Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers最新文献

{"title":"Electrohydrodynamic Fabrication of Triple-layered Polycaprolactone Dura Mater Substitute with Antibacterial and Enhanced Osteogenic Capability","authors":"Yanwen Su ,&nbsp;Zhi Li ,&nbsp;Hui Zhu ,&nbsp;Jiankang He ,&nbsp;Boyuan Wei ,&nbsp;Dichen Li","doi":"10.1016/j.cjmeam.2022.100026","DOIUrl":"https://doi.org/10.1016/j.cjmeam.2022.100026","url":null,"abstract":"<div><p>In the field of dura mater repair, it is essential to employ artificial substitutes mimicking the multilayered microarchitecture and multiple functions of native dura mater for effective neurosurgery. However, existing artificial dura mater substitutes commonly cause complications because of mismatched structural and mechanical properties as well as the lack of antibacterial activity or osteogenic capability. In this study, a triple-layered dura mater substitute was fabricated by electrohydrodynamic (EHD) jetting techniques, including electrospinning and melt-based EHD printing processes. Highly aligned polycaprolactone (PCL) nanofibers loaded with gentamicin sulfate (GS) were prepared by electrospinning to form the inner layer, which can mimic the aligned collagen fibers of the native dura mater. Random PCL-GS nanofibers were then deposited by electrospinning to form the middle layer. They were intended to enhance the mechanical properties of the fabricated scaffolds. The outer layer involving PCL microfibers doped with nano-hydroxyapatite (nHA) at various angles was printed by the melting-based EHD method, which can enhance osteogenic capability and promote the fusion between the dura mater substitute and the skull. The tensile strength of the triple-layered drug-loaded biomimetic dura mater substitute was 22.42 ± 0.89 MPa, and the elongation at break was 36.43% ± 2.00%. The addition of GS endowed the substitutes with an anti-infection property without influencing their cytocompatibility. Furthermore, the incorporation of nHA promoted the osteogenic differentiation of MC3T3-E1 cells seeded on the triple-layered scaffolds. This work offers a promising strategy to manufacture multilayered dura mater substitutes with the desired antibacterial and enhanced osteogenic capability performance, possibly providing a novel candidate for dural tissue repair.</p></div>","PeriodicalId":100243,"journal":{"name":"Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers","volume":"1 2","pages":"Article 100026"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772665722000162/pdfft?md5=c484fe38dc8305f774631ed1a10f0112&pid=1-s2.0-S2772665722000162-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91759514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrohydrodynamic Fabrication of Triple-layered Polycaprolactone Dura Mater Substitute with Antibacterial and Enhanced Osteogenic Capability","authors":"Yanwen Su, Zhi Li, Huilin Zhu, Jiankang He, Boyuan Wei, Dichen Li","doi":"10.1016/j.cjmeam.2022.100026","DOIUrl":"https://doi.org/10.1016/j.cjmeam.2022.100026","url":null,"abstract":"","PeriodicalId":100243,"journal":{"name":"Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers","volume":"100 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91273547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coaxial Embedded Printing of Gelatin Methacryloyl–alginate Double Network Hydrogel for Multilayer Vascular Tubes","authors":"Min Ye ,&nbsp;Bingchuan Lu ,&nbsp;Xinyun Zhang ,&nbsp;Binhan Li ,&nbsp;Zhuo Xiong ,&nbsp;Ting Zhang","doi":"10.1016/j.cjmeam.2022.100024","DOIUrl":"10.1016/j.cjmeam.2022.100024","url":null,"abstract":"<div><p>The reconstruction of vascular-like tissues exhibiting a typical three-layer structure <em>in vitro</em> is vital to bio-fabrication research. It enables the realization of more complicated micro-environments, such as myocardium, liver, and tumor, which enables us to investigate their specific physiological phenomena or pathological mechanisms. Herein, we propose a coaxial embedded printing method, where the gelatin methacrylate (GelMA)–alginate composite hydrogel and sacrificial materials are extruded from a coaxial nozzle into a cylinder mold. By applying this method, we achieve the rapid fabrication of multilayer tube structures with inner diameters ranging from 400 to 1000 µm. In addition, myoblasts are encapsulated in the hydrogel, and the cells show high viability. Moreover, we encapsulate smooth muscle cells (SMCs) and the human umbilical vein endothelial cells–T1 (HUVEC-T1) cell line in the hydrogel to form vascular-like tissues, and the cells exhibit good morphology and protein expression. These results suggest that a vascular tube fabricated using the proposed method can serve as a vascular model for <em>in vitro</em> studies.</p></div>","PeriodicalId":100243,"journal":{"name":"Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers","volume":"1 2","pages":"Article 100024"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772665722000149/pdfft?md5=070667e25114401b85dbef9cab62bc75&pid=1-s2.0-S2772665722000149-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83008867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation, Microstructure, and Properties of ZrO2(3Y)/Al2O3 Bioceramics for 3D Printing of All-ceramic Dental Implants by Vat Photopolymerization","authors":"Lizheng Zhang ,&nbsp;Hao Liu ,&nbsp;Haihua Yao ,&nbsp;Yong Zeng ,&nbsp;Jimin Chen","doi":"10.1016/j.cjmeam.2022.100023","DOIUrl":"https://doi.org/10.1016/j.cjmeam.2022.100023","url":null,"abstract":"<div><p>Zirconia (ZrO₂) ceramics have potential applications in the field of oral medicine owing to their desirable mechanical properties, biocompatibility, chemical stability, and aesthetic properties. To realize clinical applications, ZrO₂(3Y)/Al₂O₃ bioceramics for all-ceramic dental implants were prepared using vat photopolymerization 3D printing technology, and their process optimization, microstructure, mechanics, tribology, and biological properties were studied. The results indicate that when the sintering temperature and holding time are 1600 °C and 3 h, respectively, the density of ZrO₂(3Y)/Al₂O₃ bioceramics reaches 98.79%, and its Vickers hardness, compressive strength, flexural strength, and fracture toughness also reach their maximum values. Furthermore, the <em>in vitro</em> simulated oral environment wear tests showed that artificial saliva provides a lubricating effect on ZrO₂(3Y)/Al₂O₃ bioceramics and improves wear resistance. The biosafety of ZrO₂(3Y)/Al₂O₃ bioceramics was evaluated and ZrO₂(3Y)/Al₂O₃ had no obvious cytotoxicity and promoted cell proliferation, growth, and adhesion. In addition, its surface has appropriate roughness and good wettability. In conclusion, ZrO₂(3Y)/Al₂O₃ bioceramics prepared by vat photopolymerization are promising biomaterials with broad application prospects in dental restoration.</p></div>","PeriodicalId":100243,"journal":{"name":"Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers","volume":"1 2","pages":"Article 100023"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772665722000137/pdfft?md5=0c195d430e74787f0555935b1e3dcb1a&pid=1-s2.0-S2772665722000137-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90126049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additive Manufacturing of Hydroxyapatite Bioceramic Scaffolds with Projection Based 3D Printing","authors":"H. Shao, Zhiheng Nian, Zhuoluo Jing, Tao Zhang, Jiahua Zhu, Xia Li, Youping Gong, Yongyan He","doi":"10.1016/j.cjmeam.2022.100021","DOIUrl":"https://doi.org/10.1016/j.cjmeam.2022.100021","url":null,"abstract":"","PeriodicalId":100243,"journal":{"name":"Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82863310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D Printing of Biodegradable Polymer Vascular Stents: A Review","authors":"Weijian Hua ,&nbsp;Weiliang Shi ,&nbsp;Kellen Mitchell ,&nbsp;Lily Raymond ,&nbsp;Ryan Coulter ,&nbsp;Danyang Zhao ,&nbsp;Yifei Jin","doi":"10.1016/j.cjmeam.2022.100020","DOIUrl":"10.1016/j.cjmeam.2022.100020","url":null,"abstract":"<div><p>Biodegradable polymer vascular stents (BPVSs) have been widely used in percutaneous coronary interventions for the treatment of coronary artery diseases. The development of BPVSs is an integrated process that combines material design/selection, manufacturing, and performance characterization. Three-dimensional (3D) printing technology is a powerful tool for polymer stent fabrication. Current review studies have focused primarily on the material and structural design of polymer stents but have failed to comprehensively discuss different 3D printing approaches and stent characterization techniques. In this paper, we address these shortcomings by discussing 3D printing methods and their application in BPVSs. First, some commonly used 3D printing methods (including material extrusion, vat polymerization, and powder bed fusion) and potential 3D printing strategies (including material jetting and binder jetting) for fabricating BPVSs are discussed; furthermore, the main post-treatments are summarized. Then, techniques to characterize the morphology, mechanical properties, and biological properties of the printed BPVSs are introduced. Subsequently, representative commercial BPVSs and lab-grade BPVSs are compared. Finally, based on the limitations of stent printing and characterization processes, future perspectives are proposed, which may help develop new techniques to fabricate more customized stents and accurately evaluate their performance.</p></div>","PeriodicalId":100243,"journal":{"name":"Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers","volume":"1 2","pages":"Article 100020"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772665722000101/pdfft?md5=465b6caa5c6445c582499a59df6cc39e&pid=1-s2.0-S2772665722000101-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75445226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-3D Printing","authors":"Dichen Li ,&nbsp;Zhuo Xiong","doi":"10.1016/j.cjmeam.2022.100027","DOIUrl":"10.1016/j.cjmeam.2022.100027","url":null,"abstract":"","PeriodicalId":100243,"journal":{"name":"Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers","volume":"1 2","pages":"Article 100027"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772665722000174/pdfft?md5=3885701193b1f5c1613e5841425ffa15&pid=1-s2.0-S2772665722000174-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91442233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roadmap for Additive Manufacturing: Toward Intellectualization and Industrialization","authors":"Xiaoyong Tian ,&nbsp;Lingling Wu ,&nbsp;Dongdong Gu ,&nbsp;Shangqin Yuan ,&nbsp;Yufan Zhao ,&nbsp;Xiao Li ,&nbsp;Liliang Ouyang ,&nbsp;Bo Song ,&nbsp;Tong Gao ,&nbsp;Jiankang He ,&nbsp;Xin Lin ,&nbsp;Feng Lin ,&nbsp;Jihong Zhu ,&nbsp;Dichen Li","doi":"10.1016/j.cjmeam.2022.100014","DOIUrl":"10.1016/j.cjmeam.2022.100014","url":null,"abstract":"<div><p>With the rapid development of Additive Manufacturing (AM) technology in the past 30 years, AM has been shifting from prototyping to advanced manufacturing of functional components in industry. Intellectualization and industrialization of AM process and equipment could be the bottlenecks to the wide industrial applications of AM technology in the future, which have been highlighted in this paper, aiming at describing the technological research roadmaps for the next 5 to 10 years. According to the data flow in the process and value chains of AM technologies, state-of-art of design methodology, material, process &amp; equipment, smart structures, and applications in extreme scales and environments has been elaborated respectively. Some suggestions on potential challenges for research and development in AM technologies have been provided in each section, which would finally establish a critical technical platform for the future industrial innovation and entrepreneurship.</p></div>","PeriodicalId":100243,"journal":{"name":"Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers","volume":"1 1","pages":"Article 100014"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772665722000046/pdfft?md5=0eeedfd9f6273869041e52734328dcf7&pid=1-s2.0-S2772665722000046-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81676362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in 3D Bioprinting","authors":"Yongcong Fang ,&nbsp;Yuzhi Guo ,&nbsp;Tiankun Liu ,&nbsp;Runze Xu ,&nbsp;Shuangshuang Mao ,&nbsp;Xingwu Mo ,&nbsp;Ting Zhang ,&nbsp;Liliang Ouyang ,&nbsp;Zhuo Xiong ,&nbsp;Wei Sun","doi":"10.1016/j.cjmeam.2022.100011","DOIUrl":"10.1016/j.cjmeam.2022.100011","url":null,"abstract":"<div><p>Three-dimensional (3D) bioprinting has emerged as a promising approach for engineering functional tissues and organs by layer-by-layer precise positioning of biological materials, living cells, and biochemical components. Compared with nonbiological printing, 3D bioprinting involves additional complexities and technical challenges owing to the processing of living cells, such as the appropriate biomaterials that fulfill the requirements for both printability and functionality. In this review, we first introduce the development course of 3D bioprinting, highlighting innovative forms of living building blocks and advances in enabling techniques of 3D bioprinting. We then summarize the state-of-the-art advancements in 3D bioprinting for biomedical applications, including macroscale tissue or organ bioprinting, disease modeling, microphysiological systems, biobots, and bioprinting in space. Despite the rapid development of 3D bioprinting over the past decades, most 3D bioprinted tissue or organ constructs are still far from being suitable for clinical translation, and it is necessary for the field of bioprinting to shift its focus from shape mimicking towards functionality development. Therefore, we provide our perspectives on this burgeoning field with an emphasis on functional maturation post printing and translational applications at the bedside.</p></div>","PeriodicalId":100243,"journal":{"name":"Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers","volume":"1 1","pages":"Article 100011"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772665722000010/pdfft?md5=d7be3f44ed1c0bbe5efc3ea6086dd6d2&pid=1-s2.0-S2772665722000010-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78569638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter from the Editors-in-Chief","authors":"","doi":"10.1016/j.cjmeam.2022.100015","DOIUrl":"10.1016/j.cjmeam.2022.100015","url":null,"abstract":"","PeriodicalId":100243,"journal":{"name":"Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers","volume":"1 1","pages":"Article 100015"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772665722000058/pdfft?md5=b605189d9b870b6d0698da5b459f347a&pid=1-s2.0-S2772665722000058-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77145815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}