Clinical Immunology Newsletter最新文献

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Homocysteine and immune injury 同型半胱氨酸与免疫损伤
Clinical Immunology Newsletter Pub Date : 1999-08-01 DOI: 10.1016/S0197-1859(00)88209-6
Norm granholm (Assistant Professor)
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引用次数: 1
Phagocytic recognition of apoptotic leukocytes 凋亡白细胞的吞噬细胞识别
Clinical Immunology Newsletter Pub Date : 1999-08-01 DOI: 10.1016/S0197-1859(00)88208-4
Krista L. Hess, Joan M. Cook-Mills
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引用次数: 0
Immune reconstitution after combination antiretroviral therapy 抗逆转录病毒联合治疗后的免疫重建
Clinical Immunology Newsletter Pub Date : 1999-08-01 DOI: 10.1016/S0197-1859(00)88206-0
Hernan Valdez
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引用次数: 0
Flow cytometry based procedures for the measurement of apoptosis applicable to the investigation of HIV infection 基于流式细胞术的细胞凋亡测定方法适用于HIV感染的研究
Clinical Immunology Newsletter Pub Date : 1999-08-01 DOI: 10.1016/S0197-1859(00)88207-2
Thomas W. Mc Closkey , Savita Pahwa
{"title":"Flow cytometry based procedures for the measurement of apoptosis applicable to the investigation of HIV infection","authors":"Thomas W. Mc Closkey , Savita Pahwa","doi":"10.1016/S0197-1859(00)88207-2","DOIUrl":"10.1016/S0197-1859(00)88207-2","url":null,"abstract":"","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"19 8","pages":"Pages 93-102"},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0197-1859(00)88207-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80988562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibrin(ogen) and inflammation: Current understanding and new perspectives 纤维蛋白(原)和炎症:当前的认识和新的观点
Clinical Immunology Newsletter Pub Date : 1999-08-01 DOI: 10.1016/S0197-1859(00)88210-2
Ashley P. DeAnglis, Gregory S. Retzinger
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引用次数: 8
Human herpesvirus 6 (hhv-6): Could it play a role in the etiopathogenesis of multiple sclerosis (ms)? 人类疱疹病毒6 (hhv-6):它是否在多发性硬化症(ms)的发病机制中起作用?
Clinical Immunology Newsletter Pub Date : 1999-06-01 DOI: 10.1016/S0197-1859(00)89203-1
MD L.F. Kastrukoff , MD, PhD E.E. Thomas
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引用次数: 0
Abstracts from the twelfth annual meeting of the association of medical laboratory immunologists (amli) 医学实验室免疫学家协会(amli)第十二届年会摘要
Clinical Immunology Newsletter Pub Date : 1999-06-01 DOI: 10.1016/S0197-1859(00)89204-3
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引用次数: 0
The human thymus: A new perspective on thymic function, aging, and hiv infection 人类胸腺:胸腺功能、衰老和hiv感染的新视角
Clinical Immunology Newsletter Pub Date : 1999-06-01 DOI: 10.1016/S0197-1859(00)89202-X
Carolyn M. Steffens , Giulia Marchetti , Alan Landay , Lena Al-Harthi
{"title":"The human thymus: A new perspective on thymic function, aging, and hiv infection","authors":"Carolyn M. Steffens ,&nbsp;Giulia Marchetti ,&nbsp;Alan Landay ,&nbsp;Lena Al-Harthi","doi":"10.1016/S0197-1859(00)89202-X","DOIUrl":"10.1016/S0197-1859(00)89202-X","url":null,"abstract":"<div><p>Shortly after birth, the human thymus begins a life long process of involution, whereby the net size of the thymus is not altered but the organ is replaced by adipose tissue. As a result, it has long been believed that thymic involution is indicative of a nonfunctional organ. Recently, however, with the use of computed tomography analysis and innovative molecular approaches that measure T-cell receptor circles, indicative of recent thymic emigrants, doubt has been placed on that dogma. The thymus appears to be active in thymopoiesis throughout the adult life, albeit inversely correlated with age. Being faced with diseases that deplete T-cells such as the acquired immunodeficiency syndrome (AIDS), this recent finding has the potential to exploit novel approaches that enhance thymic output as a mechanism to reconstitute the immune system. In this review, we will revisit the role of T-cells in immunity, the relationship between thymic function and age, and closely examine the impact of HIV-mediated thymic dysregulation on thymopoiesis.</p></div>","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"19 6","pages":"Pages 65, 72-79"},"PeriodicalIF":0.0,"publicationDate":"1999-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0197-1859(00)89202-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85899026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Immune reconstitution in lymphoid tissue following potent antiretroviral therapy 强效抗逆转录病毒治疗后淋巴组织的免疫重建
Clinical Immunology Newsletter Pub Date : 1999-06-01 DOI: 10.1016/S0197-1859(00)89201-8
MD, PhD Jan Andersson, PhD Thomas E. Fehniger
{"title":"Immune reconstitution in lymphoid tissue following potent antiretroviral therapy","authors":"MD, PhD Jan Andersson,&nbsp;PhD Thomas E. Fehniger","doi":"10.1016/S0197-1859(00)89201-8","DOIUrl":"10.1016/S0197-1859(00)89201-8","url":null,"abstract":"<div><p>During untreated HIV-1 infection, a chronic state of immune activation and inflammation develops at the lymphoid tissue sites of viral replication. The early effect of potent combination drug therapy is a reduction in peripheral viral burden and a reduction in the production of inflammatory and type 1 cytokines. Further along in treatment there are trends toward normalization in the frequencies of CD8<sup>8</sup> T-cells, CD4<sup>+</sup> CD45RA<sup>+</sup> cells, as well as CD4<sup>+</sup> CD45R0<sup>+</sup> cells. Finally, the CD1a<sup>+</sup> dendritic cell network is re-established and germinal centers are reformed. Although this restoration of the lymphoid dynamic form is coupled to a reconstitution of peripheral blood T-cell function in vitro and by skin testing, sterilizing immunity to HIV-1 does not develop. Furthermore there is no heightened development of cytotoxic CD8<sup>+</sup> T-cell function at the site of HIV-1 latency. This is evidenced by a massive recrudescence of HIV-1 viral replication within lymphoid tissue when therapy is stopped. The development of supplemental therapies, which reconstitute anti-HIV-1 immunity, will be required. Specific defects in anti-HIV-1 activity which occur in lymphoid tissue during infection include a downregulation of perform expression by cytotoxic T-cells, the down regulation of the TCR signal transducing chain CD3ζ, and inadequate CD4<sup>+</sup> T-cell help within the tissue compartment of immune regeneration.</p></div>","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"19 6","pages":"Pages 65-71"},"PeriodicalIF":0.0,"publicationDate":"1999-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0197-1859(00)89201-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79737289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Immunobiology of reproduction: Role of uniquely abundant NK cells in the placenta 生殖的免疫生物学:独特丰富的NK细胞在胎盘中的作用
Clinical Immunology Newsletter Pub Date : 1999-04-01 DOI: 10.1016/S0197-1859(00)89200-6
Daniel Rukavina, Gordana Laskarin, Natasa Strbo, Vlatka Sotosek, Tatjana Bogovic
{"title":"Immunobiology of reproduction: Role of uniquely abundant NK cells in the placenta","authors":"Daniel Rukavina,&nbsp;Gordana Laskarin,&nbsp;Natasa Strbo,&nbsp;Vlatka Sotosek,&nbsp;Tatjana Bogovic","doi":"10.1016/S0197-1859(00)89200-6","DOIUrl":"10.1016/S0197-1859(00)89200-6","url":null,"abstract":"","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"19 4","pages":"Pages 59-61"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0197-1859(00)89200-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77351126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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