Clinical eHealthPub Date : 2022-12-01DOI: 10.1016/j.ceh.2022.07.003
Lin Tong , Jiayuan Sun , Xiaoju Zhang , Di Ge , Yimin Yang , Jian Zhou , Dong Wang , Xin Hu , Hao Liu , Chunxue Bai
{"title":"Diagnostic value of tumor associated autoantibody panel in early detection of lung cancer in Chinese population: Protocol for a prospective, observational, and multicenter clinical trial","authors":"Lin Tong , Jiayuan Sun , Xiaoju Zhang , Di Ge , Yimin Yang , Jian Zhou , Dong Wang , Xin Hu , Hao Liu , Chunxue Bai","doi":"10.1016/j.ceh.2022.07.003","DOIUrl":"https://doi.org/10.1016/j.ceh.2022.07.003","url":null,"abstract":"<div><p>Lung cancer is the leading cause of cancer deaths. Although targeted therapies and programmed cell death protein 1 (PD-1) blockade have offered great advances, five-year survival rates remained low. Diagnosis of lung cancer at an earlier stage is the most efficient approach to improve survival. Tumor associated autoantibodies (TAAb) have been proven a promising innovative biomarker of lung cancer. We aimed to comprehensively evaluate the sensitivity, specificity, and accuracy of TAAbs in lung cancer detection, especially in early-stage patients, through a multicenter prospective observational clinical trial, and to screen out the novel combination of TAAbs with the best detection value for Chinese population. We aimed to enroll 1,400 participants from three clinical centers and divide into two cohorts. One cohort is participants with newly pathologically confirmed lung cancer as the case cohort, and the other is participants with benign nodules, matched healthy controls and other benign lung diseases as the control cohort. Cases and controls were randomly distributed into training or validation set. The level of 14 autoantibody candidates in their plasma were detected. A Monte-Carlo Simulated Annealing method was implemented to develop a composite panel of autoantibodies to distinguish between matched lung cancer cases and controls in the training set. The newly developed autoantibody panel was tested in the validation set for sensitivity, specificity and accuracy. This is the first and largest clinical trial designed to develop a novel autoantibody panel for lung cancer detection specifically for Chinese people. We performed a multicenter, prospective, observational study to find a novel panel of autoantibody markers that can help the diagnosis of lung cancer and the characterization of pulmonary nodules in Chinese population. The results may help to provide evidence-based recommendations to clinicians for lung cancer early detection and pulmonary nodule management. This study is registered in the <span>ClinicalTrials.gov</span><svg><path></path></svg> (NCT04216511).</p></div>","PeriodicalId":100268,"journal":{"name":"Clinical eHealth","volume":"5 ","pages":"Pages 67-71"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2588914122000181/pdfft?md5=318b40ac1071081a95c02c6659ff83ef&pid=1-s2.0-S2588914122000181-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91764412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical eHealthPub Date : 2022-09-01DOI: 10.1016/j.ceh.2022.09.001
Caroline Encinas Audibert, Adna de Moura Fereli Reis, R. Zazula, Regina Célia Bueno Rezende Machado, Suzana Maria Menezes Guariente, Sandra Odebrecht Vargas Nunes
{"title":"Development of digital intervention through a mobile phone application as an adjunctive treatment for bipolar disorder: MyBee Project","authors":"Caroline Encinas Audibert, Adna de Moura Fereli Reis, R. Zazula, Regina Célia Bueno Rezende Machado, Suzana Maria Menezes Guariente, Sandra Odebrecht Vargas Nunes","doi":"10.1016/j.ceh.2022.09.001","DOIUrl":"https://doi.org/10.1016/j.ceh.2022.09.001","url":null,"abstract":"","PeriodicalId":100268,"journal":{"name":"Clinical eHealth","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88350213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical eHealthPub Date : 2022-07-01DOI: 10.1016/j.ceh.2022.07.003
L. Tong, Jiayuan Sun, Xiaoju Zhang, D. Ge, Yiming Yang, Jian Zhou, Dong Wang, Xin Hu, Hao Liu, Chunxue Bai
{"title":"Diagnostic value of tumor associated autoantibody panel in early detection of lung cancer in Chinese population: protocol for a prospective, observational, and multicenter clinical trial","authors":"L. Tong, Jiayuan Sun, Xiaoju Zhang, D. Ge, Yiming Yang, Jian Zhou, Dong Wang, Xin Hu, Hao Liu, Chunxue Bai","doi":"10.1016/j.ceh.2022.07.003","DOIUrl":"https://doi.org/10.1016/j.ceh.2022.07.003","url":null,"abstract":"","PeriodicalId":100268,"journal":{"name":"Clinical eHealth","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81761733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stress and the impact of stressful events are lesser among raja yoga meditators – A cross sectional study during COVID-19 pandemic from India","authors":"Shobhika Madhu, Ramajayam Govindaraj, Prashant Kumar, Sushil Chandra","doi":"10.1016/j.ceh.2022.07.001","DOIUrl":"https://doi.org/10.1016/j.ceh.2022.07.001","url":null,"abstract":"","PeriodicalId":100268,"journal":{"name":"Clinical eHealth","volume":"29 1","pages":"58 - 66"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82623208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical eHealthPub Date : 2022-07-01DOI: 10.1016/j.ceh.2022.07.002
Meng-Hsien Sun, Linshan Xie, Yang Liu, Kecheng Li, Bin Jiang, Yeting Lu, Yuping Yang, Hai Yu, Yuanlin Song, Chunxue Bai, Dawei Yang
{"title":"The Metaverse in Current Digital Medicine","authors":"Meng-Hsien Sun, Linshan Xie, Yang Liu, Kecheng Li, Bin Jiang, Yeting Lu, Yuping Yang, Hai Yu, Yuanlin Song, Chunxue Bai, Dawei Yang","doi":"10.1016/j.ceh.2022.07.002","DOIUrl":"https://doi.org/10.1016/j.ceh.2022.07.002","url":null,"abstract":"","PeriodicalId":100268,"journal":{"name":"Clinical eHealth","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81108717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical eHealthPub Date : 2022-06-01DOI: 10.1016/j.ceh.2022.06.002
Mirjam van Orden, Jan C. Kraaijeveld, A. Spijker, Annemiek V. Silven, T. Bonten, N. Chavannes, A. van Dijke
{"title":"Evaluating the first results of a need-driven digital mental health intervention for depression and anxiety; an exploratory study","authors":"Mirjam van Orden, Jan C. Kraaijeveld, A. Spijker, Annemiek V. Silven, T. Bonten, N. Chavannes, A. van Dijke","doi":"10.1016/j.ceh.2022.06.002","DOIUrl":"https://doi.org/10.1016/j.ceh.2022.06.002","url":null,"abstract":"","PeriodicalId":100268,"journal":{"name":"Clinical eHealth","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78074521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical eHealthPub Date : 2022-06-01DOI: 10.1016/j.ceh.2022.06.001
N. Chavannes, Chunxue Bai
{"title":"Welcome to the new era of metaverse in medicine","authors":"N. Chavannes, Chunxue Bai","doi":"10.1016/j.ceh.2022.06.001","DOIUrl":"https://doi.org/10.1016/j.ceh.2022.06.001","url":null,"abstract":"","PeriodicalId":100268,"journal":{"name":"Clinical eHealth","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76213094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical eHealthPub Date : 2022-05-25DOI: 10.1016/j.ceh.2022.05.001
Linshan Xie, Man Huang, Wenye Geng, H. Kan, Jianwei Xuan, Yuanlin Song, Jinghong Li, Chunxue Bai, Dawei Yang
{"title":"A study of viral respiratory tract infections based on new smart terminals","authors":"Linshan Xie, Man Huang, Wenye Geng, H. Kan, Jianwei Xuan, Yuanlin Song, Jinghong Li, Chunxue Bai, Dawei Yang","doi":"10.1016/j.ceh.2022.05.001","DOIUrl":"https://doi.org/10.1016/j.ceh.2022.05.001","url":null,"abstract":"","PeriodicalId":100268,"journal":{"name":"Clinical eHealth","volume":"1 1","pages":"35 - 36"},"PeriodicalIF":0.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77285157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}