Cellular and Molecular Immunology最新文献

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MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination 表达全长病毒蛋白的mcmv疫苗载体在单次接种后提供长期的体液免疫保护

Cellular and Molecular Immunology Pub Date : 2021-06-03 DOI: 10.21203/RS.3.RS-566785/V1

Yeonsu Kim, Xiaoyan Zheng, K. Eschke, M. Chaudhry, F. Bertoglio, A. Tomic, Astrid Krmpotić, M. Hoffmann, Y. Bar-On, J. Boehme, D. Bruder, T. Ebensen, L. Brunotte, S. Ludwig, M. Messerle, Carlos Guzman, O. Mandelboim, Michael Hust, S. Pöhlmann, S. Jonjić, L. Čičin-Šain

{"title":"MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination","authors":"Yeonsu Kim, Xiaoyan Zheng, K. Eschke, M. Chaudhry, F. Bertoglio, A. Tomic, Astrid Krmpotić, M. Hoffmann, Y. Bar-On, J. Boehme, D. Bruder, T. Ebensen, L. Brunotte, S. Ludwig, M. Messerle, Carlos Guzman, O. Mandelboim, Michael Hust, S. Pöhlmann, S. Jonjić, L. Čičin-Šain","doi":"10.21203/RS.3.RS-566785/V1","DOIUrl":"https://doi.org/10.21203/RS.3.RS-566785/V1","url":null,"abstract":"Global pandemics caused by influenza or coronaviruses cause severe disruptions to public health and lead to high morbidity and mortality. There remains a medical need for vaccines against these pathogens. CMV (cytomegalovirus) is a β-herpesvirus that induces uniquely robust immune responses in which remarkably large populations of antigen-specific CD8 + T cells are maintained for a lifetime. Hence, CMV has been proposed and investigated as a novel vaccine vector for expressing antigenic peptides or proteins to elicit protective cellular immune responses against numerous pathogens. We generated two recombinant murine CMV (MCMV) vaccine vectors expressing hemagglutinin (HA) of influenza A virus (MCMV HA ) or the spike protein of severe acute respiratory syndrome coronavirus 2 (MCMV S ). A single injection of MCMVs expressing either viral protein induced potent neutralizing antibody responses, which strengthened over time. Importantly, MCMV HA -vaccinated mice were protected from illness following challenge with the influenza virus, and we excluded that this protection was due to the effects of memory T cells. Conclusively, we show here that MCMV vectors induce not only long-term cellular immunity but also humoral responses that provide long-term immune protection against clinically relevant respiratory pathogens.","PeriodicalId":9682,"journal":{"name":"Cellular and Molecular Immunology","volume":"67 1","pages":"234 - 244"},"PeriodicalIF":0.0,"publicationDate":"2021-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76230976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Effect of ebosin on modulating interleukin-1β-induced inflammatory responses in rat fibroblast-like synoviocytes 伊博素在大鼠成纤维细胞样滑膜细胞中调节白细胞介素-1β诱导的炎症反应的作用

Cellular and Molecular Immunology Pub Date : 2015-05-04 DOI: 10.1038/cmi2015.36

Yang Zhang, Li-fei Wang, Liping Bai, R. Jiang, Lian-hong Guo, Jian-bo Wu, G. Cheng, Ren Zhang, Yuan Li

引用次数: 9