Autonomic and Autacoid Pharmacology最新文献

{"title":"Autonomic and Autacoid Pharmacology: Goodbye and thank you","authors":"Peter Penson","doi":"10.1111/aap.12060","DOIUrl":"10.1111/aap.12060","url":null,"abstract":"","PeriodicalId":100151,"journal":{"name":"Autonomic and Autacoid Pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/aap.12060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35610902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attenuation of the anti-contractile effect of cooling in the rat aorta by perivascular adipose tissue","authors":"Y. Rafique,&nbsp;M. AlBader,&nbsp;M. Oriowo","doi":"10.1111/aap.12058","DOIUrl":"10.1111/aap.12058","url":null,"abstract":"<div>\u0000 \u0000 <p>\u0000 \u0000 </p><ol>\u0000 \u0000 \u0000 <li>In addition to providing mechanical support for blood vessels, the perivascular adipose tissue (PVAT) secretes a number of vasoactive substances and exerts an anticontractile effect. The main objective of this study was to find out whether the anticontractile effect of cooling in the rat aorta is affected by PVAT. Our hypothesis was that PVAT would enhance the anticontractile effect of cooling in the rat aorta.</li>\u0000 \u0000 \u0000 <li>Aorta segments, with or without PVAT, were used in this investigation. Cumulative concentration-response curves were established for phenylephrine at 37°C or 24°C. Phenylephrine (10^-9M – 10^-5M) induced concentration-dependent contractions of aorta segments with or without PVAT at 37°C. The maximum response, but not pD₂ value, was reduced in aorta segments with PVAT.</li>\u0000 \u0000 \u0000 <li>Cooling the tissues to 24 °C resulted in a significant reduction in the maximum response in aorta segments without PVAT with no change in pD₂ values. However, the anticontractile effect of cooling was attenuated in the presence of PVAT with no significant (p &gt; 0.05) change in either the maximum response or pD₂ value.</li>\u0000 \u0000 \u0000 <li>L-NAME potentiated PE-induced contractions and this was greater in aorta segments without PVAT at both temperatures.</li>\u0000 \u0000 \u0000 <li>The expression of eNOS protein and basal tissue level of nitric oxide (NO) were greater in aorta segments with PVAT at both temperatures. However, PE significantly increased tissue levels of NO only in aorta segments without PVAT.</li>\u0000 \u0000 \u0000 <li>We concluded that PVAT-induced loss of anticontractile effect of cooling against PE-induced contractions could be due to impaired generation of NO in aorta segments with PVAT.</li>\u0000 </ol>\u0000 \u0000 </div>","PeriodicalId":100151,"journal":{"name":"Autonomic and Autacoid Pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/aap.12058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35323822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Dopamine receptor immunohistochemistry in the rat choroid plexus.","authors":"","doi":"10.1002/aap.12061","DOIUrl":"https://doi.org/10.1002/aap.12061","url":null,"abstract":"<p><p>Retraction: F. Mignini, E. Bronzetti, L. Felici, A. Ricci, M. Sabbatini, S. K. Tayebati, F. Amenta (2000), Dopamine receptor immunohistochemistry in the rat choroid plexus. Journal of Autonomic Pharmacology, 20: 325-332. https://doi.org/10.1046/j.1365-2680.2000.00198.x The above article, published online on 09 October 2008, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by the Publisher John Wiley and Sons Ltd. This journal is no longer published by Wiley. Concerns were raised by a third party regarding suspected duplication and fabrication of elements within Figure 1. The Integrity Assurance and Case Resolution team evaluated the paper and found legitimate concerns affecting the reliability of Figure 1. The manuscript was published many years ago, and so the original data was not available for evaluation. As a result, the Integrity Assurance and Case Resolution team considers the conclusions of this manuscript invalid. The authors disagree with the retraction and the team´s evaluation.</p>","PeriodicalId":100151,"journal":{"name":"Autonomic and Autacoid Pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combinatorial effect of nicotine and black tea on heart rate variability: Useful or harmful?","authors":"S. Joukar,&nbsp;M. Sheibani","doi":"10.1111/aap.12059","DOIUrl":"10.1111/aap.12059","url":null,"abstract":"<div>\u0000 \u0000 <p>\u0000 \u0000 </p><ol>\u0000 \u0000 \u0000 <li>The effect of nicotine on heart rate variability (HRV) is controversial. Autonomic nervous system is the main regulator of heart rhythm, and heart rate variability is an appropriate index to assessment of the effects of the autonomic system on heart.</li>\u0000 \u0000 \u0000 <li>In this study, the combination effect of nicotine and black tea consumption on sympatho-vagal balance and heart rate variability was investigated in rats.</li>\u0000 \u0000 \u0000 <li>Male Wistar rats were randomized into four groups as control, tea (2.5 g/100 cc, daily), nicotine (2 mg/kg/d) and tea plus nicotine groups which treated for 28 days, and in the 29th day, their electrocardiograms (lead II) were recorded.</li>\u0000 \u0000 \u0000 <li>The mean of high-frequency power (HF) in tea, nicotine and tea plus nicotine groups was significantly more than control group (<i>P</i> &lt; .05), and low-frequency power/high-frequency power (LF/HF) ratio in the nicotine and tea + nicotine groups was significantly less than control group (<i>P</i> &lt; .05). LF values did not differ significantly among groups. Mean of standard deviation of normal RR intervals (SDNN) and square root of the mean squared differences of successive RR intervals (RMSSD) increased significantly in tea, nicotine and tea + nicotine groups in comparison with control group (<i>P</i> &lt; .05)</li>\u0000 \u0000 \u0000 <li>Overall, 4-week administration of black tea, nicotine or their combination with dosages used in this study can increase the heart rate variability and improve the sympatho-vagal balance in rat.</li>\u0000 </ol>\u0000 \u0000 </div>","PeriodicalId":100151,"journal":{"name":"Autonomic and Autacoid Pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/aap.12059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35420877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin prevents vascular prostanoid release alterations induced by a high-fat diet in rats","authors":"H. J. Lee,&nbsp;S. M. Cantú,&nbsp;A. S. Donoso,&nbsp;M. R. Choi,&nbsp;H. A. Peredo,&nbsp;A. M. Puyó","doi":"10.1111/aap.12057","DOIUrl":"10.1111/aap.12057","url":null,"abstract":"<div>\u0000 \u0000 <p>\u0000 \u0000 </p><ol>\u0000 \u0000 \u0000 <li>Perivascular adipose tissue dysfunction induced by high-fat feeding leads to alterations in the modulation of inflammation, contractile activity of the vascular smooth muscle and endothelial function, all risk factors in the development of hypertension. Metformin, an activator of AMP-activated protein kinase (AMPK), is currently the first-line drug treatment for type 2 diabetes (T2DM) and metabolic syndrome. Besides its glucose-lowering effect, there is an interest in actions of this drug with potential relevance in cardiovascular diseases.</li>\u0000 \u0000 \u0000 <li>The high-fat (HF) diet is an experimental model that resembles human metabolic syndrome. We have previously reported an altered pattern of prostanoid release in mesenteric vessels in this model.</li>\u0000 \u0000 \u0000 <li>The aim of this study was to analyse the effects of metformin on mesenteric vascular bed prostanoid release, adiposity index and its relation to blood pressure in Sprague-Dawley rats fed a HF diet for 8 and 12 weeks. Eight groups were used: control (C8, C1), HF diet (HF8, HF12, 50% w/w bovine fat), metformin-treated (CMf8, CMf12, 500 mg/kg/day) and metformin-treated HF diet (HFMf8, HFMf12, both treatments).</li>\u0000 \u0000 \u0000 <li>HF diet increased mesenteric vascular bed adiposity index (%, HF8: 1.7±0.1 vs C8: 0.9±0.04 and HF12: 1.8±0.1 vs C12: 0.8±0.1, <i>P</i>&lt;.001); systolic blood pressure (SBP, mm Hg, HF8: 145±6 vs C8: 118±4, <i>P</i>&lt;.01 and HF12: 151±1 vs C12: 121±3, <i>P</i>&lt;.001). We found a positive correlation between these two parameters. Moreover HF diet increased the release of vasoconstrictor prostanoids such as thromboxane (TX) B₂ (ng PR/mg of tissue, HF8: 117±6 vs C8: 66±2 and HF12: 123±6 vs C12: 62±5, <i>P</i>&lt;.001) and prostaglandin (PG) F_2α (ng/mg, HF8: 153±9 vs C8: 88±3 and HF12: 160±11 vs C12: 83±5, <i>P</i>&lt;.001). We also found that this increase in the release of vasoconstrictor prostanoids positively correlates with the elevation of SBP. In addition, HF diet increases the release of PGE₂ and decreases the prostacyclin (PGI₂)/TXA₂ release ratio at 8 and 12 weeks of treatment compared to control groups.</li>\u0000 \u0000 \u0000 <li>In the HFMf group, metformin treatment prevented all these increases in mesenteric vascular bed adiposity index (%, HFMf8: 1.3±0.2 vs HF8 and HFMf12: 1.3±0.1 vs HF12, <i>P</i>&lt;.05); SBP (mm Hg, HFMf8: 127±2 vs HF8 and HFMf12: 132±1 vs HF12, <i>P</i>&lt;.001); TXB₂ release (ng PR/mg of tissue, HFMf8: 65±12 vs HF8, <i>P</i>&lt;.05 and HFMf12: 53±3 vs HF12, <i>P</i>&lt;.001) and PGF₂α (ng PR/mg of tissue, HFMf8: 99±13 vs HF8, <i>P</i>&lt;.01 and HFMf12: 77±8 vs HF12, <i>P</i>&lt;.001). Meanwhile metformin prevented the increment in PGE₂ r","PeriodicalId":100151,"journal":{"name":"Autonomic and Autacoid Pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/aap.12057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35094716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"11,12-Epoxyeicosatrienoic acid induces vasodilator response in the rat perfused mesenteric vasculature","authors":"S. M. Bihzad,&nbsp;M. H. M. Yousif","doi":"10.1111/aap.12052","DOIUrl":"10.1111/aap.12052","url":null,"abstract":"<div>\u0000 \u0000 <p>\u0000 \u0000 </p><ol>\u0000 \u0000 \u0000 <li>Epoxyeicosatrienoic acids (EETs) are endogenous ligands that undergo hydrolysis by soluble epoxide hydrolase (sEH). The responses of 11, 12-EET in comparison with other vasodilator agonists including carbachol and sodium nitroprusside (SNP) were investigated. The effect of 1-cyclohexyl-3-dodecyl urea (CDU), a sEH, was tested on the vasodilator effect induced by 11, 12-EET in the perfused mesenteric beds isolated from normo-glycaemic and type-1 STZ-diabetic rats.</li>\u0000 \u0000 \u0000 <li>In the perfused mesenteric beds of control and diabetic animals, 11, 12-EET produced vasodilation in a dose-dependent manner. The vasodilator response induced by 11, 12-EET was significantly decreased in tissues obtained from diabetic animals, but this was significantly corrected through inhibition of sEH.</li>\u0000 \u0000 \u0000 <li>The effects of nitric oxide synthase inhibitor, cyclo-oxygenase inhibitor, specific potassium channel inhibitors, soluble guanylyl cyclase inhibitor and transient receptor potential channel V4 inhibitor, on vasodilator response to 11, 12-EET were investigated.</li>\u0000 \u0000 \u0000 <li>In tissues isolated from control animals, vasodilator responses to 11, 12-EET were not inhibited by acute incubation with <span>l</span>-NAME, <span>l</span>-NAME with indomethacin, glibenclamide, iberiotoxin, charybdotoxin, apamin or ODQ.</li>\u0000 \u0000 \u0000 <li>Incubation with the transient receptor potential channel V4 inhibitor ruthenium red caused significantly reduced vasodilator responses induced by 11, 12-EET.</li>\u0000 \u0000 \u0000 <li>In conclusion, results from this study indicate that 11, 12-EET has a vasodilator effect in the perfused mesenteric bed, partly through activation of vanilloid receptor. A strategy to elevate the levels of EETs may have a significant impact in correcting microvascular abnormality associated with diabetes.</li>\u0000 </ol>\u0000 \u0000 </div>","PeriodicalId":100151,"journal":{"name":"Autonomic and Autacoid Pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/aap.12052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34846119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiuretic and antinatriuretic response to high salt load in normotensive Wistar-Kyoto rats: Role of alpha-1A-adrenoreceptors","authors":"R. N. Kazi,&nbsp;M. A. Sattar,&nbsp;E. J. Johns","doi":"10.1111/aap.12053","DOIUrl":"10.1111/aap.12053","url":null,"abstract":"<div>\u0000 \u0000 <p>\u0000 \u0000 </p><ol>\u0000 \u0000 \u0000 <li>Altered renal adrenergic responses have been recognized as pathophysiological responses to high salt intake. This study aims to investigate the influence of 6 weeks of high salt diet on α_1A-adrenoceptor regulation of renal tubular antinatriuretic and antidiuretic response in normal Wistar Kyoto rats.</li>\u0000 \u0000 \u0000 <li>To achieve the above objective, antinatriuretic and antidiuretic response to phenylephrine was measured in the absence and presence of 5-methylurapidil (5-MeU) using the inulin clearance method. Systemic mean arterial blood pressure and renal haemodynamics were also measured simultaneously.</li>\u0000 \u0000 \u0000 <li>Six weeks of high salt intake in Wistar-Kyoto (WKY) rats did not bring any significant increase in mean arterial blood pressure. WKY rat on high salt diet (WKYHNa) showed an exaggerated increase in absolute and fractional sodium excretion. There was a significant involvement of α_1A-adrenoceptor in carrying out renal tubular antinatriuretic and antidiuretic response in Wistar Kyoto rats on normal sodium diet (WKYNNa). However, α_1A-adrenoceptor played a minimal role in handling the tubular reabsorptive response in WKY rats on high salt diet.</li>\u0000 </ol>\u0000 \u0000 </div>","PeriodicalId":100151,"journal":{"name":"Autonomic and Autacoid Pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/aap.12053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34846118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autonomic & Autacoid Pharmacology 2016: The year in review","authors":"P. E. Penson","doi":"10.1111/aap.12051","DOIUrl":"10.1111/aap.12051","url":null,"abstract":"","PeriodicalId":100151,"journal":{"name":"Autonomic and Autacoid Pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/aap.12051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85509230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Botulinum toxin A for palmar hyperhidrosis: assessment with sympathetic skin responses evoked by train of stimuli","authors":"J.Y. Al-Hashel,&nbsp;D. Youssry,&nbsp;H.M. Rashaed,&nbsp;T. Shamov,&nbsp;R.T. Rousseff","doi":"10.1111/aap.12050","DOIUrl":"10.1111/aap.12050","url":null,"abstract":"<div>\u0000 \u0000 <p>\u0000 \u0000 </p><ol>\u0000 \u0000 \u0000 <li>Objective assessment of the effect of botulinum toxin A (BT) treatment in primary palmar hyperhidrosis (PH) is attempted by different methods.</li>\u0000 \u0000 \u0000 <li>We decided to use for this purpose sympathetic skin responses evoked by train of stimuli (TSSR).</li>\u0000 \u0000 \u0000 <li>Twenty patients with severe PH (five female, median age 24, range 18-36) were examined regularly over 3 months after receiving 50 UI BT in each palm. TSSR were recorded from the palms after sensory stimulation by a train of three supramaximal electric pulses 3 millisecond apart. Results were compared to longitudinally studied TSSR of 20 healthy sex- and age-matched control subjects.</li>\u0000 \u0000 \u0000 <li>All hyperhidrosis patients reported excellent improvement. TSSR amplitudes decreased at week 1 (mean 54% range 48%-67%) and over the following months in a clinically significant trend (slope <i>R</i>=−.82, <i>P</i>&lt;.0001). TSSR in controls changed insignificantly (±13% from the baseline). The difference between patients and controls was highly significant at any time point (<i>P</i>&lt;.001).</li>\u0000 \u0000 \u0000 <li>This study suggests that TSSR may help in assessment of treatments in PH. It confirms objectively the efficacy of BT in PH.</li>\u0000 </ol>\u0000 \u0000 </div>","PeriodicalId":100151,"journal":{"name":"Autonomic and Autacoid Pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/aap.12050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85862923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increase in sensitivity of the baroreceptor reflex following microinjection of carbachol into the posterior hypothalamic nucleus of awake rats","authors":"C. R. Newey,&nbsp;J. R. Martin","doi":"10.1111/aap.12041","DOIUrl":"10.1111/aap.12041","url":null,"abstract":"<div>\u0000 \u0000 <p>\u0000 \u0000 </p><ol>\u0000 \u0000 \u0000 <li>In a rat model, the baroreceptor reflex can be assessed by graded infusions of either phenylephrine or sodium nitroprusside with continuous hemodynamic monitoring.</li>\u0000 \u0000 \u0000 <li>Microinjection of the cholinergic agonist carbachol (CCh) into the posterior hypothalamic nucleus (PHN) evokes an increase in mean arterial pressure and a change in heart rate. Lower doses of CCh evoke only tachycardia, whereas middle and higher doses evoke a biphasic change in heart rate of tachycardia followed by bradycardia.</li>\u0000 \u0000 \u0000 <li>The bradycardia following the microinjection of CCh into the PHN can be attenuated by the previous administration of the vasopressin V₁ receptor antagonist [d(CH₂)₅Tyr(Me)] arginine vasopressin (AVPX).</li>\u0000 \u0000 \u0000 <li>Circulating arginine vasopressin (AVP) has been shown to increase the sensitivity of the baroreceptor reflex by stimulating vasopressin V₁ receptors in the area postrema.</li>\u0000 \u0000 \u0000 <li>The attenuation by AVPX of the bradycardia that results following the high doses of CCh suggests that AVP is released into the circulation following stimulation of cholinergic systems within the PHN.</li>\u0000 \u0000 \u0000 <li>Thus, microinjection of a high dose of CCh (11 nmol) into the PHN alters the sensitivity of the baroreceptor reflex by increasing peripheral levels of AVP.</li>\u0000 </ol>\u0000 \u0000 </div>","PeriodicalId":100151,"journal":{"name":"Autonomic and Autacoid Pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/aap.12041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34331042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}