-01 DOI: 10.1093/med/9780190647209.003.0044
Shannon Y. Chiu, I. Malaty
{"title":"Tardive Dystonia and Dyskinesia Responsive to Deep Brain Stimulation","authors":"Shannon Y. Chiu, I. Malaty","doi":"10.1093/med/9780190647209.003.0044","DOIUrl":"https://doi.org/10.1093/med/9780190647209.003.0044","url":null,"abstract":"Tardive disorders encompass phenomenologically diverse delayed-onset persistent involuntary motor symptoms associated with exposure to dopamine receptor blocking agents. Two common tardive disorders encountered in the clinical setting include tardive dyskinesia and tardive dystonia. This chapter presents a patient with severe refractory tardive dyskinesia and also tardive dystonia, manifesting as frequent and disabling retropulsion. He initially underwent bilateral globus pallidus interna (GPi) deep brain stimulation (DBS) but was found to have lead migration secondary to his severe hyperkinetic movements. He had persistent symptoms despite lead revision and ultimately required bilateral subthalamic nucleus (STN) rescue DBS implantation. The rescue procedure was synergistic with the initial GPi DBS and markedly improved his symptoms. Severe tardive dyskinesia and dystonia may respond to bilateral GPi DBS, and if necessary, rescue STN DBS can be added.","PeriodicalId":100359,"journal":{"name":"Deep Brain Stimulation","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84758070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Choosing a Target for Deep Brain Stimulation in Dystonia-Associated Tremor 肌张力障碍相关震颤的深部脑刺激靶点选择
Deep Brain Stimulation Pub Date : 2020-06-01 DOI: 10.1093/med/9780190647209.003.0037
M. Siddiqui, S. Tatter
{"title":"Choosing a Target for Deep Brain Stimulation in Dystonia-Associated Tremor","authors":"M. Siddiqui, S. Tatter","doi":"10.1093/med/9780190647209.003.0037","DOIUrl":"https://doi.org/10.1093/med/9780190647209.003.0037","url":null,"abstract":"This chapter presents a case of medication-refractory primary generalized dystonia presenting with disabling symptoms of cervical dystonia and dystonic bilateral arm tremors. This case posed a challenge in the choice of the appropriate target for deep brain stimulation (DBS) because the targeting of the globus pallidus interna improves dystonia symptoms but may have a less predictable response to tremor. DBS targeting the ventral intermedius may not in many cases improve dystonia symptoms but can effectively control tremor. The authors describe a case in which they employed a systematic approach including implanting multiple leads in different DBS targets. This approach resulted in a favorable outcome for this patient in dystonia and in dystonic tremor.","PeriodicalId":100359,"journal":{"name":"Deep Brain Stimulation","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83225959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Mutations and Deep Brain Stimulation 基因突变和深部脑刺激
Deep Brain Stimulation Pub Date : 2020-06-01 DOI: 10.1093/med/9780190647209.003.0011
J. T. Hinkle, A. Butala, V. Parfenov, Kelly A. Mills, Z. Mari
{"title":"Genetic Mutations and Deep Brain Stimulation","authors":"J. T. Hinkle, A. Butala, V. Parfenov, Kelly A. Mills, Z. Mari","doi":"10.1093/med/9780190647209.003.0011","DOIUrl":"https://doi.org/10.1093/med/9780190647209.003.0011","url":null,"abstract":"Parkinson disease (PD) is a neurodegenerative disorder characterized by rest tremor, rigidity, bradykinesia, and postural instability. While most cases of PD are sporadic in nature, cases secondary to genetic mutations have been identified. These are typically monogenic and often present as early-onset or juvenile-onset PD. While rare, individuals with PD may harbor multiple pathogenic variants in PD-linked genes, potentially leading to more severe presentations. This chapter reviews available data regarding deep brain stimulation (DBS) targets and DBS outcomes in cases that are genetically proved to be PD. We report a patient with juvenile-onset PD whose course featured severe peak-dose dyskinesias and generalized off dystonias. Genetic testing supported a rare diagnosis of digenic PD, with homogenous deletions in PRKN (Parkin) and a single transition in PARK6 (PINK1). Bilateral DBS electrodes were implanted into the globus pallidus pars interna (GPi), leading to significant amelioration of both off and on symptoms.","PeriodicalId":100359,"journal":{"name":"Deep Brain Stimulation","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77846791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep Brain Stimulation Targeting the Ventral Intermediate Nucleus of the Thalamus for Parkinsonian Tremor and Later Adding the Globus Pallidus Interna for Parkinson Disease Features 针对丘脑腹侧中间核的深部脑刺激治疗帕金森性震颤,随后加入内苍白球治疗帕金森病特征
Deep Brain Stimulation Pub Date : 2020-06-01 DOI: 10.1093/med/9780190647209.003.0033
Qiang Zhang, T. Thomsen
{"title":"Deep Brain Stimulation Targeting the Ventral Intermediate Nucleus of the Thalamus for Parkinsonian Tremor and Later Adding the Globus Pallidus Interna for Parkinson Disease Features","authors":"Qiang Zhang, T. Thomsen","doi":"10.1093/med/9780190647209.003.0033","DOIUrl":"https://doi.org/10.1093/med/9780190647209.003.0033","url":null,"abstract":"Deep brain stimulation (DBS) targeting the ventral intermediate (Vim) nucleus of thalamus has been established as an effective therapy for patients with debilitating essential tremor. However, some patients initially diagnosed with essential tremor (ET) later develop idiopathic Parkinson disease (PD), and Vim DBS is not as effective for other PD-related symptoms, including bradykinesia, rigidity, and dyskinesia. This chapter describes a patient with PD who initially presented with debilitating right-dominant tremor that was misdiagnosed as ET. He received bilateral Vim DBS with good tremor control. Two years later, he received bilateral globus pallidus internus (GPi) DBS for progression of his PD, and he has been reporting adequate relief of his PD symptoms. For patients with debilitating tremor, but relatively mild or no parkinsonian symptoms on presentation, after medical trials have been administered, a Vim DBS is a reasonable option for tremor relief. A second DBS placement targeting the GPi or subthalamic nucleus (STN) may be considered if more parkinsonian symptoms evolve and progress.","PeriodicalId":100359,"journal":{"name":"Deep Brain Stimulation","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83682658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral Globus Pallidus Deep Brain Stimulation for Dystonia and Dystonic Tremor in Spinocerebellar Ataxia 17 双侧苍白球深部脑刺激治疗脊髓小脑共济失调患者肌张力障碍和肌张力障碍震颤17
Deep Brain Stimulation Pub Date : 2020-06-01 DOI: 10.1093/med/9780190647209.003.0042
A. Shukla, Pamela Zeilman
{"title":"Bilateral Globus Pallidus Deep Brain Stimulation for Dystonia and Dystonic Tremor in Spinocerebellar Ataxia 17","authors":"A. Shukla, Pamela Zeilman","doi":"10.1093/med/9780190647209.003.0042","DOIUrl":"https://doi.org/10.1093/med/9780190647209.003.0042","url":null,"abstract":"Spinocerebellar ataxia 17 (SCA17) is a rare form of autosomal dominant cerebellar ataxia. SCA17 results from trinucleotide repeat expansions and has no effective symptomatic treatments to date. This chapter describes a case of SCA17 with dystonic symptoms that presented during adolescence. Symptoms were generalized in distribution and were accompanied with a dystonic tremor of the arms. Because many medication trials did not alleviate the patient’s symptoms, he underwent bilateral globus pallidus interna (GPi) deep brain stimulation (DBS) surgery. Several DBS programming sessions were performed. Dystonia and dystonic tremor were controlled with the settings adjusted at high pulse widths and low frequencies. Furthermore, the cyclic mode of stimulation was employed to mitigate the capsular side effects. Two years after DBS surgery, the patient presented with cerebellar ataxia that prompted an extensive workup, including genetic testing and revision of his diagnosis from generalized dystonia to a dystonia syndrome. The patient continues to endorse symptomatic benefits with DBS for dystonia and dystonic tremor 11 years after surgery, despite a diagnosis of dystonia syndrome. The current case of SCA17 cerebellar ataxia indicates that bilateral GPi DBS is a potential option for the long-term symptomatic treatment of dystonia and tremor symptoms manifesting as a part of a clinical syndrome.","PeriodicalId":100359,"journal":{"name":"Deep Brain Stimulation","volume":"169 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80629640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient Selection Criteria for Deep Brain Stimulation for Parkinson Disease 帕金森病深部脑刺激的患者选择标准
Deep Brain Stimulation Pub Date : 2020-06-01 DOI: 10.1093/med/9780190647209.003.0008
Laura S. Surillo Dahdah, P. O'Suilleabhain, Hrishikesh Dadhich, Mazen T Elkurd, Shilpa Chitnis, R. Dewey
{"title":"Patient Selection Criteria for Deep Brain Stimulation for Parkinson Disease","authors":"Laura S. Surillo Dahdah, P. O'Suilleabhain, Hrishikesh Dadhich, Mazen T Elkurd, Shilpa Chitnis, R. Dewey","doi":"10.1093/med/9780190647209.003.0008","DOIUrl":"https://doi.org/10.1093/med/9780190647209.003.0008","url":null,"abstract":"Patient selection is critical for optimizing clinical outcomes after deep brain stimulation (DBS) surgery. Patient expectations need to be addressed before DBS surgery to avoid disappointment. There are generally accepted criteria for DBS candidacy for treatment of Parkinson disease (PD), essential tremor (ET), and dystonia. For PD, selection criteria include a diagnosis of idiopathic PD and the presence of disabling or troubling motor symptoms such as motor fluctuations or dyskinesia (despite optimized pharmacologic treatment). Medication-resistant tremor is also an indication. The response of problematic motor symptoms to dopaminergic drugs is an important predictor of DBS response, favoring selection of patients for whom levodopa substantially improves tremor, bradykinesia, and rigidity. Rarely, gait is improved with DBS, and in some cases freezing can improve, although this is not a predictable post-DBS feature. Exclusion criteria include serious medical comorbidities, uncontrolled psychiatric illness (thought and mood disorders), and dementia. Preoperative magnetic resonance imaging with extensive white matter changes, vascular malformations, severe cerebral atrophy, or hydrocephalus can also be exclusions. The patient should clearly understand the risks and benefits of DBS, which should be assessed using a preoperative multidisciplinary evaluation (neurology, neurosurgery, neuropsychology, psychiatry, and rehabilitation). Use of a social worker and/or nutritionist can also be helpful in select cases.","PeriodicalId":100359,"journal":{"name":"Deep Brain Stimulation","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81459196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cerebral Venous Infarction After Deep Brain Stimulation Surgery 脑深部刺激手术后脑静脉梗死
Deep Brain Stimulation Pub Date : 2020-06-01 DOI: 10.1093/med/9780190647209.003.0029
Andi N. Sendjaja, T. Morishita, Tooru Inoue
{"title":"Cerebral Venous Infarction After Deep Brain Stimulation Surgery","authors":"Andi N. Sendjaja, T. Morishita, Tooru Inoue","doi":"10.1093/med/9780190647209.003.0029","DOIUrl":"https://doi.org/10.1093/med/9780190647209.003.0029","url":null,"abstract":"Venous infarction is an important adverse event potentially encountered in the practice of deep brain stimulation (DBS). This adverse event is considered to result from damage to the cortical vein during surgery and is noted on postoperative day 1 or 2 owing to neurologic symptoms such as confusion and headache. The imaging findings are characterized by edema surrounding the trajectory of the DBS lead and flame-shaped hemorrhage in some cases. Venous infarction can be managed conservatively with careful observation, and the prognosis is usually benign. The neurologic condition of patients can in many cases return to baseline after days to weeks, as observed in this case. The prognostic information is valuable for reassuring afflicted patients and their families.","PeriodicalId":100359,"journal":{"name":"Deep Brain Stimulation","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88601334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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