The ocular surface最新文献

Prospective consecutive case series of patients with neurotrophic keratopathy associated with unilateral total limbal stem cell deficiency caused by severe ocular surface burns. 严重眼表烧伤引起的神经营养性角膜病变伴单侧全角膜缘干细胞缺乏的前瞻性连续病例系列。

IF 5.6

The ocular surface Pub Date : 2025-07-25 DOI: 10.1016/j.jtos.2025.07.002

Gustavo S Figueiredo, Teodor Stefanache, Oliver J Baylis, Hardeep-Singh Mudhar, Majlinda Lako, Francisco C Figueiredo

{"title":"Prospective consecutive case series of patients with neurotrophic keratopathy associated with unilateral total limbal stem cell deficiency caused by severe ocular surface burns.","authors":"Gustavo S Figueiredo, Teodor Stefanache, Oliver J Baylis, Hardeep-Singh Mudhar, Majlinda Lako, Francisco C Figueiredo","doi":"10.1016/j.jtos.2025.07.002","DOIUrl":"https://doi.org/10.1016/j.jtos.2025.07.002","url":null,"abstract":"Introduction: Limbal stem cell deficiency (LSCD) is commonly caused by ocular surface burns. Corneal nerve damage, often due to infection, inflammation, trauma, leads to neurotrophic keratopathy (NK). This study investigates corneal sensation and nerve damage in patients with unilateral total LSCD before and after autologous cultivated limbal epithelial transplantation (Auto-CLET).Methods: This prospective, single-centre case series included patients with unilateral total LSCD due to severe burns treated at Royal Victoria Infirmary, UK, between June 2012 and January 2018. Corneal sensation was assessed using Cochet-Bonnet aesthesiometry at baseline and 6 months post-Auto-CLET, and in vivo confocal microscopy (IVCM) was used to examine nerve regeneration.Results: Twenty-three patients (19 males, 4 females) received Auto-CLET. Successful restoration of the ocular surface was achieved in all patients, confirmed by slit lamp examination, impression cytology, and IVCM at follow-ups up to 36 months. Baseline best corrected visual acuity was 1.67 logMAR in the affected eye compared to a mean of -0.08 in the healthy eye. Corneal aesthesiometry in LSCD eyes averaged 9.13 mm at baseline, increasing to 12.0 mm at 6 months post-Auto-CLET, though this change was not statistically significant (p = 0.26). IVCM revealed no regeneration of corneal nerves at any follow-up intervals, indicating persistent nerve damage.Conclusions: Despite successful ocular surface restoration, corneal nerve damage persisted, leaving patients at risk of persistent NK. To address this, we strongly suggest continuous topical treatment with blood derived products, such as serum eye drops, but also newly developed therapies such as IGF and rhNGF class of drugs.","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor regarding "Simple limbal epithelial transplantation versus cultivated limbal epithelial transplantation in ocular burns". 致编辑关于“单纯角膜缘上皮移植与培养角膜缘上皮移植治疗眼部烧伤”的信。

The ocular surface Pub Date : 2025-07-23 DOI: 10.1016/j.jtos.2025.07.006

Mehmet Gurdal, Ozlem Barut Selver

引用次数: 0

Re: Reply to Prof. Jacqueline Tan's letter. Efficacy of eyelid warming devices as a first-step treatment in meibomian gland dysfunction: A systematic review with meta-analysis. 2025; 37:33-46. 眼睑温热装置作为睑板腺功能障碍第一步治疗的疗效：一项系统综述和meta分析。

The ocular surface Pub Date : 2025-04-17 DOI: 10.1016/j.jtos.2025.04.002

Ballesteros-Sánchez Antonio, Carlos Rocha-de-Lossada, José-María Sánchez-González

引用次数: 0

Re: Significant errors in the paper by Ballesteros-Sánchez A, Rocha-de-Lossada C and Sánchez-González J. Efficacy of eyelid warming devices as first-step treatment in meibomian gland dysfunction: A systematic review with meta-analysis. 2025; 37:33–46 回复：Ballesteros-Sánchez A、Rocha-de-Lossada C和Sánchez-González j的论文存在显著错误。眼睑温热装置作为睑板腺功能障碍第一步治疗的疗效：一项meta分析的系统综述。2025年;37:33-46

The ocular surface Pub Date : 2025-04-11 DOI: 10.1016/j.jtos.2025.04.003

Jacqueline Tan

引用次数: 0

AZR-MD-001 0.5% selenium sulfide ophthalmic ointment for the treatment of contact lens discomfort: A vehicle-controlled, randomized, clinical trial. AZR-MD-001 0.5%硫化硒眼膏治疗隐形眼镜不适：一项对照、随机、临床试验。

The ocular surface Pub Date : 2024-12-28 DOI: 10.1016/j.jtos.2024.12.009

Fiona Stapleton, Mark Hinds, Jacqueline Tan, Lyndon Jones, Robin Chalmers, Charles Bosworth, Yair Alster

{"title":"AZR-MD-001 0.5% selenium sulfide ophthalmic ointment for the treatment of contact lens discomfort: A vehicle-controlled, randomized, clinical trial.","authors":"Fiona Stapleton, Mark Hinds, Jacqueline Tan, Lyndon Jones, Robin Chalmers, Charles Bosworth, Yair Alster","doi":"10.1016/j.jtos.2024.12.009","DOIUrl":"10.1016/j.jtos.2024.12.009","url":null,"abstract":"Background: Contact lens discomfort (CLD) is a common problem for CL wearers, and patients with CLD often have changes in meibomian gland function and structure. In a Phase 2 trial AZR-MD-001 0.5% (AZR) ophthalmic ointment improved meibomian gland dysfunction (MGD) in non-lens wearers. The current study evaluated the efficacy and safety of AZR in participants with CLD and concomitant MGD.Methods: Adults with CLD (Contact Lens Dry Eye Questionnaire-8 >12, range 0-37) and MGD (Meibomian Gland Secretion Score [MGS] ≤12, range 0-45) were randomized (1:1) to AZR:vehicle applied twice-weekly in a three-month multicenter, prospective, double-masked study. Endpoints included difference in change from baseline (CFB) in the number of Meibomian Glands Yielding Liquid Secretion (MGYLS), MGS, the ability to wear their lenses as long as desired, and safety.Results: At Month 3, AZR (n = 34) significantly increased the MGYLS and MGS versus vehicle (n = 33), with least squares mean difference (LSMD) CFB in MGYLS of 5.0 (SE = 0.47) for AZR and 1.6 (0.45) for vehicle, P < 0.0001; MGS of 13.8 (SE = 0.67) for AZR and 3.8 (SE = 0.68) for vehicle, P < 0.0001. Significantly more participants treated with AZR were able to wear lenses as long as desired (43% vs. 6%, P = 0.0023). The most common treatment-emergent adverse event (TEAE) was eye irritation (61.8% AZR; 0% vehicle). All TEAEs related to treatment were mild/moderate, transient, and did not result in discontinuation.Conclusion: AZR-MD-001 0.5% significantly improved MGD signs and hours of comfortable CL wear, demonstrating good efficacy, safety, and tolerability in those with CLD.","PeriodicalId":94247,"journal":{"name":"The ocular surface","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Readership awareness series – Paper 9: Retraction of a publication 读者意识系列 - 文件 9：撤回出版物

The ocular surface Pub Date : 2024-01-17 DOI: 10.1016/j.jtos.2024.01.008

Mohammad Javed Ali, Ali Djalilian

引用次数: 0