中国全科医学最新文献

{"title":"Development of the COVID-19 Cluster Containment Evaluation System Using the Emergency Management Theory","authors":"Jue Liu, Wannian Liang, Min Liu, Weizhong Yang, Xia Liu, Jing Wu, Yadong Wang, G. Shan, H. Han, Lei Zhou","doi":"10.12114/J.ISSN.1007-9572.2021.00.528","DOIUrl":"https://doi.org/10.12114/J.ISSN.1007-9572.2021.00.528","url":null,"abstract":"","PeriodicalId":10013,"journal":{"name":"中国全科医学","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46299604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features and Prognostic Risk Factors of COVID-19 in Adults: a Retrospective Analysis of 93 Cases","authors":"M. Ai, Tong-Zeng Li, Longyu Zhang, Hui Xu, D. Mou, Lian-chun Liang","doi":"10.12114/J.ISSN.1007-9572.2021.00.056","DOIUrl":"https://doi.org/10.12114/J.ISSN.1007-9572.2021.00.056","url":null,"abstract":"Background: Since April 2020, the number of newly diagnosed cases and death cases of COVID-19 have decreased significantly in China but increased rapidly abroad Early diagnosis and treatment are of great concern to improving the prognosis of COVID-19 patients Objective: To investigate the clinical features and prognostic risk factors of adult patients with COVID-19, offering a reference for clinical diagnosis and treatment of this disease Methods: A retrospective design was used Participants were 93 adult cases of COVID-19 who were treated in Beijing Youan Hospital between January and February 2020 They were categorized into common, severe and critical types by the most serious conditions during hospitalization, in accordance with the Diagnosis and Treatment Protocol for COVID-19(Trial Version 7)issued by the National Health Commission of the People's Republic of China Indications such as general information, major clinical manifestations, baseline laboratory parameters, APACHE II and SOFA scores within 24 hours of admission, imaging findings, comorbidities and complications, treatments and outcomes were collected Results: There were 57 cases of common type(61 3%), 22 of severe type(23 7%)and 14 of critical type(15 0%) The male ratio was slighter higher in critical group, and female ratio was slighter higher in other groups, but sex composition showed no significant differences across the groups(P>0 05) The median age for common, severe and critical groups was 45 0, 62 0 and 81 0 years, respectively, showing significant differences(P0 05) Dyspnea occurred in all severe or critical cases, showing a higher incidence than common cases(100 0% vs 31 6%)(P<0 05) The incidence of lymphocytopenia in critical group was 100%, which was significantly higher than that in common group(49 1%)or severe group(59 1%)(P<0 05) Acute liver injury was the most common complication(58 1%)in all cases, but its incidence was obviously increased in severe group (77 3%) or critical group(92 9%), than that of common group(42 1%)(P<0 05) Chinese medicine therapy was used in 75 3% of all cases, but the severe cases had a higher rate of treating with Chinese medicine than critical cases(90 9% vs 50 0%, P<0 05) The rate of corticosteroid use in severe cases(63 6%)or critical cases(64 3%)was significantly increased than that of common cases(5 3%)(P<0 05) Six patients(6 5%)were treated with invasive ventilation, but only 1 of them(16 7%)was successfully extubated ultimately Nine patients(9 7%)died in hospital due to all causes Logistic regression analysis revealed that age ≥74 years〔OR(95%CI)=33 714(3 021, 376 211), P=0 004〕and baseline SOFA≥2 5〔OR(95%CI)=15 447(1 331, 179 260), P=0 029〕were independent risk factors for in-hospital death Conclusion: COVID-19 mainly manifests as respiratory infections Severe patients are apt to appear tissue injury and dysfunction of organs like liver, kidney and heart, etc The majority of patients have a favorable outcome Age and baseline SOFA sc","PeriodicalId":10013,"journal":{"name":"中国全科医学","volume":"24 1","pages":"196-204"},"PeriodicalIF":0.0,"publicationDate":"2021-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44578841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thinking, Judgement and Decision Making in the Prevention and Control of COVID-19","authors":"L. Piterman","doi":"10.12114/j.issn.1007-9572.2021.00.293","DOIUrl":"https://doi.org/10.12114/j.issn.1007-9572.2021.00.293","url":null,"abstract":"","PeriodicalId":10013,"journal":{"name":"中国全科医学","volume":"24 1","pages":"3171-3174"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66051971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Indicators for Severity in COVID-19 Patients:a Meta-analysis","authors":"J. Wang, J. Li, Y. Tian, Y. Li","doi":"10.12114/j.issn.1007-9572.2021.00.548","DOIUrl":"https://doi.org/10.12114/j.issn.1007-9572.2021.00.548","url":null,"abstract":"Background The COVID-19 has become a global pandemic declared by the WHO, and the severity of which affects the prognosis of patients. Objective To explore the prognostic indicators for severity and their predictive values in COVID-19 patients, providing a reference for clinical prediction of patients'outcome and prognosis. Methods Eight databases (The Cochrane Library, Embase, PubMed, Web of Science, SinoMed, CNKI, Wanfang Data Knowledge Service Platform, VIP)were searched from inception to 2020-09-03 for randomized controlled trials(RCTs)about severe versus non-severe COVID-19 patients or deceased versus survived COVID-19 patients with prognostic indicators〔including procalcitonin (PCT), C-reactive protein (CRP), lymphocyte count (LYM), interleukin-6 (IL-6), D-dimer〕studied. The modified Jaded Scale was used to assess the methodological quality. Stata 12.0 was used for meta-analysis. Results Fifteen RCTs were included, involving 1 476 cases, all were assessed with high methodological quality(modified Jadad Scale score ranging from 4 to 5 points). Meta-analysis found that severe COVID-19 patients had higher mean values of PCT〔SMD=-2.28, 95%CI (-3.60, -0.98), P<0.001〕, CRP〔SMD=-2.23, 95%CI (-3.38, -1.07), P<0.001〕, IL-6〔SMD=-2.97, 95%CI (-4.94, -1.00), P<0.001〕, and D-dimer〔SMD=-1.22, 95%CI (-2.66, 0.21), P=0.008〕than non-severe COVID-19 patients. Severe COVID-19 patients had lower mean LYM〔SMD=1.41, 95%CI (0.34, 2.48), P<0.001〕. The deceased COVID-19 patients had higher mean values of PCT〔SMD=-4.11, 95%CI (-9.98, 1.76), P=0.007〕, CRP〔SMD=-2.73, 95%CI (-4.21, -1.25), P<0.001〕, IL-6〔SMD=-3.79, 95%CI (-4.90, -2.67), P<0.001〕, and D-dimer〔SMD=-0.68, 95%CI (-1.46, 0.09), P=0.009〕 than the survived.The deceased COVID-19 patients had lower mean LYM 〔SMD=2.08, 95%CI (0.93, 3.22), P<0.001〕. Conclusion Increased PCT, CRP, IL-6 and D-dimer and decreased LYM were found in severe or deceased COVID-19 patients, indicating that the former three may be positively correlated with severity, while the latter may be negatively correlated with severity. These five indicators may be used as prognostic indicators for severity, too high PCT, CRP, IL-6 and D-dimer, and too low LYM may suggest a poor prognosis. Copyright © 2021 by the Chinese General Practice.","PeriodicalId":10013,"journal":{"name":"中国全科医学","volume":"24 1","pages":"2594-2600"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66051714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difficulties and Solutions for the Family Doctor Team in Preventing and Managing Public Health Emergencies: a Study Using the Value Chain Approach","authors":"Y. Guo, X. Zhu, Z. Zeng","doi":"10.12114/j.issn.1007-9572.2021.00.272","DOIUrl":"https://doi.org/10.12114/j.issn.1007-9572.2021.00.272","url":null,"abstract":"Background: Currently, the family doctor team still faces many obstacles in managing public health emergencies as the gatekeeper. However, there is little research on the difficulties of family doctor teams in the prevention and management of public health emergencies. Objective: To explore the difficulties of family doctor teams in the prevention and management of public health emergencies, providing a theoretical basis and recommendations on ensuring the highly efficient performance of family doctor teams in preventing and managing the emergencies. Methods: Convenience sampling was used to select frontline healthcare workers from 25 primary healthcare institutions of Guangzhou to complete an online survey using a self-administered questionnaire conducted in June 2020 for investigating the implementation of essential public health services, essential medical services and prevention and management of public health emergencies in their hospitals between February and June 2020. Interviews were conducted with some of the healthcare workers who volunteered to be interviewed. Results: According to the questionnaire survey, during February to June 2020, of the 25 institutions, 19 had halted the delivery of some or all essential public health services, 6 had no capacities and channels to transfer suspected or confirmed COVID-19 cases to designated COVID-19 hospitals, 24 had implemented the emergency response plan for the COVID-19 pandemic, 10 had offered COVID-19-related health education, 9 had not set up the infectious diseases and public health emergencies reporting and managing system, 10 had not established the fever clinic, and 11 had operated all the clinics as usual. Value chain analysis of the interviews indicated that difficulties faced by the family doctor team in preventing and managing public health emergencies were: insufficient in-hospital support, unsuccessful communication and collaboration between hospitals or between the hospital and other institutions, poor monitoring and early warning effect of the COVID-19 pandemic, insufficient COVID-19-related health education, residents' unmet needs of essential medical services, inadequate emergency response infrastructure, lack of public health professionals, discrepancy between the construction of various information systems, inappropriate emergency procurement system. Conclusion: To make the community a solid fortress for the prevention and management of public health emergencies to ensure residents' health and safety, the authors suggest that efforts shall be made to address the barriers to the implementation of essential medical services first, then to solve issues existing in the implementation of auxiliary services. Copyright © 2021 by the Chinese General Practice.","PeriodicalId":10013,"journal":{"name":"中国全科医学","volume":"24 1","pages":"3190-3196"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66051847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active Screening, Comprehensive Evaluation, Tiered Diagnosis and Management of Diabetic Foot: Essentials of Screening, Diagnostic and Therapeutic Strategies","authors":"A. Wang, W. Zhao","doi":"10.12114/j.issn.1007-9572.2021.00.564","DOIUrl":"https://doi.org/10.12114/j.issn.1007-9572.2021.00.564","url":null,"abstract":"Diabetic foot is a major cause of diabetes-related disability and mortality, which imposes a tremendous social and economic burden on individuals and society due to high recurrence rate and healthcare expenditure. Diabetic foot ulcer is the most common manifestation of diabetic foot, and the main reason of limb amputation. Complicated disease state, poor general physical conditions, severe infection, and poor outcomes are the features of Chinese patients with diabetic foot ulcer.Moreover, inadequate screening and evaluation, as well as nonstandard diagnosis and treatment still exist clinically. This commentary highlights the value of active screening and early intervention for patients with a high risk of diabetic foot, comprehensive evaluation for diabetic foot patients, using a multidisciplinary approach for tiered diagnosis and treatment, and new model for the management of diabetic foot under regular containment of COVID-19. Copyright © 2021 by the Chinese General Practice.","PeriodicalId":10013,"journal":{"name":"中国全科医学","volume":"24 1","pages":"3013-3018"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66051822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration on the Detection Results of 2019 Novel Coronavirus Antibodies in the Real World","authors":"J. Dai, B. Lin, X. Sun","doi":"10.12114/j.issn.1007-9572.2021.01.302","DOIUrl":"https://doi.org/10.12114/j.issn.1007-9572.2021.01.302","url":null,"abstract":"Background: In the early stage of COVID-19, the colloidal gold method was the first to be approved by the National Medical Products Administration for clinical use, but the interfering factors of false positive antibody test results are still unclear. Objective: To explore how to analyze and interpret the positive results of COVID-19 antibody test in clinical practice. Methods: A total of 8 678 patients simultaneously submitted for SARS-CoV-2 IgM/IgG antibody and nucleic acid in Peking University International Hospital from March to June 2020 for retrospective analysis were included in the inretrospective analysis. The epidemiological history, clinical manifestations and laboratory indicators(including SARS-CoV-2 IgM/IgG antibody and nucleic acid, rheumatoid factor, complement, immunoglobulin). The colloidal gold method was used to detect the SARS-CoV-2 IgM/IgG antibody, and the positive check of the antibody was performed by the magnetic particle chemiluminescence method. RT-PCR method was adopted to detect SARS-CoV-2 nucleic acid. The heterophilic antibody blocking tube(HBT)was used to process the specimens that were positive by the colloidal gold method, and then the test was performed again. Results: (1)Among the 8 678 patient specimens submitted for examination, 8 677 were negative for SARS-CoV-2 nucleic acid detection, of which 25 cases(0.288%)were positive for SARS-CoV-2 IgM antibody detected by colloidal gold method, SARS-CoV-2 -5 patients(0.058%)with IgG antibody positive, and 0 patients with SARS-CoV-2 IgM and SARS-CoV-2 IgG antibodies at the same time.(2)Thirty patients who tested positive for SARS-CoV-2 antibody by colloidal gold method had no epidemiological history, and at the same time, the results of SARS-CoV-2 nucleic acid test were negative. The possibility of SARS-CoV-2 infection or previous SARS-CoV-2 infection was ruled out. Among them, 10 patients with positive SARS-CoV-2 IgM antibody were still positive after more than 2 times of dynamic monitoring, and the remaining 20 patients were not clinically active monitored.(3)The false positive rate of SARS-CoV-2 IgM antibody detected by colloidal gold method was 0.288%, and the false positive rate of SARS-CoV-2 IgG antibody was 0.058%. After HBT was used to process the SARS-CoV-2 colloidal gold-positive specimens, among the 25 SARS-CoV-2 IgM antibody-positive specimens, except for 1 case which was still positive, the other results became negative;the results of 5 specimens with positive SARS-CoV-2 IgG antibody were still positive.(4)The rheumatoid factor, complement and immunoglobulin levels of 30 SARS-CoV-2 antibody-positive patients were within the normal reference range. Conclusion: The SARS-CoV-2 antibody test results may have false positives. The majority of SARS-CoV-2 IgM antibody positives are caused by heterophilic antibody interference. Those with SARS-CoV-2 IgG antibody positive may also have other potentially unknown interference factors. Heterophile antibodies interfer","PeriodicalId":10013,"journal":{"name":"中国全科医学","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66052607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the Development of Public Health Emergency Preparedness and Response System via Reinforcing Primary Care in Pandemic and Non-pandemic Periods","authors":"J. Huang, H. Huang, H. Liang, F. Fang, Y. Cui, C. Chen, S. Chen, L. Tang, Z. Wang, W. Chang, Y. Yao","doi":"10.12114/j.issn.1007-9572.2021.00.247","DOIUrl":"https://doi.org/10.12114/j.issn.1007-9572.2021.00.247","url":null,"abstract":"Background: Since the outbreak of COVID-19, the ability to manage public health emergencies in mega-cities has been put on the policy agenda, and the role of primary care in public health system is critical. Objective: To explore the status, problems and challenges of practical exploration of Shanghai's primary care in responding to COVID-19, providing policy recommendations and decision-making basis for improving the public health emergency system. Methods: From June to September 2020, a qualitative study was conducted using group interviews with administrators and healthcare professionals selected from 10 representative community health centers(CHCs) in suburban, fringe and urban areas in Shanghai's 5 districts for exploring major tasks shouldered by the CHCs, organizational structure of the CHCs, actual tasks performed by the CHCs, internal collaboration, major problems in service delivery during the pandemic, and recommendations, and with directors, as well as professionals responsible for information, healthcare management and quality control, public emergency management and infectious disease containment selected from health commissions and centers for disease control and prevention in the districts, for exploring the functions and roles of CHCs during the pandemic and their weaknesses in anti-pandemic actions, anti-pandemic supports from health commissions and centers for disease control and prevention for CHCs, and ideas about actions of primary care in pandemic and non-pandemic periods. The interviews with individuals from three kinds of affiliations were guided using different types of semi-structured outlines developed by our research team. Results: The interviews revealed that during the pandemic, the CHCs gave emergency responses to COVID-19, participated in regional collaboration for COVID-19 containment, delivered in-hospital COVID-19 screening and triage services while providing routine medical services, and continued to offer family doctor services. Four issues were found to be addressed: insufficient healthcare resources and workers, insufficient services targeting psychological influence of COVID-19, unsatisfied internal coordination and multi-departmental management, and lack of appropriate mechanisms incentivizing healthcare workers and invigorating primary care. Conclusion: In view of the challenges in fighting COVID-19 faced by primary care, it is recommended to take actions on the basis of appropriately balancing the delivery of routine primary care services and public health services, and tasks during pandemic and non-pandemic periods, and appropriately coordinating with higher level departments, as well as developing incentive programs according to the local conditions as a supplement for the government programs. Copyright © 2021 by the Chinese General Practice.","PeriodicalId":10013,"journal":{"name":"中国全科医学","volume":"24 1","pages":"3184-3189"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66051836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious Disease Prevention and Control Capacity of Community Health Institutions in Beijing: Current Status and Recommendations for Problems","authors":"N. Su, X. Xu, R. Zhu, X. Zhang, J. Yu","doi":"10.12114/j.issn.1007-9572.2021.00.275","DOIUrl":"https://doi.org/10.12114/j.issn.1007-9572.2021.00.275","url":null,"abstract":"Background: During the fight against the COVID-19 pandemic, Beijing's community health institutions showed some weaknesses in infectious disease prevention and control. To improve their capabilities in this aspect to fully play their role as a sentinel for monitoring infectious diseases, it is urgent to investigate and analyze their current status to find problems, then put forward recommendations. Objective: To investigate the infectious disease prevention and control level in Beijing's community health institutions, and identify and analyze the problems, with suggestions put forward. Methods: From May to July 2020, a questionnaire survey was conducted in all community health centers(CHCs) in Beijing. Information was collected, including the basic situation, departments, staff structure, infrastructure situation, the provision of public health services, and emergency response capacity for infectious diseases and public health emergencies of the CHC, and was analyzed using descriptive analysis. The above-mentioned data were checked and supplemented if necessary in accordance with the information in the China's National COVID-19 Surveillance Network and Beijing Community Health Statistics 2019. Results: Of the 342 CHCs in total in Beijing as of 2019, 90(26.32%) had a fever clinic, 102(29.82%) had a gastrointestinal clinic, and 54(15.79%) had both a fever clinic and a gastrointestinal clinic. Among the incumbent workers in the CHCs(n=28 809), 2 887(10.02%) held a position in public health, and 178(6.17%) had a senior professional title. HIV testing was carried out in 159 CHCs(46.49%). SARS-CoV-2 nucleic acid testing was accessible in 11 CHCs(3.22%). For 29 kinds of common infectious diseases, 140(40.94%) CHCs had no diagnosis and treatment capabilities, 135(39.47%) had capabilities managing 1-5 kinds, only 29(8.48%) were able to diagnose and treat >10 kinds. Conclusion: The CHCs in Beijing may have a series of problems in the infectious disease prevention and control system and mechanism, sentinel fever clinic, infectious disease diagnosis and treatment capacity, public health workforce development and other aspects. Therefore, the infectious disease prevention and control plan of the CHCs should be developed more appropriately from an overall point of view, to address the problems and improve the current status as soon as possible. Copyright © 2021 by the Chinese General Practice.","PeriodicalId":10013,"journal":{"name":"中国全科医学","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66051893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Developments in the Pathogenesis of COVID-19-associated Myocarditis","authors":"F. Luo, S. Li, X. Hao, Y. Bai, K. Yuan, Y. Xie","doi":"10.12114/j.issn.1007-9572.2021.00.524","DOIUrl":"https://doi.org/10.12114/j.issn.1007-9572.2021.00.524","url":null,"abstract":"Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)was initially thought to mainly affect the respiratory system. A growing body of research has found that SARS-CoV-2 infection can affect multiple human organ systems, and heart is a major target organ secondary to lung. COVID-19-associated cardiac injury is often seen clinically, about 1%-7% of which is myocarditis. COVID-19-associated myocarditis often has a poor outcome. However, the possible pathogenesis mechanisms of COVID-19-associated cardiac injury, and its progression to COVID-19-associated myocarditis, as well as related pathophysiological changes are still unknown. Available data analysis has revealed that the recognized mechanism of cardiac injury in COVID-19 is ACE2-mediated cardiac injury, and cytokine storm-mediated or immune-mediated cardiac injury is only suggestive currently. Due to limited use of cardiac MRI and endocardial biopsy as well as insufficient autopsy findings and other basic research data in patients with COVID-19-associated myocarditis, the diagnosis and treatment of COVID-19-associated myocarditis are challenges that still exist for clinicians. We reviewed the possible pathophysiological mechanisms of COVID-19-associated myocarditis, which will contribute to improving medical workers' understanding of this disease so that its related mortality may be reduced. Copyright © 2021 by the Chinese General Practice.","PeriodicalId":10013,"journal":{"name":"中国全科医学","volume":"24 1","pages":"2589-2593"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66052155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}