The ocular surface最新文献

{"title":"Artificial Intelligence-based smartphone application for real-time blinking assessment.","authors":"Tammy H Osaki, Gustavo A Bonesso, Regina C Coelho, Carlos M G de Godoy, Lilian E Ohkawara, Barbara M R T Santos, Tulio R Eschiapati, Juliana Y Washiya, Midori H Osaki","doi":"10.1016/j.jtos.2026.05.002","DOIUrl":"https://doi.org/10.1016/j.jtos.2026.05.002","url":null,"abstract":"","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective evaluation of patient reported outcome measures (PROMs) and correlation with clinical parameters of chronic ocular graft-versus-host disease (GVHD).","authors":"Jonas Milek, Olaf Penack, Igor-Wolfgang Blau, Robert Roehle, Anna-Karina B Maier, Tina Dietrich-Ntoukas","doi":"10.1016/j.jtos.2026.05.004","DOIUrl":"https://doi.org/10.1016/j.jtos.2026.05.004","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate different patient reported outcome measures (PROMs) and their relationship with distinct clinical parameters in patients with and without chronic ocular graft-versus-host disease (coGVHD) after allogeneic hematopoietic stem cell transplantation.</p><p><strong>Methods: </strong>In this prospective cross-sectional study, 68 patients after alloHSCT were included and allocated in two groups: with coGVHD and without coGVHD (n=34 each). Clinical ophthalmological parameters were assessed and the following PROMs were used: Ocular Surface Disease Index (OSDI), National Eye Institute Visual Function Questionnaire (NEI-VFQ-25), Syndrome Assessment in Dry Eye Questionnaire (SANDE), Generalized Anxiety Disorder Scale 7 (GAD-7). Statistical analysis was performed by using group adjusted correlation and multiple linear regression.</p><p><strong>Results: </strong>Patients with coGVHD had worse scores compared to patients without coGVHD. PROMs were highly correlated with each other. Diagnosis of coGVHD was a highly influential predictor for impairment in quality of life. No correlations between PROM scores and single clinical parameters were found.</p><p><strong>Conclusion: </strong>This study confirms the importance of PROMs in patients with coGVHD. Quality of life (QOL) is clearly impaired in affected individuals compared to patients after alloHSCT without coGVHD. The entirety of all clinical features is the major influencing factor of QOL impairment whereas single parameters alone seem to have no measurable effect. SANDE showed comparable results to OSDI and is explicitly recommended in clinical routine.</p>","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic Profiling of Tear Fluid in Patients with Atopic Keratoconjunctivitis.","authors":"Lars Iversen, Manuel Ramirez Garrastacho, Pernille May Hansen, Bernd Thiede, Jacob Pontoppidan Thyssen, Marie Louise Roed Rasmussen, Oliver Niels Klefter, Steffen Heegaard, Tor Paaske Utheim","doi":"10.1016/j.jtos.2026.05.005","DOIUrl":"https://doi.org/10.1016/j.jtos.2026.05.005","url":null,"abstract":"<p><strong>Purpose: </strong>Atopic keratoconjunctivitis (AKC) is a chronic, severe ocular surface disease associated with atopic dermatitis, which may impair vision and ultimately lead to blindness. In this study, discovery-based proteomic analysis was performed on tear samples from patients with AKC to elucidate molecular characteristics and identify proteins of interest.</p><p><strong>Methods: </strong>All patients underwent thorough ophthalmological examination and were divided into four subgroups: healthy controls (n = 17), atopic dermatitis without ocular surface disease (n = 11), mild (n = 65), and moderate-severe AKC (n = 32). Tear film samples collected with Schirmer's filtration paper were analyzed with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Proteins were considered significantly regulated if they demonstrated a p-value lower than 0.05, following correction for multiple hypothesis testing, and if they exhibited a fold change greater than 2.</p><p><strong>Results: </strong>A total of 2503 proteins were identified. Compared with controls, mild AKC and moderate-severe AKC showed 14 and 29 significantly regulated proteins, respectively. Mild vs moderate-severe AKC yielded 21 significantly regulated proteins. Four proteins overlapped in both mild AKC and moderate-severe AKC compared to healthy controls: Short-chain specific acyl-CoA dehydrogenase, serpin B13, non-secretory ribonuclease, and probable E3 ubiquitin-protein ligase HERC4. Regulated proteins were involved in immune-related, metabolic, and epithelial processes.</p><p><strong>Conclusion: </strong>This exploratory proteomic study suggests that AKC is associated with changes in immune-related pathways, including mucosal innate immunity, eosinophil migration, and cytokine signaling, as well as metabolic processes, and epithelial differentiation and barrier function.</p>","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Video-Derived Focus Stacking Enhances Depth of Field in Ocular Anterior Segment Imaging.","authors":"Christoph Palme, Paolo Bonatti, Alexander Franchi, Nadja Franz, Barnabas Kremser, Victoria Stöckl, Bernhard Steger","doi":"10.1016/j.jtos.2026.05.006","DOIUrl":"https://doi.org/10.1016/j.jtos.2026.05.006","url":null,"abstract":"","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: 'Pard3 promotes corneal epithelial stratification and homeostasis by regulating apical-basal polarity, cytoskeletal organization and tight junction-mediated barrier function' Journal: 'The Ocular Surface' Volume 37, July 2025, Pages 201-215.","authors":"Mehak Vohra, Simran Kumar, Peri Sohnen, Satinder Kaur, Sudha Swamynathan, Tomonori Hirose, Zbynek Kozmik, Shivalingappa K Swamynathan","doi":"10.1016/j.jtos.2026.04.010","DOIUrl":"https://doi.org/10.1016/j.jtos.2026.04.010","url":null,"abstract":"","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Mechanoreceptor Piezo1 channel-mediated interleukin expression in conjunctival epithelial cells: Linking mechanical stress to ocular inflammation\" [Ocul. Surf. 36 (2025) 56-68].","authors":"Seiya Fukuoka, Naoki Adachi, Erika Ouchi, Hideshi Ikemoto, Takayuki Okumo, Fumihiro Ishikawa, Hidetoshi Onda, Masataka Sunagawa","doi":"10.1016/j.jtos.2026.05.001","DOIUrl":"https://doi.org/10.1016/j.jtos.2026.05.001","url":null,"abstract":"","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Hybrid System Integrating Deep Learning and Computer Vision for Automated Blink Monitoring and Tear Film Break-Up Pattern Classification.","authors":"Yike Li, An-Peng Pan, Yiting Sun, Xiuming Jin, A-Yong Yu","doi":"10.1016/j.jtos.2026.04.011","DOIUrl":"https://doi.org/10.1016/j.jtos.2026.04.011","url":null,"abstract":"<p><strong>Purpose: </strong>To construct and validate a hybrid system integrating deep learning and computer vision for real-time blink monitoring, tear film Break-Up Patterns (BUPs) classification, and Dry Eye (DE) subtype diagnosis and treatment recommendation.</p><p><strong>Methods: </strong>This prospective study included 95 subjects. Three YOLOv8 models (YOLOv8-n/s/m) were trained and compared to detect ocular structures and Tear Film Break Up (TFBU) regions. The best-performing model was integrated with OpenCV image processing algorithms based on geometric morphology to classify five specific BUPs (Area, Line, Spot, Dimple, and Random) and perform real-time blink monitoring. The overall performance of the automated system was validated on an independent test set.</p><p><strong>Results: </strong>Significant differences in Ocular Surface Disease Index (OSDI) and Tear-film Break Up Time (TBUT) were observed between the DE (n=65) and non-DE (n=30) groups (P < 0.001). The YOLOv8-m model was selected for its optimal performance (Precision: 74.6% for TFBU detection) to construct the automated blink monitoring and BUPs classification system. In the test set, this system achieved a 100% success rate in blink monitoring and an overall BUPs classification accuracy of 75.47%. System-measured TBUT (STBUT) and Manually-measured TBUT (MTBUT) demonstrated excellent agreement. Notably, STBUT (1.99±1.36 s) was significantly shorter than MTBUT (2.21±1.47 s, P<0.01), reflecting the system's higher sensitivity in detecting early TFBU, alongside inherent methodological differences. Bland-Altman analysis confirmed that differences were predominantly distributed within the 95% limits of agreement.</p><p><strong>Conclusion: </strong>The hybrid system enables real-time blink monitoring and precise BUPs classification, supporting Tear Film-Oriented Diagnosis (TFOD) and personalized DE management.</p>","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147825380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifitegrast ophthalmic solution 5.0% (KH732) for dry eye disease: A randomized, multicenter, double-masked, vehicle-controlled phase 3 trial.","authors":"Yang Lu, Xiuming Jin, Xiaofeng Li, Ying Jie, Liming Tao, Shengwei Ren, Shaozhen Zhao, Ying Li, Guoxing Xu, Wenjuan Zhuang, Ying Li, Wei Chen, Shanjun Cai, Hao Gu, Hong Zhang, Lan Li, Zhipeng You, Jianqiao Li, Jiangyue Zhao, Qi Chen, Ting Huang, Pengcheng Wu, Ting Wang, Yong Yao, Hua Wang, Zhuo Li, Xiangwen Shu, Ruifeng Wang, Mingchang Zhang, Feng Wen, Yao Fu, Cheng Pei, Wei Zhang, Huaijin Guan, Hui Zhao, Jizhong Yang, Lin Song, Min He, Xingxiang Lv, Fusheng Wu, Lan Gong, Xinghuai Sun","doi":"10.1016/j.jtos.2026.04.006","DOIUrl":"10.1016/j.jtos.2026.04.006","url":null,"abstract":"<p><strong>Background: </strong>Dry eye disease (DED) commonly impairs quality of life. This phase 3, randomized, double-masked, multicenter, vehicle-controlled trial evaluated the efficacy of 5.0% lifitegrast ophthalmic solution (KH732) in improving signs and symptoms of DED.</p><p><strong>Methods: </strong>Adults with moderate-to-severe DED and corneal staining score ≥2.0 in any corneal region were randomized 1:1 to lifitegrast (KH732) or vehicle twice daily for 84 days after a 3-7-day vehicle washout. The primary endpoint was change from baseline in inferior corneal staining score (ICSS) at Day 84. Secondary endpoints included changes in total corneal staining score, Eye Dryness Score (EDS), Ocular Surface Disease Index (OSDI), 7-item visual analogue scale, and Ocular Discomfort Score.</p><p><strong>Results: </strong>At Day 84, lifitegrast (n = 309) significantly reduced ICSS versus vehicle (n = 306) (P = 0.027). In a post hoc analysis, the effect was more pronounced in participants with the highest baseline staining in the inferior region (P = 0.046). Lifitegrast also significantly improved EDS (adjusted P = 0.006), ocular discomfort (adjusted P = 0.010), photophobia (adjusted P = 0.004), and OSDI (adjusted P = 0.014) versus vehicle. Post hoc analyses showed significant between-group differences in EDS, photophobia, and OSDI as early as Day 14. No serious ocular adverse events were reported.</p><p><strong>Conclusions: </strong>Lifitegrast (KH732) improved both signs and symptoms of DED and was generally well tolerated, with potentially greater benefit in patients with prominent inferior corneal staining.</p>","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":"45-53"},"PeriodicalIF":5.6,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147825387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transmigrated Neutrophils on the Ocular Surface and in Other Tissues: A Narrative Review.","authors":"Yutong Jin, Sadaf Mohsenkhani, Maria Walker, Lyndon Jones, Maud Gorbet","doi":"10.1016/j.jtos.2026.04.007","DOIUrl":"https://doi.org/10.1016/j.jtos.2026.04.007","url":null,"abstract":"<p><p>Neutrophils (polymorphonuclear neutrophils, PMNs) represent 60% of the total leukocytes in the blood, playing an essential role in innate immune defence. PMNs were originally considered to be homogenous, but a growing body of evidence suggests that they exhibit considerable heterogeneity and express various phenotypes in different tissue types under physiological and pathological conditions. This review provides an overview of the PMNs phenotypes found in various human tissues, including the lungs, female reproductive tract, mouth, and eyes, under both physiological and pathological conditions. PMNs collected from the ocular surface after prolonged eye closure, termed 'tear PMNs', represent an emerging area of research in ocular immunology and inflammation. Their potential origin, diurnal-nocturnal pattern and functions, and their role in ocular complications are also presented and discussed.</p>","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pipeline: Design of therapeutic trials in Ocular Surface Disease.","authors":"Gary D Novack","doi":"10.1016/j.jtos.2026.03.004","DOIUrl":"10.1016/j.jtos.2026.03.004","url":null,"abstract":"","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147535281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}