Clinical Leukemia最新文献_第10页

Infant with Granulocytic Sarcoma of the Ovary: An Unusual Case Presentation of Acute Myelogenous Leukemia (M6) 婴儿伴卵巢粒细胞性肉瘤:急性髓性白血病的罕见表现(M6)

Clinical Leukemia Pub Date : 2007-06-01 DOI: 10.3816/CLK.2007.n.016

Mukta Kumar , Masayo Watanabe , Vivekanand Singh , Linda D. Cooley

引用次数: 2

Selected Clinical Trials in Leukemia and MDS 白血病和MDS的选定临床试验

Clinical Leukemia Pub Date : 2007-06-01 DOI: 10.1016/S1931-6925(13)60069-8

引用次数: 0

Do Kinase Domain Mutations in Philadelphia Chromosome–Positive Leukemias Really Matter? 费城染色体阳性白血病的激酶结构域突变真的重要吗?

Clinical Leukemia Pub Date : 2007-06-01 DOI: 10.3816/CLK.2007.n.010

Tariq I. Mughal MD (Associate Editor)

引用次数: 1

The Use of Dasatinib in Chronic Myeloid Leukemia: Some Practical Considerations 达沙替尼在慢性髓系白血病中的应用:一些实际考虑

Clinical Leukemia Pub Date : 2007-06-01 DOI: 10.3816/CLK.2007.n.013

David Marin , Dragana Milojkovic , Marco Bua , Hugues de Lavallade , Catharina Andreasson , Priscilla R. Sauramba , Julia Nicol , Nuria Gonzalez-Cinca , John M. Goldman , Jane F. Apperley

引用次数: 8

Update on Genomic Profiling in Chronic Lymphocytic Leukemia 慢性淋巴细胞白血病基因组谱研究进展

Clinical Leukemia Pub Date : 2007-06-01 DOI: 10.3816/CLK.2007.n.011

Stephan Stilgenbauer

{"title":"Update on Genomic Profiling in Chronic Lymphocytic Leukemia","authors":"Stephan Stilgenbauer","doi":"10.3816/CLK.2007.n.011","DOIUrl":"10.3816/CLK.2007.n.011","url":null,"abstract":"<div><p>The clinical staging systems developed by Rai and Binet have remained the mainstay for clinical decision-making in patients with chronic lymphocytic leukemia (CLL). However, there is substantial heterogeneity in the course of the disease. In recent years, molecular and cellular markers have helped to predict the prognosis of patients with CLL. Genomic aberrations subdivide CLL into distinct clinical subgroups. Fluorescence in situ hybridization (FISH) can identify genomic aberrations in approximately 80% of CLL cases. Furthermore, innovations in chromosome banding analyses, novel genome-wide approaches (ie, array– comparative genomic hybridization, single nucleotide polymorphism–chip), and sensitive mutation analyses have helped to characterize the critical aberrations and identify candidate genes for further refinement of genomic profiling. The most frequent aberrations are deletions in 13q, 11q, or 17p, and trisomy 12. Apart from providing insights into the pathogenesis of the disease, genomic aberrations identify subgroups of patients with distinct clinical pictures (lymphadenopathy [11q deletion] or resistance to chemotherapy [17p deletion]). Deletions in 11q and particularly 17p are associated with rapid disease progression or inferior survival, and patients with these genetic abnormalities might be candidates for clinical trials investigating alternative treatments and stem cell transplantation.</p></div>","PeriodicalId":100271,"journal":{"name":"Clinical Leukemia","volume":"1 4","pages":"Pages 217-222"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3816/CLK.2007.n.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74007033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resistance to Tyrosine Kinase Inhibitors in Philadelphia Chromosome-Positive Leukemias: Which Mutations Matter? 费城染色体阳性白血病对酪氨酸激酶抑制剂的耐药性:哪些突变重要?

Clinical Leukemia Pub Date : 2007-06-01 DOI: 10.3816/CLK.2007.n.012

Simona Soverini , Michele Baccarani , Ilaria Iacobucci , Giovanni Martinelli

{"title":"Resistance to Tyrosine Kinase Inhibitors in Philadelphia Chromosome-Positive Leukemias: Which Mutations Matter?","authors":"Simona Soverini , Michele Baccarani , Ilaria Iacobucci , Giovanni Martinelli","doi":"10.3816/CLK.2007.n.012","DOIUrl":"10.3816/CLK.2007.n.012","url":null,"abstract":"<div><p>The advent of imatinib, a potent and selective inhibitor of the Bcr-Abl tyrosine kinase whose deregulated expression drives Philadelphia chromosome-positive leukemias, has revolutionized outcome and quality of life of patients. However, resistance can develop through a variety of mechanisms, including point mutations in the Abl kinase domain, which are capable of abrogating inhibitor binding. The problem of resistance-associated mutations has fostered intensive research over the past 5 years. Herein, we review the current knowledge on the clinical significance of Abl kinase domain mutations in various settings. We discuss the contribution of mutations to imatinib resistance, and we hypothesize how the advent of novel tyrosine kinase inhibitors could change this scenario. We also warn against a systematic screening for Abl kinase domain mutations of imatinib-naive patients and patients who exhibit and maintain a complete cytogenetic response, because the practical relevance of finding rare mutated cells in these settings still needs to be confirmed.</p></div>","PeriodicalId":100271,"journal":{"name":"Clinical Leukemia","volume":"1 4","pages":"Pages 223-228"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3816/CLK.2007.n.012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82162167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Management of Acute Promyelocytic Leukemia Presenting During Pregnancy 妊娠期出现急性早幼粒细胞白血病的处理

Clinical Leukemia Pub Date : 2007-03-01 DOI: 10.3816/CLK.2007.n.006

Dominic J. Culligan , Luke Merriman , Jonathan Kell , Jane Parker , Jelena V. Jovanovic , Norman Smith , David Grimwade

{"title":"The Management of Acute Promyelocytic Leukemia Presenting During Pregnancy","authors":"Dominic J. Culligan , Luke Merriman , Jonathan Kell , Jane Parker , Jelena V. Jovanovic , Norman Smith , David Grimwade","doi":"10.3816/CLK.2007.n.006","DOIUrl":"10.3816/CLK.2007.n.006","url":null,"abstract":"<div><p>Acute promyelocytic leukemia is recognized to occur infrequently during pregnancy. The prognosis is good for acute promyelocytic leukemia with modern therapy including treatment with all-<em>trans</em>-retinoic acid that specifically targets the causative retinoic acid receptor (PML-RAR)α oncoprotein; however, the management of this disease in pregnancy is complex. This is because there are a number of possible treatment strategies that have varying implications for the mother and fetus. We describe a recent experience relating to 3 consecutive cases arising in the United Kingdom that demonstrates the different therapeutic decisions that can be taken and the various outcomes that can occur during pregnancy. In each case, treatment response was subject to stringent monitoring by real-time quantitative polymerase chain reaction for the <em>PML-RARA</em> fusion transcript. We have reviewed the available literature and, when possible, we have outlined the treatment strategies available for each stage of pregnancy.</p></div>","PeriodicalId":100271,"journal":{"name":"Clinical Leukemia","volume":"1 3","pages":"Pages 183-191"},"PeriodicalIF":0.0,"publicationDate":"2007-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3816/CLK.2007.n.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77244346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Mechanisms of Alemtuzumab-Mediated Cytotoxicity in Hematologic Malignancies 阿仑单抗介导的血液恶性肿瘤细胞毒性机制

Clinical Leukemia Pub Date : 2007-03-01 DOI: 10.3816/CLK.2007.n.004

Thomas S. Lin

引用次数: 0

Is JAK2 Moving Toward Prime Time in Essential (Primary) Thrombocythemia? JAK2是否在原发性血小板增多症中走向黄金时间?

Clinical Leukemia Pub Date : 2007-03-01 DOI: 10.3816/CLK.2007.n.001

Tariq I. Mughal MD (Associate Editor-in-Chief)

引用次数: 0

Meningeal Involvement in a Patient with Chronic Lymphocytic Leukemia and Richter's Transformation 慢性淋巴细胞白血病伴里希特氏转化患者脑膜受累

Clinical Leukemia Pub Date : 2007-03-01 DOI: 10.3816/CLK.2007.n.007

María de Lourdes Quintanilla-Dieck , Myriam Loyo , Zarir Karanjawala , Matthew Georgy , Douglas P. Clark , Michael Auerbach , Javier Bolaños-Meade

{"title":"Meningeal Involvement in a Patient with Chronic Lymphocytic Leukemia and Richter's Transformation","authors":"María de Lourdes Quintanilla-Dieck , Myriam Loyo , Zarir Karanjawala , Matthew Georgy , Douglas P. Clark , Michael Auerbach , Javier Bolaños-Meade","doi":"10.3816/CLK.2007.n.007","DOIUrl":"10.3816/CLK.2007.n.007","url":null,"abstract":"<div><p>Chronic lymphocytic leukemia (CLL) rarely involves the meninges. There are few cases published in the literature. In this report, we describe a 59-year-old man with an 8-year history of CLL who presented with bone marrow involvement and cytopenias; received therapy with rituximab, fludarabine, pentostatin, and cyclophosphamide; and later went on to receive alemtuzumab. He developed leptomeningeal infiltration presenting as diplopia. The cerebrospinal fluid revealed a white blood cell count of 51/mm<sup>3</sup>; all of them were mononuclear, and the diagnosis was confirmed to be CLL by flow cytometry. A gadolinium magnetic resonance imaging scan of the head showed abnormal enhancement extending from the choroids in the left ventricle into the right ventricle, as well as changes in intensity in the splenium of the corpus callosum and left cerebellar peduncle. Whole-brain irradiation (2500 cGy) and 5 cycles of intrathecal cytarabine were administered. After this, a diffuse large B-cell lymphoma of the right testicle was discovered. An orchiectomy was performed, followed by radiation to the testicular bed. Persistent leptomeningeal involvement was treated with intrathecal methotrexate, resulting in a remission. A matched, unrelated donor bone marrow transplantation was performed.</p></div>","PeriodicalId":100271,"journal":{"name":"Clinical Leukemia","volume":"1 3","pages":"Pages 192-194"},"PeriodicalIF":0.0,"publicationDate":"2007-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3816/CLK.2007.n.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91141728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1