Transplantation reviews (Orlando, Fla.)最新文献

RUNX1 in liver graft ischemia-reperfusion injury: a cell-specific framework for ex vivo intervention. RUNX1在肝移植缺血再灌注损伤中的作用：体外干预的细胞特异性框架。

Transplantation reviews (Orlando, Fla.) Pub Date : 2026-10-15 DOI: 10.1016/j.trre.2026.101063

Fu-Kun Xiang, Si-Qing Zhou, Li Yi, Yu-Ran Liu, Jia-Cen Li, Wen-Jie Su

{"title":"RUNX1 in liver graft ischemia-reperfusion injury: a cell-specific framework for ex vivo intervention.","authors":"Fu-Kun Xiang, Si-Qing Zhou, Li Yi, Yu-Ran Liu, Jia-Cen Li, Wen-Jie Su","doi":"10.1016/j.trre.2026.101063","DOIUrl":"https://doi.org/10.1016/j.trre.2026.101063","url":null,"abstract":"Hepatic ischemia-reperfusion injury (HIRI) remains a major obstacle to the use of marginal donor livers. RUNX1 has not yet been established as a causal regulator of acute HIRI, and several transcription factors have stronger disease-specific evidence. We therefore asked whether existing human transplant datasets could help define where a RUNX1 hypothesis is most plausible. In 80 paired pre- and post-reperfusion biopsies from 40 recipients (GSE151648), RUNX1 increased after reperfusion (log2 fold change 1.449; FDR 1.65e-28), although the between-group difference in within-patient change was not significant for the biopsy-defined IRI-positive and IRI-negative groups. In the single-transplant GSE171539 dataset, RUNX1-high myeloid cells increased from 10.5% before procurement and 10.1% at the end of preservation to 32.9% at 2 h after reperfusion, with the signal concentrated in inflammatory monocyte and Kupffer/macrophage-like states. These observations support prioritizing the myeloid compartment for direct testing but do not establish causality. We outline distinct working hypotheses for myeloid cells, liver sinusoidal endothelial cells (LSECs), and hepatocytes, and argue that transient pharmacological or targeted RNA perturbation is better suited to the acute reperfusion window than durable viral expression. Translation will require a staged path from causal models to discarded-human-liver perfusion and, ultimately, transplantation after ex vivo treatment.","PeriodicalId":94259,"journal":{"name":"Transplantation reviews (Orlando, Fla.)","volume":" ","pages":"101063"},"PeriodicalIF":0.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating HLA eplet analysis into contemporary histocompatibility practice: opportunities, challenges and a proposed clinical workflow. 将HLA等位基因分析纳入当代组织相容性实践：机遇、挑战和拟议的临床工作流程。

Transplantation reviews (Orlando, Fla.) Pub Date : 2026-10-14 DOI: 10.1016/j.trre.2026.101062

Ruth Fergie, Fotini Partheniou

引用次数: 0

Corrigendum to "Resilience and coping among living kidney donors: An overview of the literature" [Transplant. Rev. 40/4 (2026) 101057]. “活肾供者的恢复力和应对：文献综述”的更正[移植]。Rev. 40/4(2026) 101057]。

Transplantation reviews (Orlando, Fla.) Pub Date : 2026-10-09 DOI: 10.1016/j.trre.2026.101058

Mia Walker, Kathleen Gaudio, Alessia N Paparella, Shaifali Sandal

引用次数: 0

Corrigendum to "The short- and long-term outcomes in living-donor liver transplantation using small-for-size graft: A systematic review and meta-analysis" [Transplantation Reviews Volume 37/1 (2023) 100747]. “使用小尺寸移植物的活体供肝移植的短期和长期结果：系统回顾和荟萃分析”[移植评论卷37/1(2023)100747]的更正。

Transplantation reviews (Orlando, Fla.) Pub Date : 2026-07-27 DOI: 10.1016/j.trre.2026.101042

Sang Hoon Kim, Ki-Hun Kim, Hwui-Dong Cho

引用次数: 0

Palliative care for solid organ transplant candidates and recipients: A scoping review. 实体器官移植候选人和接受者的姑息治疗：范围综述。

Transplantation reviews (Orlando, Fla.) Pub Date : 2025-12-01 Epub Date: 2025-08-05 DOI: 10.1016/j.trre.2025.100957

Liesbet Van Bulck, Fiona Ecarnot, Mathilde Giffard

{"title":"Palliative care for solid organ transplant candidates and recipients: A scoping review.","authors":"Liesbet Van Bulck, Fiona Ecarnot, Mathilde Giffard","doi":"10.1016/j.trre.2025.100957","DOIUrl":"10.1016/j.trre.2025.100957","url":null,"abstract":"Background: Solid organ transplant patients experience high morbidity and mortality before and after transplantation. International guidelines recommend integrating palliative care into the management of patients with advanced organ failure, including transplant candidates and recipients, as it supports advance care planning, enhances communication and improves symptom management. However, it remains unknown how and to what extent palliative care is actually provided to these patients. The present scoping review aimed to systematically summarize and compare existing evidence regarding the integration of palliative care for solid organ transplant patients.Methods: We searched PubMed, Web of Science, Embase, Cochrane and ClinicalTrials.gov for original articles published regarding the provision of palliative care to adult candidates or recipients of heart, lung, kidney, or liver transplant and/or their caregivers. This scoping review is reported in accordance with the PRISMA-ScR guidance.Results: Thirty-two articles were included. Most studies were conducted in the United States, included lung or liver patients, and relied on small samples. Overall, between 2 % and 53 % of patients had at least one palliative care consultation, and between 0 % and 35 % had end-of-life care conversations. Symptom management, especially pain and dyspnea, was the most important reason for referral. Some studies demonstrated that early palliative care interventions improved symptom management and care planning.Conclusion: This scoping review shows that palliative care for organ transplant has received little attention heretofore. Further research is essential, especially for kidney and heart transplant patients, to determine optimal timing throughout the transplant journal, referral indications, and the effectiveness of palliative care interventions.","PeriodicalId":94259,"journal":{"name":"Transplantation reviews (Orlando, Fla.)","volume":"39 4","pages":"100957"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0