Chinese Journal of Cancer Pub Date : 2014-05-01 Epub Date: 2013-10-09 DOI: 10.5732/cjc.013.10122

Rishil J Kathawala, Yi-Jun Wang, Charles R Ashby, Zhe-Sheng Chen

引用次数: 44

Cancer risk among patients with hereditary muscular dystrophies: a population-based study in Taiwan, 1997-2009. 遗传性肌营养不良患者的癌症风险:台湾1997-2009年一项基于人群的研究。

Chinese Journal of Cancer Pub Date : 2014-05-01 Epub Date: 2014-01-02 DOI: 10.5732/cjc.013.10156

Gen-Min Lin, Yi-Hwei Li

{"title":"Cancer risk among patients with hereditary muscular dystrophies: a population-based study in Taiwan, 1997-2009.","authors":"Gen-Min Lin, Yi-Hwei Li","doi":"10.5732/cjc.013.10156","DOIUrl":"https://doi.org/10.5732/cjc.013.10156","url":null,"abstract":"Muscular dystrophies (MD) comprise a heterogeneous group of hereditary myopathic diseases. In this group, myotonic MD is associated with an increased cancer risk. However, the cancer risk in other types of MD is unclear. To address this gap in knowledge, we assessed data obtained from the Taiwan Health Insurance Program database. A total of 1,272 patients with MD diagnosed between 1997 and 2009 were enrolled. They were followed up for cancer during the same period by record linkage with the cancer certification in Taiwan. Age- and sex-standardized incidence ratios (SIRs) of overall and site-specific cancers were calculated. For congenital and progressive hereditary MD, there were 685 and 505 cases (males: 69.5% and 80.6%), the median ages at diagnosis were 16 and 13 years, and the mean follow-up durations were 7.12 and 5.06 years, respectively. In addition, cancers were developed in 10 patients with congenital MD and 3 patients with progressive hereditary MD. Female MD patients exhibited an increased cancer risk, yielding an SIR of 3.37 [95% confidence interval (CI) = 1.38-8.25] in congenital MD and 2.95 (95% CI = 0.95-9.19) in hereditary progressive MD. Site-specific cancer SIRs were not powered to be significantly different. In conclusion, genetic defects in hereditary MD may increase cancer risks in females and a sex difference should be further investigated. ","PeriodicalId":10034,"journal":{"name":"Chinese Journal of Cancer","volume":"33 5","pages":"256-8"},"PeriodicalIF":0.0,"publicationDate":"2014-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/76/5f/cjc-33-05-256.PMC4026546.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32025148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The role of EPH receptors in cancer-related epithelial-mesenchymal transition. EPH受体在癌症相关上皮-间质转化中的作用。

Chinese Journal of Cancer Pub Date : 2014-05-01 Epub Date: 2013-10-09 DOI: 10.5732/cjc.013.10108

Rui-Xin Li, Zi-Hua Chen, Zhi-Kang Chen

引用次数: 22

A nomogram to predict Gleason sum upgrading of clinically diagnosed localized prostate cancer among Chinese patients. 预测中国临床诊断的局限性前列腺癌患者Gleason sum升级的nomogram。

Chinese Journal of Cancer Pub Date : 2014-05-01 Epub Date: 2014-02-14 DOI: 10.5732/cjc.013.10137

Jin-You Wang, Yao Zhu, Chao-Fu Wang, Shi-Lin Zhang, Bo Dai, Ding-Wei Ye

{"title":"A nomogram to predict Gleason sum upgrading of clinically diagnosed localized prostate cancer among Chinese patients.","authors":"Jin-You Wang, Yao Zhu, Chao-Fu Wang, Shi-Lin Zhang, Bo Dai, Ding-Wei Ye","doi":"10.5732/cjc.013.10137","DOIUrl":"https://doi.org/10.5732/cjc.013.10137","url":null,"abstract":"Although several models have been developed to predict the probability of Gleason sum upgrading between biopsy and radical prostatectomy specimens, most of these models are restricted to prostate-specific antigen screening-detected prostate cancer. This study aimed to build a nomogram for the prediction of Gleason sum upgrading in clinically diagnosed prostate cancer. The study cohort comprised 269 Chinese prostate cancer patients who underwent prostate biopsy with a minimum of 10 cores and were subsequently treated with radical prostatectomy. Of all included patients, 220 (81.8%) were referred with clinical symptoms. The prostate-specific antigen level, primary and secondary biopsy Gleason scores, and clinical T category were used in a multivariate logistic regression model to predict the probability of Gleason sum upgrading. The developed nomogram was validated internally. Gleason sum upgrading was observed in 90 (33.5%) patients. Our nomogram showed a bootstrap-corrected concordance index of 0.789 and good calibration using 4 readily available variables. The nomogram also demonstrated satisfactory statistical performance for predicting significant upgrading. External validation of the nomogram published by Chun et al. in our cohort showed a marked discordance between the observed and predicted probabilities of Gleason sum upgrading. In summary, a new nomogram to predict Gleason sum upgrading in clinically diagnosed prostate cancer was developed, and it demonstrated good statistical performance upon internal validation. ","PeriodicalId":10034,"journal":{"name":"Chinese Journal of Cancer","volume":"33 5","pages":"241-8"},"PeriodicalIF":0.0,"publicationDate":"2014-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/03/cjc-33-05-241.PMC4026544.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32147065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

A prospective analysis of factors that influence weight loss in patients undergoing radiotherapy. 影响放疗患者体重减轻因素的前瞻性分析。

Chinese Journal of Cancer Pub Date : 2014-04-01 Epub Date: 2013-10-09 DOI: 10.5732/cjc.013.10009

Jon Cacicedo, Francisco Casquero, Lorea Martinez-Indart, Olga del Hoyo, Alfonso Gomez de Iturriaga, Arturo Navarro, Pedro Bilbao

{"title":"A prospective analysis of factors that influence weight loss in patients undergoing radiotherapy.","authors":"Jon Cacicedo, Francisco Casquero, Lorea Martinez-Indart, Olga del Hoyo, Alfonso Gomez de Iturriaga, Arturo Navarro, Pedro Bilbao","doi":"10.5732/cjc.013.10009","DOIUrl":"https://doi.org/10.5732/cjc.013.10009","url":null,"abstract":"Malnutrition occurs frequently in patients with cancer. Indeed, a variety of nutritional and tumor-related factors must be taken into account in these patients. Recognizing this relationship, we aimed to prospectively evaluate the risk factors that influence weight loss in patients undergoing radiotherapy with oral nutritional supplementation and dietetic counseling. Weight loss of 74 patients during radiotherapy and 1 month after treatment was analyzed. Parameters such as age, gender, tumor location, tumor stage, Eastern Cooperative Oncology Group performance status (ECOG PS) score, and the use of chemotherapy were analyzed to evaluate their influence on weight loss. All patients underwent oral nutritional supplementation and dietetic counseling. Forty-six (65.7%) patients lost weight, with a mean weight loss of (4.73 ± 3.91) kg, during radiotherapy. At 1 month after treatment, 45 (66.2%) patients lost weight, presenting a mean weight loss of (4.96 ± 4.04) kg, corresponding to a (6.84 ± 5.24)% net reduction from their baseline weight. Head and neck cancer patients had a mean weight loss of (3.25 ± 5.30) kg, whereas the remaining patients had a mean weight loss of (0.64 ± 2.39) kg (P = 0.028) during radiotherapy. In the multivariate analysis, the head and neck tumor location (P = 0.005), use of chemotherapy (P = 0.011), and ECOG PS score of 2-3 (P = 0.026) were considered independent risk factors. Nutritional status and parameters, such as tumor location (especially the head and neck), the use of chemotherapy, and the ECOG PS score, should be evaluated before radiotherapy because these factors can influence weight loss during radiotherapy and 1 month after treatment. ","PeriodicalId":10034,"journal":{"name":"Chinese Journal of Cancer","volume":"33 4","pages":"204-10"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5732/cjc.013.10009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31790172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Air pollution: a smoking gun for cancer. 空气污染:癌症的确凿证据。

Chinese Journal of Cancer Pub Date : 2014-04-01 Epub Date: 2014-03-18 DOI: 10.5732/cjc.014.10034

Wei Zhang, Chao-Nan Qian, Yi-Xin Zeng

引用次数: 30

Impact of fine particles in ambient air on lung cancer. 环境空气中细颗粒物对肺癌的影响。

Chinese Journal of Cancer Pub Date : 2014-04-01 Epub Date: 2014-03-17 DOI: 10.5732/cjc.014.10039

Gerard Hoek, Ole Raaschou-Nielsen

引用次数: 35

The International Agency for Research on Cancer (IARC) evaluation of the carcinogenicity of outdoor air pollution: focus on China. 国际癌症研究机构（IARC）对室外空气污染致癌性的评估：聚焦中国。

Chinese Journal of Cancer Pub Date : 2014-04-01 DOI: 10.5732/cjc.014.10028

Dana Loomis, Wei Huang, Guosheng Chen

{"title":"The International Agency for Research on Cancer (IARC) evaluation of the carcinogenicity of outdoor air pollution: focus on China.","authors":"Dana Loomis, Wei Huang, Guosheng Chen","doi":"10.5732/cjc.014.10028","DOIUrl":"10.5732/cjc.014.10028","url":null,"abstract":"The International Agency for Research on Cancer (IARC) has classified outdoor air pollution and the particulate matter (PM) in outdoor air pollution as carcinogenic to humans, as based on sufficient evidence of carcinogenicity in humans and experimental animals and strong support by mechanistic studies. The data with important contributions to the evaluation are reviewed, highlighting the data with particular relevance to China, and implications of the evaluation with respect to China are discussed. The air pollution levels in Chinese cities are among the highest observed in the world today and frequently exceed health-based national and international guidelines. Data from high-quality epidemiologic studies in Asia, Europe, and North America consistently show positive associations between lung cancer and PM exposure and other indicators of air pollution, which persist after adjustment for important lung cancer risk factors, such as tobacco smoking. Epidemiologic data from China are limited but nevertheless indicate an increased risk of lung cancer associated with several air pollutants. Excess cancer risk is also observed in experimental animals exposed to polluted outdoor air or extracted PM. The exposure of several species to outdoor air pollution is associated with markers of genetic damage that have been linked to increased cancer risk in humans. Numerous studies from China, especially genetic biomarker studies in exposed populations, support that the polluted air in China is genotoxic and carcinogenic to humans. The evaluation by IARC indicates both the need for further research into the cancer risks associated with exposure to air pollution in China and the urgent need to act to reduce exposure to the population. ","PeriodicalId":10034,"journal":{"name":"Chinese Journal of Cancer","volume":"33 4","pages":"189-96"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f1/1f/cjc-33-04-189.PMC3975184.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32231676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colorectal cancer: new developments after the 2013 ECCO/ESMO congress. 结直肠癌：2013 年 ECCO/ESMO 大会后的新进展。

Chinese Journal of Cancer Pub Date : 2014-04-01 Epub Date: 2014-02-25 DOI: 10.5732/cjc.013.10203

Nawfel Mellas, Zineb Benbrahim, Omar El Mesbahi

引用次数: 0

A bird's eye view of the air pollution-cancer link in China. 鸟瞰中国空气污染与癌症的关系。

Chinese Journal of Cancer Pub Date : 2014-04-01 Epub Date: 2014-03-18 DOI: 10.5732/cjc.014.10030

Yu-Bei Huang, Feng-Ju Song, Qun Liu, Wei-Qin Li, Wei Zhang, Ke-Xin Chen

{"title":"A bird's eye view of the air pollution-cancer link in China.","authors":"Yu-Bei Huang, Feng-Ju Song, Qun Liu, Wei-Qin Li, Wei Zhang, Ke-Xin Chen","doi":"10.5732/cjc.014.10030","DOIUrl":"https://doi.org/10.5732/cjc.014.10030","url":null,"abstract":"Air pollution in China comes from multiple sources, including coal consumption, construction and industrial dust, and vehicle exhaust. Coal consumption in particular directly determines the emissions of three major air pollutants: dust, sulfur dioxide (SO(2)), and nitrogen oxide (NOx). The rapidly increasing number of civilian vehicles is expected to bring NOx emission to a very high level. Contrary to expectations, however, existing data show that the concentrations of major pollutants [particulate matter-10 (PM10), SO(2), and nitrogen dioxide (NO(2))] in several large Chinese cities have declined during the past decades, though they still exceed the national standards of ambient air quality. Archived data from China does not fully support that the concentrations of pollutants directly depend on local emissions, but this is likely due to inaccurate measurement of pollutants. Analyses on the cancer registry data show that cancer burden related to air pollution is on the rise in China and will likely increase further, but there is a lack of data to accurately predict the cancer burden. Past experience from other countries has sounded alarm of the link between air pollution and cancer. The quantitative association requires dedicated research as well as establishment of needed monitoring infrastructures and cancer registries. The air pollution-cancer link is a serious public health issue that needs urgent investigation.","PeriodicalId":10034,"journal":{"name":"Chinese Journal of Cancer","volume":"33 4","pages":"176-88"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/86/a3/cjc-33-04-176.PMC3975183.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32181893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

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