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Editor's note 编者按
Antimicrobic Newsletter Pub Date : 1989-10-01 DOI: 10.1016/0738-1751(89)90020-8
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引用次数: 0
Penetration of antibiotics into the CSF and the treatment of meningitis: Personal commentary and review of selected agents— part 1 抗生素进入脑脊液和脑膜炎的治疗:个人评论和所选药物的回顾-第1部分
Antimicrobic Newsletter Pub Date : 1989-10-01 DOI: 10.1016/0738-1751(89)90021-X
Charles E. Cherubin
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引用次数: 0
Tissue and tissue fluid penetration of antibiotics 组织和组织液中抗生素的渗透
Antimicrobic Newsletter Pub Date : 1989-09-01 DOI: 10.1016/0738-1751(89)90026-9
Marc Lebel
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引用次数: 3
The development of resistance during antimicrobial therapy 抗菌素治疗期间耐药性的发展
Antimicrobic Newsletter Pub Date : 1989-09-01 DOI: 10.1016/0738-1751(89)90027-0
D. Amsterdam
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引用次数: 6
Interactions between microorganisms, antimicrobics, and cells 微生物、抗菌剂和细胞之间的相互作用
Antimicrobic Newsletter Pub Date : 1989-09-01 DOI: 10.1016/0738-1751(89)90028-2
Eugene A. Gorzynski
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引用次数: 3
Editor's note 编者按
Antimicrobic Newsletter Pub Date : 1989-09-01 DOI: 10.1016/0738-1751(89)90025-7
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引用次数: 0
Antimicrobial susceptibility testing of Haemophilus influenzae: An update 流感嗜血杆菌的抗微生物药敏试验:最新进展
Antimicrobic Newsletter Pub Date : 1989-08-01 DOI: 10.1016/0738-1751(89)90015-4
James H. Jorgensen
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引用次数: 1
Editor's note 编者按
Antimicrobic Newsletter Pub Date : 1989-08-01 DOI: 10.1016/0738-1751(89)90013-0
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引用次数: 0
Dual-action antibacterials: A concept newly realized for antibacterial chemotherapy 双作用抗菌药:抗菌化疗新实现的概念
Antimicrobic Newsletter Pub Date : 1989-08-01 DOI: 10.1016/0738-1751(89)90014-2
Roy Cleeland, Harry Albrecht, George Beskid, Kakong Chan, James Christenson, Nafsika Georgopapadakou, Dennis Keith, David Pruess, Edwina Squires, Chung Chen Wei, Manfred Weigele
{"title":"Dual-action antibacterials: A concept newly realized for antibacterial chemotherapy","authors":"Roy Cleeland,&nbsp;Harry Albrecht,&nbsp;George Beskid,&nbsp;Kakong Chan,&nbsp;James Christenson,&nbsp;Nafsika Georgopapadakou,&nbsp;Dennis Keith,&nbsp;David Pruess,&nbsp;Edwina Squires,&nbsp;Chung Chen Wei,&nbsp;Manfred Weigele","doi":"10.1016/0738-1751(89)90014-2","DOIUrl":"10.1016/0738-1751(89)90014-2","url":null,"abstract":"<div><p>Ro 23-9424 represents the culmination of an idea put forth by O'Callaghan et al<sup>4</sup> in 1976. They proposed that a cephalosporin could act as a carrier for a second antibacterial with the total molecule functioning as a single antibacterial until separated by opening of the ß-lactam ring by a ß-lactamase or, as we now know, the target penicillin-sensitive enzymes. It is important to note that in spite of the ester linkage, hydrolysis of Ro 23-9424 in animals to the components is minimal and the elimination kinetics are those of a single molecule with a pharmacokinetic profile of the cephalosporin component. The results of our preliminary toxicology studies in rats and dogs also suggest that this compound will have a safety profile similar to that of the cephalosporin component. This would allow parenteral administration of the quinolone component, fleroxacin, at a much higher dosage than is possible with the free quinolone.</p><p>Ro 23-9424 represents the first of a new class of antibacterials. The major constraint in designing new compounds within this class will only be the ingenuity of the pharmaceutical chemist.</p></div>","PeriodicalId":100101,"journal":{"name":"Antimicrobic Newsletter","volume":"6 8","pages":"Pages 61-65"},"PeriodicalIF":0.0,"publicationDate":"1989-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0738-1751(89)90014-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79484266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Critical assessment of the newer non-quinolone oral antimicrobial agents 新非喹诺酮类口服抗菌剂的关键评估
Antimicrobic Newsletter Pub Date : 1989-07-01 DOI: 10.1016/0738-1751(89)90019-1
Ronald N. Jones
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引用次数: 5
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