APS JournalPub Date : 1994-12-01Epub Date: 2005-08-01DOI: 10.1016/S1058-9139(05)80277-3
Robert G. Large
{"title":"Advantages of illness","authors":"Robert G. Large","doi":"10.1016/S1058-9139(05)80277-3","DOIUrl":"10.1016/S1058-9139(05)80277-3","url":null,"abstract":"","PeriodicalId":100112,"journal":{"name":"APS Journal","volume":"3 4","pages":"Pages 282-284"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1058-9139(05)80277-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89947276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
APS JournalPub Date : 1994-12-01Epub Date: 2005-08-01DOI: 10.1016/S1058-9139(05)80272-4
J.L. Henry, V. Radhakrishnan
{"title":"Hyperalgesia following noxious thermal, mechanical, or chemical stimulation involves overlapping spinal mechanisms and interactive participation of excitatory amino acids and neuropeptides","authors":"J.L. Henry, V. Radhakrishnan","doi":"10.1016/S1058-9139(05)80272-4","DOIUrl":"10.1016/S1058-9139(05)80272-4","url":null,"abstract":"","PeriodicalId":100112,"journal":{"name":"APS Journal","volume":"3 4","pages":"Pages 249-256"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1058-9139(05)80272-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91442581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
APS JournalPub Date : 1994-12-01Epub Date: 2005-08-01DOI: 10.1016/S1058-9139(05)80278-5
David A. Fishbain
{"title":"Response to Drs. Gallagher, King, and Large","authors":"David A. Fishbain","doi":"10.1016/S1058-9139(05)80278-5","DOIUrl":"10.1016/S1058-9139(05)80278-5","url":null,"abstract":"","PeriodicalId":100112,"journal":{"name":"APS Journal","volume":"3 4","pages":"Page 285"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1058-9139(05)80278-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80363180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
APS JournalPub Date : 1994-12-01Epub Date: 2005-08-01DOI: 10.1016/S1058-9139(05)80269-4
S.T. Meller
{"title":"Thermal and mechanical hyperalgesia","authors":"S.T. Meller","doi":"10.1016/S1058-9139(05)80269-4","DOIUrl":"10.1016/S1058-9139(05)80269-4","url":null,"abstract":"<div><p>The mechanisms underlying hyperalgesia have been intensively studied over the last decade using a variety of molecular, electrophysiological, and behavioral approaches. These experiments have led to the generalized scheme that persistent nociceptor input, as a result of tissue or nerve injury, removes a magnesium block on spinal NMDA receptors, allowing for calcium influx, translocation of protein kinase C, and activation of nitric oxide synthase and soluble guanylate cyclase as important central components of hyperalgesia. However, the hypothesis proposed here suggests a need for a critical reevaluation of the generalized applicability of these events to our understanding of the mechanisms of hyperalgesia. It is proposed that thermal and mechanical hyperalgesia rely on activation of two different intracellular cascades in the spinal cord. Thermal hyperalgesia relies principally on activation of spinal NMDA receptors, translocation of protein kinase C, and production of nitric oxide and cGMP. In contrast, mechanical hyperalgesia relies principally on coactivation of spinal AMPA and metabotropic glutamate receptors, activation of phospholipase A<sub>2</sub> (PLA<sub>2</sub>), and production of cyclooxygenase products.</p></div>","PeriodicalId":100112,"journal":{"name":"APS Journal","volume":"3 4","pages":"Pages 215-231"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1058-9139(05)80269-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86173652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
APS JournalPub Date : 1994-09-01Epub Date: 2005-08-01DOI: 10.1016/S1058-9139(05)80318-3
Scott Haldeman
{"title":"In defense of the independent medical examiner","authors":"Scott Haldeman","doi":"10.1016/S1058-9139(05)80318-3","DOIUrl":"10.1016/S1058-9139(05)80318-3","url":null,"abstract":"","PeriodicalId":100112,"journal":{"name":"APS Journal","volume":"3 3","pages":"Pages 191-192"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1058-9139(05)80318-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84997605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
APS JournalPub Date : 1994-09-01Epub Date: 2005-08-01DOI: 10.1016/S1058-9139(05)80316-X
W.D. Willis Jr.
{"title":"The role of the spinothalamic tract in the plastic changes in somatosensory thalamus and cortex caused by inflammation","authors":"W.D. Willis Jr.","doi":"10.1016/S1058-9139(05)80316-X","DOIUrl":"10.1016/S1058-9139(05)80316-X","url":null,"abstract":"","PeriodicalId":100112,"journal":{"name":"APS Journal","volume":"3 3","pages":"Pages 183-186"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1058-9139(05)80316-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91532065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
APS JournalPub Date : 1994-09-01Epub Date: 2005-08-01DOI: 10.1016/S1058-9139(05)80322-5
Stanley L. Chapman
{"title":"Notes from membership","authors":"Stanley L. Chapman","doi":"10.1016/S1058-9139(05)80322-5","DOIUrl":"https://doi.org/10.1016/S1058-9139(05)80322-5","url":null,"abstract":"","PeriodicalId":100112,"journal":{"name":"APS Journal","volume":"3 3","pages":"Page 205"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1058-9139(05)80322-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138428375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
APS JournalPub Date : 1994-09-01Epub Date: 2005-08-01DOI: 10.1016/S1058-9139(05)80312-2
Peter R. Wilson
{"title":"Diskography is still investigational","authors":"Peter R. Wilson","doi":"10.1016/S1058-9139(05)80312-2","DOIUrl":"10.1016/S1058-9139(05)80312-2","url":null,"abstract":"","PeriodicalId":100112,"journal":{"name":"APS Journal","volume":"3 3","pages":"Pages 163-165"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1058-9139(05)80312-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76666718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
APS JournalPub Date : 1994-09-01Epub Date: 2005-08-01DOI: 10.1016/S1058-9139(05)80308-0
Nikolai Bogduk
{"title":"Diskography","authors":"Nikolai Bogduk","doi":"10.1016/S1058-9139(05)80308-0","DOIUrl":"https://doi.org/10.1016/S1058-9139(05)80308-0","url":null,"abstract":"<div><p>Lumbar diskography is not a test for disk herniation. It is a test for intrinsically painful, externally intact disks and so does not compete with computed tomography as a diagnostic instrument. Formal studies have shown that the lumbar disks are innervated and can be a source of pain that has pathomorphologic correlates. The biological basis for lumbar diskography, therefore, resists criticism. Cervical diskography, however, lacks the same biological basis and remains open to criticism. Utility is the weak point of both lumbar and cervical diskography. Although both provide diagnostic information, it remains to be shown that this information makes a difference to outcome when treatment is direct to the ostensibly painful disk.</p></div>","PeriodicalId":100112,"journal":{"name":"APS Journal","volume":"3 3","pages":"Pages 149-154"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1058-9139(05)80308-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138428359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}