Clinical & Experimental Allergy Reviews最新文献_第5页

Role of cysteinyl leukotriene receptor antagonists in the management of allergic rhinitis 半胱氨酸白三烯受体拮抗剂在变应性鼻炎治疗中的作用

Clinical & Experimental Allergy Reviews Pub Date : 2008-07-10 DOI: 10.1111/j.1472-9733.2008.00136.x

H. Shirasaki, T. Himi

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引用次数: 0

Effect of H1-receptor antagonists on proliferative response, cytokine production, and cellular migration of human T cells and macrophages h1受体拮抗剂对人T细胞和巨噬细胞增殖反应、细胞因子产生和细胞迁移的影响

Clinical & Experimental Allergy Reviews Pub Date : 2008-07-10 DOI: 10.1111/j.1472-9733.2008.00132.x

S. Iwata, M. Nori, Y. Hashizume, K. You, C. Morimoto

{"title":"Effect of H1-receptor antagonists on proliferative response, cytokine production, and cellular migration of human T cells and macrophages","authors":"S. Iwata, M. Nori, Y. Hashizume, K. You, C. Morimoto","doi":"10.1111/j.1472-9733.2008.00132.x","DOIUrl":"10.1111/j.1472-9733.2008.00132.x","url":null,"abstract":"<div>\u0000 \u0000 Cytokine imbalance and cellular migration to inflammatory sites are critical components of allergic diseases. Redirecting cytokine imbalance and inhibiting cell migration therefore represent important therapeutic strategies for the treatment of these disorders. We studied the in vitro effect of the non-sedating H1-receptor antagonists ebastine, carebastine, epinastine, cetirizine, and ketotifen on cytokine secretion by human T cells under various co-stimulatory conditions and the migratory activity of activated T cells as well as production of pro-inflammatory cytokines by macrophages. Ebastine and carebastine inhibited T cell proliferation and production of IL-4, IL-5, IL-6, and TNF-α by T cells under co-stimulation with CD28 plus CD3, CD26 plus CD3, and CD3 plus phorbol myristate acetate, whereas these drugs had no effect on the production of IL-2 and IFN-γ. Ebastine and carebastine also inhibited T cell migration and production of TNF-α and IL-6 by macrophages. Epinastine inhibited T cell proliferation and production of IL-2, IFN-γ, IL-4, and IL-5, whereas it elicited no effect on the production of IL-6 and TNF-α by T cells and macrophages as well as T cell migration. Cetirizine and ketotifen had no effects on cytokine production and T cell migration. Our results suggest that certain H1-receptor antagonists, most notably ebastine and carebastine, can influence T cell migration and cytokine production in addition to antagonizing the H1 receptor. These drugs therefore might be useful against T cell-mediated allergic inflammatory disorders such as asthma, atopic dermatitis, and psoriasis.\u0000 </div>","PeriodicalId":100264,"journal":{"name":"Clinical & Experimental Allergy Reviews","volume":"8 2","pages":"21-29"},"PeriodicalIF":0.0,"publicationDate":"2008-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1472-9733.2008.00132.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"103655471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pilot study of Japanese cedar pollen exposure using a novel artificial exposure chamber (OHIO Chamber) 新型人工暴露室(OHIO chamber)对杉木花粉暴露的初步研究

Clinical & Experimental Allergy Reviews Pub Date : 2008-07-10 DOI: 10.1111/j.1472-9733.2008.00133.x

K. Hashiguchi, H. Tang, T. Fujita, K. Suematsu, S. Tsubaki, H. Nagakura, S. Kitajima, M. Gotoh, K. Okubo

{"title":"Pilot study of Japanese cedar pollen exposure using a novel artificial exposure chamber (OHIO Chamber)","authors":"K. Hashiguchi, H. Tang, T. Fujita, K. Suematsu, S. Tsubaki, H. Nagakura, S. Kitajima, M. Gotoh, K. Okubo","doi":"10.1111/j.1472-9733.2008.00133.x","DOIUrl":"10.1111/j.1472-9733.2008.00133.x","url":null,"abstract":"<div>\u0000 \u0000 For basic and clinical studies of Japanese cedar (JC) pollinosis and its treatment, experimental facilities for exposure to pollen under stable environmental conditions are becoming increasingly desirable. We developed an artificial exposure chamber (OHIO Chamber) that allows the dispersal of fixed concentrations of JC pollen in stable environments with a unique pollen supply system, air flow system for fixing the concentration of JC pollen, system for monitoring the number of pollen grains, and automated pure water washing and drying system. In the chamber, temperature and relative humidity (RH) could be successfully maintained at 22±1.1 °C and 45±5%, respectively. The spatial distribution of pollen concentrations in the chamber was within 10% of target, including when subjects were present. Only a few or no pollen grains were detected in the chamber after automatic washing and drying. We conducted a pilot tolerability and safety study in 15 JC pollinosis patients who were exposed to 15 000 pollen grains/m3 for 2 h. Symptoms manifested on average 33 min after start of exposure. The subjects experienced no serious side-effects, and pollen exposure at 15 000 grains/m3 was confirmed safe. After exposure, the number of intranasal and intraocular pollen grains was 469 and 602, respectively. The lower number of pollen grains in the nose than in the eyes was considered due to sneezing and nasal discharge. Further studies are needed to clarify the number of pollen grains required for the occurrence of symptoms in the OHIO Chamber.\u0000 </div>","PeriodicalId":100264,"journal":{"name":"Clinical & Experimental Allergy Reviews","volume":"8 2","pages":"30-36"},"PeriodicalIF":0.0,"publicationDate":"2008-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1472-9733.2008.00133.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"105496836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Allergic Rhinitis Forum 2007 过敏性鼻炎论坛2007

Clinical & Experimental Allergy Reviews Pub Date : 2008-07-10 DOI: 10.1111/j.1472-9733.2008.00131.x

Kimihiro Okubo, Yoshitaka Okamoto

引用次数: 0

Discussion session III: Airway wall remodelling 讨论会III：气道壁改造

Clinical & Experimental Allergy Reviews Pub Date : 2008-07-07 DOI: 10.1046/j.1472-9725.2001.00022.x

P Zimmerman Chairperson

引用次数: 0

New therapeutic indications for Cys-LT1 antagonists: chronic obstructive pulmonary disease Cys-LT1拮抗剂的新治疗适应症：慢性阻塞性肺病

Clinical & Experimental Allergy Reviews Pub Date : 2008-07-07 DOI: 10.1046/j.1472-9725.2001.00033.x

M Romagnoli, A Papi, F Luppi, L M Fabbri

引用次数: 0

Discussion session VI: New therapeutic indications for Cys-LT1 antagonists 讨论会VI：Cys-LT1拮抗剂的新治疗适应症

Clinical & Experimental Allergy Reviews Pub Date : 2008-07-07 DOI: 10.1046/j.1472-9725.2001.00037.x

C Lai Chairman

引用次数: 0

What does inflammation and airway remodelling mean? 炎症和气道重塑意味着什么？

Clinical & Experimental Allergy Reviews Pub Date : 2008-07-07 DOI: 10.1046/j.1472-9725.2001.00006.x

S T Holgate

引用次数: 7

Discussion session II: Inflammation 讨论会II：炎症

Clinical & Experimental Allergy Reviews Pub Date : 2008-07-07 DOI: 10.1046/j.1472-9725.2001.00016.x

E Von Mutius Chairman

引用次数: 0

The bronchial microcirculation 支气管微循环

Clinical & Experimental Allergy Reviews Pub Date : 2008-07-07 DOI: 10.1046/j.1472-9725.2001.00021.x

J W Wilson, S J Wilson

引用次数: 5