胃肠病学 Pub Date : 2019-01-25 DOI: 10.3969/J.ISSN.1008-7125.2019.01.003

Yutang Ren, Bo Jiang, Xinhai Lin

引用次数: 0

Levels and Significance of Serum Macrophage Polarization-related Cytokines in Patients with Inflammatory Bowel Disease 炎症性肠病患者血清巨噬细胞极化相关细胞因子水平及意义

Chinese Journal of Gastroenterology Pub Date : 2015-09-25 DOI: 10.3969/J.ISSN.1008-7125.2015.09.006

Xiao-Ying Meng, M. Ji, Yi Fang, Jiachuan Wu, Lu Chen, Lu Xia

{"title":"Levels and Significance of Serum Macrophage Polarization-related Cytokines in Patients with Inflammatory Bowel Disease","authors":"Xiao-Ying Meng, M. Ji, Yi Fang, Jiachuan Wu, Lu Chen, Lu Xia","doi":"10.3969/J.ISSN.1008-7125.2015.09.006","DOIUrl":"https://doi.org/10.3969/J.ISSN.1008-7125.2015.09.006","url":null,"abstract":"Background: Inflammatory bowel disease( IBD) is a group of chronic and non-specific intestinal inflammatory diseases of undetermined origin. Functional impairment of macrophages has been associated with the dysregulation of mucosal immunity in intestinal tract of patients with IBD. Aims: To investigate the correlation of serum levels of macrophage polarization-related cytokines with the development and disease activity of IBD. Methods: A total of 105 IBD patients admitted from May 2013 to May 2014 at Shanghai Ruijin Hospital were recruited,of them 65 were Crohn's disease( CD) and 40 were ulcerative colitis( UC). Twenty-four patients with colonic polyps were served as controls. Serum samples were obtained and the levels of interleukin-1beta( IL-1β),IL-6,IL-10,IL-13,interferon-gamma( IFN-γ) and inducible nitric oxide synthase( i NOS) were determined by ELISA method. Results: Serum levels of IL-1β,IL-6,IL-10,IL-13 and IFN-γ were significantly higher in CD group than in control group( P 0. 05),and serum levels of IL-10,IL-13 and IFN-γ were significantly higher in UC group than in control group( P 0. 05). Logistic regression analysis revealed that serum IL-13( OR = 1. 009,P = 0. 005) and i NOS( OR = 0. 982,P = 0. 013) were correlated with CD,while Spearman correlation coefficient demonstrated a link between serum IL-10 and disease activity of CD( rs=- 0. 432,P =0. 014). No correlations were observed between serum levels of these cytokines and development and disease activity of UC( P 0. 05). Conclusions: Serum levels of macrophage polarization-related cytokines increase to varying degrees in IBD patients,but these cytokines have no obvious correlations with IBD and its disease activity. Presumably,theses cytokines are only involved in but not the triggers in the development of IBD.","PeriodicalId":10003,"journal":{"name":"Chinese Journal of Gastroenterology","volume":"20 1","pages":"538-541"},"PeriodicalIF":0.0,"publicationDate":"2015-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70180009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of epidermal growth factor and its receptor in regulating proliferation of colon cancer stem cells 表皮生长因子及其受体在结肠癌干细胞增殖调控中的作用

Chinese Journal of Gastroenterology Pub Date : 2013-01-01 DOI: 10.3969/J.ISSN.1008-7125.2013.12.003

Yanjun Feng, Qian Liu, Yi Fang, R. Song, Yiye Wan, Jiansheng Liu, Haiwei Wang, Du Yanzhi, Ji Zhang, Lu Xia

引用次数: 0

Colonoscopy and histology in the diagnosis of inflammatory bowel disease 结肠镜和组织学在炎性肠病诊断中的应用

Chinese Journal of Gastroenterology Pub Date : 2012-12-01 DOI: 10.3969/J.ISSN.1008-7125.2012.12.008

B. Shen

引用次数: 0

Expressions and significance of estrogen receptor and adaptor protein p66Shc in colon cancer 雌激素受体及受体蛋白p66Shc在结肠癌中的表达及意义

Chinese Journal of Gastroenterology Pub Date : 2012-09-01 DOI: 10.3969/J.ISSN.1008-7125.2012.09.003

Li Zhang, Yue Tian, Peng Li, Yong-dong Wu, Shutian Zhang, M. Lin

{"title":"Expressions and significance of estrogen receptor and adaptor protein p66Shc in colon cancer","authors":"Li Zhang, Yue Tian, Peng Li, Yong-dong Wu, Shutian Zhang, M. Lin","doi":"10.3969/J.ISSN.1008-7125.2012.09.003","DOIUrl":"https://doi.org/10.3969/J.ISSN.1008-7125.2012.09.003","url":null,"abstract":"Background:Estrogen and estrogen receptor(ER) are considered to play important roles in the tumorigenesis and progression of colon cancer,however,the mechanism of ER in colon caner is still unclear.Adaptor protein p66Shc is upregulated by steroid hormones in hormone-sensitive cancer cells,which is correlated with the steroid hormone-stimulated cell proliferation.Aims:To investigate the expressions and significance of ER and p66Shc in colon cancer.Methods: Protein expressions of ER and p66Shc in 65 paraffin-embedded colon cancer tissue and the corresponding adjacent noncancerous tissue were detected by immunohistochemistry.Correlation of p66Shc protein expression with the clinicopathological characteristics of colon cancer was analyzed.Results;Expressions of ER and p66Shc protein were located in nucleus and cytoplasm,respectively.Positivity rates of both ER and p66Shc protein were significantly higher in colon cancer tissue than in adjacent non-cancerous tissue(ER:47.7%vs.0%,P 0.01;p66She:49.2%vs.0%,P 0.01).Moreover,positive correlation was found between ER and p66Shc protein expressions(r = 0.43,P 0.05 ). Expression of p66Shc protein had no correlation with gender,age,primary tumor location,tumor size,gross type,depth of tumor invasion,lymph node metastasis and AJCC stage,however,it was significantly correlated with histological grading of colon cancer(well differentiated;22.2%,moderately differentiated:47.7%,poorly differentiated;75.0%,P = 0.046).Conclusions;Colon cancer might be an estrogen-sensitive malignancy.Estrogen and ER might cooperate with p66Shc to play a role in the tumorigenesis and progression of colon cancer.","PeriodicalId":10003,"journal":{"name":"Chinese Journal of Gastroenterology","volume":"17 1","pages":"527-530"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70179901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress in Study of microRNA in Inflammatory Bowel Disease 炎症性肠病microRNA的研究进展

胃肠病学 Pub Date : 2011-01-01 DOI: 10.3969/J.ISSN.1008-7125.2011.05.013

Jihua Cheng, L. Xia

引用次数: 0

Diagnosis of pancreatic endocrine tumor 胰腺内分泌肿瘤的诊断

Chinese Journal of Gastroenterology Pub Date : 2010-12-01 DOI: 10.3969/J.ISSN.1008-7125.2010.08.001

Chengwei Tang, Zhi-yin Huang, Rui Liu

引用次数: 0

Effect of valsartan on expression of leptin in rats with liver fibrosis 缬沙坦对肝纤维化大鼠瘦素表达的影响

Chinese Journal of Gastroenterology Pub Date : 2009-01-01 DOI: 10.3969/J.ISSN.1008-7125.2009.09.009

L. Pan, B. Shen, D. Yang, D. Hu, Jianfei Huang, X. Meng

{"title":"Effect of valsartan on expression of leptin in rats with liver fibrosis","authors":"L. Pan, B. Shen, D. Yang, D. Hu, Jianfei Huang, X. Meng","doi":"10.3969/J.ISSN.1008-7125.2009.09.009","DOIUrl":"https://doi.org/10.3969/J.ISSN.1008-7125.2009.09.009","url":null,"abstract":"Background:Leptin may be involved in the formation and development of liver fibrosis.AngiotensinⅡtype 1 receptor(AT1R) antagonist can decrease the synthesis and secretion of leptin in adipose tissue in rats.Aims:To evaluate the effect of valsartan,an AT1R antagonist,on expression of leptin in rats with immunodamaged hepatic fibrosis.Methods: Thirty-six Sprague-Dawley rats were randomly divided into normal control group,model group and valsartan prevention group.In the latter two groups,liver fibrosis model was constructed by intraperitoneal injection with hog serum.Valsartan (30 mg/kg) was intragastrically administered daily after the construction of liver fibrosis in valsartan prevention group.At the 10th week,all the rats were sacrificed.The degree of fibrosis and collagen area were evaluated by HE and Sirius red staining.Expression of leptin was determined by immunohistochemistry staining.Results:As compared with normal control group,the degree of fibrosis(P0.05),collagen area(10.08%±2.01%vs.0.62%±0.31%,P0.01) and expression of liver tissue leptin(5.05±2.91 vs.0.44±0.27,P0.05) were obviously increased in model group.After intervention with valsartan,all the above-mentioned indices significantly ameliorated.Conclusions:Leptin can induce liver fibrosis,and AT1R antagonist valsartan can delay the development of liver fibrosis via the reduction of leptin expression in liver tissue, which may be one of the mechanisms of its anti-fibrosis effect.","PeriodicalId":10003,"journal":{"name":"Chinese Journal of Gastroenterology","volume":"14 1","pages":"547-550"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70179879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasonography in the diagnosis of gallstone ileus: Report of a case 超声诊断胆石性肠梗阻1例

Chinese Journal of Gastroenterology Pub Date : 1997-09-01 DOI: 10.6557/GJTB.199709_14(3).0006

K. Wu, S. Pan, Sheng‐Hsuan Chen, Jean‐Dean Liu, G. Lien, Chun-Chao Chang

引用次数: 0

Endoscopic diagnosis of hookworm disease: Report of two cases 钩虫病的内镜诊断:附2例报告

胃肠病学 Pub Date : 1996-09-01 DOI: 10.6557/GJTB.199609_13(3).0007

F. Suk, G. Lien, Sheng‐Hsuan Chen, W. Chung, S. Pan, Jean‐Dean Liu, Chun-Chao Chang, K. Wu, Chi-Tan Hu

引用次数: 0

胃肠病学最新文献