The ocular surface最新文献

{"title":"Interdisciplinary management of belantamab mafodotin-associated ocular toxicity in clinical practice.","authors":"Mattan Arazi, Aya Wattad, Hila Magen, Abraham Avigdor, Nirit Agay, Yoav Berger, Irina S Barequet","doi":"10.1016/j.jtos.2025.09.003","DOIUrl":"10.1016/j.jtos.2025.09.003","url":null,"abstract":"<p><strong>Purpose: </strong>Belantamab mafodotin (BLENREP), an antibody-drug conjugate for relapsed/refractory multiple myeloma (RRMM), is associated with corneal toxicity driven by limbal stem cell dysfunction and corneal epithelial damage. We examined how keratopathy severity relates to hematologic management decisions in clinical practice.</p><p><strong>Methods: </strong>Retrospective cohort at a tertiary referral center, including RRMM patients treated with belantamab mafodotin (2019-2022). Ophthalmic examinations were performed at baseline and before each cycle; keratopathy was graded using the Keratopathy and Visual Acuity (KVA) scale. The primary outcome was the association between KVA severity (modeled as a time-dependent covariate) and management (dose reduction, treatment holiday, or discontinuation). Secondary outcomes included predictors of severe KVA, impact of management on immediate KVA change, and timing of the first management change.</p><p><strong>Results: </strong>Among 41 patients (mean age 67.10 ± 11.78 years; 23/41 [56.1 %] female), 38/41 (92.68 %) developed KVA keratopathy. The median time to first KVA occurrence was 4.14 weeks, and to first management change was 7.29 weeks. Higher KVA grade was associated with earlier management change (HR 1.514; 95 % CI 1.048-2.187; p = 0.0270). At the first assessment after the initial intervention, KVA worsened after treatment holidays (+0.70 ± 0.114 grades) and improved after dose reductions (-0.20 ± 0.084; p = 0.0165). Overall, during follow-up, the most common intervention was a treatment holiday (23/37, 56.1 %), followed by dose reduction (16/37, 39.0 %) and discontinuation (6/37, 16.2 %).</p><p><strong>Conclusion: </strong>KVA keratopathy occurred more frequently than in clinical trials, and nearly all patients required treatment modification. Given the strong relationship between KVA severity and management decisions, close ophthalmic monitoring from Grade 1 is warranted to mitigate progression and reduce vision-related morbidity.</p>","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":"324-329"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter to the editor regarding \"Simple limbal epithelial transplantation versus cultivated limbal epithelial transplantation in ocular burns\".","authors":"Namrata Sharma, Renu Venugopal, Sujata Mohanty, Kamalakannan Priyadarshini, Ritu Nagpal, Deepali Singhal, Aafreen Bari, Tanuj Dada, Prafulla Kumar Maharana, Tushar Agarwal, Ashish Dutt Upadhyay","doi":"10.1016/j.jtos.2025.07.007","DOIUrl":"10.1016/j.jtos.2025.07.007","url":null,"abstract":"","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-based classification of fungal and Acanthamoeba keratitis using confocal microscopy.","authors":"Rohith Erukulla, Kosar Esmaili, Amir Rahdar, Mehdi Aminizade, Kasra Cheraqpour, Seyed Ali Tabatabaei, Zahra Bibak-Bejandi, Seyed Farzad Mohammadi, Siamak Yousefi, Mohammad Soleimani","doi":"10.1016/j.jtos.2025.07.012","DOIUrl":"10.1016/j.jtos.2025.07.012","url":null,"abstract":"<p><strong>Introduction: </strong>Fungal and Acanthamoeba keratitis carry the worst prognoses among microbial keratitis (IK), owing to challenges in diagnosis and treatment. This study assesses the feasibility of deep learning (DL) to classify types of IK-fungal keratitis (FK), Acanthamoeba keratitis (AK), and nonspecific keratitis (NSK) (any other corneal inflammation)-and subtyping of FK using in vivo confocal microscopy.</p><p><strong>Methods: </strong>In this study, we employed transfer learning with a ResNet50 architecture to classify culture-confirmed keratitis types in a dataset of 1975 images (1137 FK, 457 AK, and 381 NSK) obtained from the Heidelberg Retinal Tomograph 3 (HRT 3). The dataset was split into training and testing sets. Data augmentation (e.g., rotation, zooming) was applied to the training subset to address class imbalance, and class weighting was used (5x for AK, 30x for NSK). Both models were trained for 150 epochs using the Adam optimizer with 5-fold cross-validation. Model 1 performed multi-class classification (FK, AK, NSK). Model 2 classified FK cases as either filamentous or non-filamentous.</p><p><strong>Results: </strong>Model 1 achieved a macro average accuracy of 87 % and a weighted average accuracy of 89 %. Precision and recall were high for AK (93 %, 96 %) and FK (90 %, 92 %), while NSK showed lower performance (78 %, 71 %). Model 2 demonstrated an accuracy of 85 % in subtyping FK, with an F1-score of 0.81 for filamentous and 0.85 for non-filamentous, an ROC AUC of 0.94, and a PR AUC of 0.95.</p><p><strong>Conclusion: </strong>DL models can accurately classify IK and subtype FK, enhancing diagnostic accuracy and informing targeted treatment strategies.</p>","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":"203-208"},"PeriodicalIF":5.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tear lymphotoxin-alpha deficiency is associated with conjunctival epitheliopathy in patients with dry eye disease.","authors":"Yun Yang, Tong Lin, Lan Gong","doi":"10.1016/j.jtos.2025.07.009","DOIUrl":"10.1016/j.jtos.2025.07.009","url":null,"abstract":"","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":"209-218"},"PeriodicalIF":5.6,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective consecutive case series of patients with neurotrophic keratopathy associated with unilateral total limbal stem cell deficiency caused by severe ocular surface burns.","authors":"Gustavo S Figueiredo, Teodor Stefanache, Oliver J Baylis, Hardeep-Singh Mudhar, Majlinda Lako, Francisco C Figueiredo","doi":"10.1016/j.jtos.2025.07.002","DOIUrl":"10.1016/j.jtos.2025.07.002","url":null,"abstract":"<p><strong>Introduction: </strong>Limbal stem cell deficiency (LSCD) is commonly caused by ocular surface burns. Corneal nerve damage, often due to infection, inflammation, trauma, leads to neurotrophic keratopathy (NK). This study investigates corneal sensation and nerve damage in patients with unilateral total LSCD before and after autologous cultivated limbal epithelial transplantation (Auto-CLET).</p><p><strong>Methods: </strong>This prospective, single-centre case series included patients with unilateral total LSCD due to severe burns treated at Royal Victoria Infirmary, UK, between June 2012 and January 2018. Corneal sensation was assessed using Cochet-Bonnet aesthesiometry at baseline and 6 months post-Auto-CLET, and in vivo confocal microscopy (IVCM) was used to examine nerve regeneration.</p><p><strong>Results: </strong>Twenty-three patients (19 males, 4 females) received Auto-CLET. Successful restoration of the ocular surface was achieved in all patients, confirmed by slit lamp examination, impression cytology, and IVCM at follow-ups up to 36 months. Baseline best corrected visual acuity was 1.67 logMAR in the affected eye compared to a mean of -0.08 in the healthy eye. Corneal aesthesiometry in LSCD eyes averaged 9.13 mm at baseline, increasing to 12.0 mm at 6 months post-Auto-CLET, though this change was not statistically significant (p = 0.26). IVCM revealed no regeneration of corneal nerves at any follow-up intervals, indicating persistent nerve damage.</p><p><strong>Conclusions: </strong>Despite successful ocular surface restoration, corneal nerve damage persisted, leaving patients at risk of persistent NK. To address this, we strongly suggest continuous topical treatment with blood derived products, such as serum eye drops, but also newly developed therapies such as IGF and rhNGF class of drugs.</p>","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":"195-202"},"PeriodicalIF":5.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding \"Simple limbal epithelial transplantation versus cultivated limbal epithelial transplantation in ocular burns\".","authors":"Mehmet Gurdal, Ozlem Barut Selver","doi":"10.1016/j.jtos.2025.07.006","DOIUrl":"https://doi.org/10.1016/j.jtos.2025.07.006","url":null,"abstract":"","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Reply to Prof. Jacqueline Tan's letter. Efficacy of eyelid warming devices as a first-step treatment in meibomian gland dysfunction: A systematic review with meta-analysis. 2025; 37:33-46.","authors":"Ballesteros-Sánchez Antonio, Carlos Rocha-de-Lossada, José-María Sánchez-González","doi":"10.1016/j.jtos.2025.04.002","DOIUrl":"10.1016/j.jtos.2025.04.002","url":null,"abstract":"","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Significant errors in the paper by Ballesteros-Sánchez A, Rocha-de-Lossada C and Sánchez-González J. Efficacy of eyelid warming devices as first-step treatment in meibomian gland dysfunction: A systematic review with meta-analysis. 2025; 37:33–46","authors":"Jacqueline Tan","doi":"10.1016/j.jtos.2025.04.003","DOIUrl":"https://doi.org/10.1016/j.jtos.2025.04.003","url":null,"abstract":"","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AZR-MD-001 0.5% selenium sulfide ophthalmic ointment for the treatment of contact lens discomfort: A vehicle-controlled, randomized, clinical trial.","authors":"Fiona Stapleton, Mark Hinds, Jacqueline Tan, Lyndon Jones, Robin Chalmers, Charles Bosworth, Yair Alster","doi":"10.1016/j.jtos.2024.12.009","DOIUrl":"10.1016/j.jtos.2024.12.009","url":null,"abstract":"<p><strong>Background: </strong>Contact lens discomfort (CLD) is a common problem for CL wearers, and patients with CLD often have changes in meibomian gland function and structure. In a Phase 2 trial AZR-MD-001 0.5% (AZR) ophthalmic ointment improved meibomian gland dysfunction (MGD) in non-lens wearers. The current study evaluated the efficacy and safety of AZR in participants with CLD and concomitant MGD.</p><p><strong>Methods: </strong>Adults with CLD (Contact Lens Dry Eye Questionnaire-8 >12, range 0-37) and MGD (Meibomian Gland Secretion Score [MGS] ≤12, range 0-45) were randomized (1:1) to AZR:vehicle applied twice-weekly in a three-month multicenter, prospective, double-masked study. Endpoints included difference in change from baseline (CFB) in the number of Meibomian Glands Yielding Liquid Secretion (MGYLS), MGS, the ability to wear their lenses as long as desired, and safety.</p><p><strong>Results: </strong>At Month 3, AZR (n = 34) significantly increased the MGYLS and MGS versus vehicle (n = 33), with least squares mean difference (LSMD) CFB in MGYLS of 5.0 (SE = 0.47) for AZR and 1.6 (0.45) for vehicle, P < 0.0001; MGS of 13.8 (SE = 0.67) for AZR and 3.8 (SE = 0.68) for vehicle, P < 0.0001. Significantly more participants treated with AZR were able to wear lenses as long as desired (43% vs. 6%, P = 0.0023). The most common treatment-emergent adverse event (TEAE) was eye irritation (61.8% AZR; 0% vehicle). All TEAEs related to treatment were mild/moderate, transient, and did not result in discontinuation.</p><p><strong>Conclusion: </strong>AZR-MD-001 0.5% significantly improved MGD signs and hours of comfortable CL wear, demonstrating good efficacy, safety, and tolerability in those with CLD.</p>","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Readership awareness series – Paper 9: Retraction of a publication","authors":"Mohammad Javed Ali, Ali Djalilian","doi":"10.1016/j.jtos.2024.01.008","DOIUrl":"https://doi.org/10.1016/j.jtos.2024.01.008","url":null,"abstract":"Abstract not available","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139489297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}