Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)最新文献

{"title":"Efficacy of ascorbic acid coated quantum dots in alleviating lead-induced oxidative damage and enhancing growth parameters in rice (Oryza sativa L.) for sustainable cultivation.","authors":"Aliza Falak, Muhammad Anas, Amjid Khan, Alvina Hayat, Zeenat Shaheen, Muhammad Hamzah Saleem, Shah Fahad, Umar Masood Quraishi","doi":"10.1016/j.jtemb.2025.127603","DOIUrl":"https://doi.org/10.1016/j.jtemb.2025.127603","url":null,"abstract":"<p><p>Lead (Pb) toxicity impairs the growth, yield, and biochemical traits of rice, making it essential to mitigate Pb stress in soil and restore its growth and production. This study investigated the potential of ascorbic acid-coated quantum dots (AsA-QDs) in alleviating Pb stress in two rice cultivars, Japonica (JP-5) and Indica (Super Basmati), grown in pots under Pb stress (50 mg/kg as lead chloride) with AsA-QD suspensions (50 ppm and 100 ppm) as treatments. The synthesized AsA-QDs were characterized by zeta potential (-14.4 mV), particle size (472.3 nm, PDI 0.745), UV-Vis absorption peak (240 nm), FT-IR analysis revealing functional groups (carboxylic acid and alkene), and TEM showing spherical morphology (average size 9.43 nm). Pb stress reduced key traits in JP-5, including tillers per plant (11.11 %), grain yield (18.22 %), kernel weight (18.22 %), protein (40.19 %), phenolic content (59.66 %), and antioxidant capacity (17.75 %), while 50 ppm AsA-QDs improved these by 33.33 %, 5.73 %, 2.03 %, and 13.19 %, respectively. Similarly, Pb stress reduced plant height, T/P, biomass yield (BY), GY, TKW, total sugars, reducing sugars, non-reducing sugars, starch, proteins, and TPC in Super Basmati by 19.76 %, 21.43 %, 11.01 %, 11.01 %, 7.52 %, 38.09 %, 7.24 %, 13.96 %, 11.97 %, and 40.39 %, respectively, while PbQD1 improved these traits by 14.29 %, 15.49 %, 9.25 %, 109.52 %, 8.31 %, 31.72 %, 25.91 %, and 7.075 %, respectively. The findings demonstrate that AsA-QDs effectively mitigate Pb toxicity by reducing oxidative stress, enhancing growth parameters, and restoring yield components, establishing them as a promising nanomaterial for sustainable crop resilience under Pb stress.</p>","PeriodicalId":94118,"journal":{"name":"Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)","volume":"88 ","pages":"127603"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iodine intakes of pregnant females from Québec, Canada.","authors":"Jesse Bertinato, Philip Griffin, Cunye Qiao, Deborah Cavalcanti, Louise Ghesquière, Emmanuel Bujold","doi":"10.1016/j.jtemb.2025.127601","DOIUrl":"https://doi.org/10.1016/j.jtemb.2025.127601","url":null,"abstract":"<p><strong>Background: </strong>Adequate maternal iodine intake is important for fetal brain development. Based on iodine intakes of non-pregnant females of reproductive age from the Canadian Health Measures Survey (2016 -2017) it can be extrapolated that most pregnant females in Canada will not meet iodine requirements without supplementation.</p><p><strong>Objectives: </strong>To assess iodine intakes of 500 pregnant, nulliparous females from Québec, Canada and report on use of multivitamin/mineral (MVM) supplements and coverage of iodized salt.</p><p><strong>Methods: </strong>Duplicate spot urine samples were collected at 10.1 -14.9 weeks (T1) and 19.7 -24.9 weeks (T2) of gestation. Median urinary iodine concentrations (UIC) were compared with WHO/UNICEF/ICCIDD reference ranges. Daily iodine intakes were calculated from UIC using a formula that corrects for urine dilution using creatinine and accounts for urinary iodine excretion rate. Usual (adjusted for within-person variation) iodine intakes were estimated from duplicate daily intake measurements (T1 and T2 measures) using the National Cancer Institute method. Prevalence of inadequate or excessive intakes were determined from usual intakes by the Estimated Average Requirement (EAR) or Tolerable Upper Intake Level (UL) cut-point method, respectively.</p><p><strong>Results: </strong>Females (median: 30.1 years) were mostly white race (94.4 %), highly educated and consumed iodized salt (92 %). Median UIC at T1 (136 µg/L, IQR: 71 -230) was lower (p<0.001) than at T2 (193 µg/L, IQR: 112 -390). Almost all females used a MVM supplement (98.2 %) with 35.6 % starting supplementation preconception and 0.6 %, 28.4 %, 19.8 %, 7.2 % and 6.0 % starting 1 -2 weeks, 3 -4 weeks, 5 -8 weeks, 8 -12 weeks and > 12 weeks postconception, respectively. Almost all (99 %, 95 % CI: 98, 100) had usual iodine intakes ≥EAR and ≤UL.</p><p><strong>Conclusions: </strong>Prevalence of inadequate or excessive usual iodine intakes was low. However, about two-thirds of females started MVM supplementation postconception and median UIC at T1 was below the adequate range of 150 -249 µg/L.</p>","PeriodicalId":94118,"journal":{"name":"Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)","volume":"88 ","pages":"127601"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute arsenic exposure induces cyto-genotoxicity and histological alterations in Labeo rohita.","authors":"Fakhira Khalid, Hamda Azmat","doi":"10.1016/j.jtemb.2025.127600","DOIUrl":"https://doi.org/10.1016/j.jtemb.2025.127600","url":null,"abstract":"<p><strong>Background: </strong>Arsenic emerges as most potent hazardous element ranked as number one in ATSDR (Agency for Toxic Substances and Disease Registry) list, can easily accumulate in fish, transported to humans via consumption and affect humans and aquatic organisms. Considering above, current experiment designed to evaluate cyto-genotoxicity and histological alterations induced by arsenic in Labeo rohita used as an animal model.</p><p><strong>Methods: </strong>By applying complete randomized design sampling acclimatized individuals of Labeo rohita (10 batches of 10 each with triplicates) were exposed to nine definitive doses (12, 14, 16, 18, 20, 22, 24, 26 and 28 mgL^-1) of arsenic in glass aquaria to determine 96-h lethal concentration (LC₅₀) of arsenic. Control group without arsenic was also run simultaneously. After 96-h exposure various histo-biochemical parameters were evaluated in all experimental groups.</p><p><strong>Results: </strong>The 96-h lethal concentration of arsenic was found to be 20.2 mgL^-1. Upon arsenic exposure, oxidative stress biomakers: catalase (CAT), superoxide dismutase (SOD) and lipid per oxidation (LPO) and accumulation of arsenic in all targeted organs were considerably (p ≤ 0.05) increased in dose dependent manner and in comparison, to unexposed (control) group. Serum liver function enzymes, immunological status (albumin, globulin and total protein), cortisol level and cytochrome P450 gene expression remarkably (p ≤ 0.05) altered on arsenic exposure. The histological analysis also showed destructive alterations on exposure to arsenic in gill and liver tissues.</p><p><strong>Conclusion: </strong>These results confirmed that exposure of arsenic led to pronounced deleterious alterations in Labeo rohita and evidencing the need for monitoring alarmingly increasing concentration of arsenic.</p>","PeriodicalId":94118,"journal":{"name":"Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)","volume":"88 ","pages":"127600"},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the magnesium depletion score and all-cause and cardiovascular mortality among asthma patients: A Study based on the NHANES population from 2005-2018.","authors":"Lanxin Fan, Xueqing Gong, Hongling Jia","doi":"10.1016/j.jtemb.2025.127602","DOIUrl":"https://doi.org/10.1016/j.jtemb.2025.127602","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the potential association between magnesium depletion score (MDS), a novel assessment of magnesium status in vivo, and all-cause and cardiovascular mortality in asthma patients.</p><p><strong>Methods: </strong>Using data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018, 4757 asthmatics were included in the study and were categorized into four groups based on their MDS levels (MDS=0, MDS=1, MDS=2, and MDS≥3). Survival differences between the different MDS groups were analysed using Kaplan-Meier curves, and weighted multivariate Cox regression models assessed the relationship between MDS and mortality. In addition, non-linear relationships between MDS and all-cause and cardiovascular mortality were explored using restricted cubic spline (RCS) regression models, and subgroup analyses were performed to validate the results.</p><p><strong>Results: </strong>Kaplan-Meier curves showed that both all-cause and cardiovascular mortality were significantly higher in the group with higher levels of MDS (P < 0.001). After controlling for all confounders, asthmatics in the higher MDS group faced a higher risk of death compared with the lower MDS group, as evidenced by a 3.29-fold increase in all-cause mortality (95 % CI: 2.05, 5.29) and a 4.68-fold increase in cardiovascular mortality (95 % CI: 1.77, 12.35). Fully adjusted Cox regression models further confirmed the significant positive association of high MDS with the risk of all-cause and cardiovascular mortality.RCS plots revealed a linear dose-response relationship between MDS and mortality. In the subgroup analyses, no interaction factors other than cardiovascular disease were found to significantly influence the relationship between MDS and mortality.</p><p><strong>Conclusion: </strong>Higher levels of MDS independently predicted the risk of mortality, especially cardiovascular mortality, in US adults with asthma. Therefore, the MDS may become a cost-effective and widely applicable prognostic assessment tool for asthma, providing an important reference for clinical decision-making and patient management.</p>","PeriodicalId":94118,"journal":{"name":"Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)","volume":"88 ","pages":"127602"},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium ameliorates cognitive impairment through activating BDNF/TrkB pathway.","authors":"Yu Liu, Ye Liu, Liping Shi, Xue Zhang, Kunmei Liu, Shulan He","doi":"10.1016/j.jtemb.2025.127599","DOIUrl":"https://doi.org/10.1016/j.jtemb.2025.127599","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is a neurodegenerative disorder that primarily affects older adults. Selenium, an essential micronutrient for humans, plays a crucial role in the body's normal physiological and metabolic processes. A long-term deficiency in selenium intake can lead to various diseases and even contribute to the ageing process. This study aims to explore the ameliorative effect of selenium on cognitive impairment in 3 × Tg-AD mice and to determine if its effects are related to the BDNF/TrkB pathway.</p><p><strong>Methods: </strong>We employed the APP/PS1/tau 3 × Tg-AD mouse model for dietary selenium intervention. Behavioural experiments were conducted to assess learning and memory. Additionally, we measured selenium and GSH-Px levels in whole blood and brain tissue. Neuronal apoptosis in the hippocampus was observed using transmission electron microscopy. The expressions of Aβ, P-tau, BDNF, TrkB, and CREB were measured via RT-qPCR, while the expressions of Aβ, P-tau, BDNF, TrkB, p-CREB, and CREB were quantified using Western blot analysis.</p><p><strong>Results: </strong>Our findings indicate that selenium supplementation can improve spatial learning and memory deficiencies in 3 × Tg-AD mice. Selenium supplementation increased selenium and GSH-Px levels in the brain tissue of 3 × Tg-AD mice and significantly enhanced neuronal conditions. Furthermore, the expression levels of proteins related to the BDNF/TrkB pathway significantly increased following selenium supplementation.</p><p><strong>Conclusions: </strong>Our study demonstrates that selenium can ameliorate memory impairment in 3 × Tg-AD mice by activating the BDNF/TrkB pathway.</p>","PeriodicalId":94118,"journal":{"name":"Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)","volume":"88 ","pages":"127599"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of mercury exposure on male reproduction: Mechanistic insights.","authors":"Bhawna Kushawaha, Rajkumar Yadav, Satish Kumar Garg, Emanuele Pelosi","doi":"10.1016/j.jtemb.2025.127598","DOIUrl":"https://doi.org/10.1016/j.jtemb.2025.127598","url":null,"abstract":"<p><p>Mercury is a pervasive environmental toxin with significant negative effects on human health. In occupational settings, incidents such as the Minamata and Niigata disease in Japan and the large-scale methylmercury poisoning in Iraq have highlighted the severe health impacts of mercury exposure. It is widely accepted that all forms of mercury including methylmercury and mercuric chloride have the potential to induce toxic effects in mammals, and there is increasing concern about the impact of environmentally relevant levels of mercury on reproductive functions. This review summarizes current knowledge on the mechanisms of mercury toxicity, focusing specifically on its impact on male reproductive health across species. We searched the literature and found that mercury exposure is associated with testicular degeneration, altered spermatogenesis, and Leydig cell deformation. In addition, mercury can disrupt sperm motility, steroidogenesis and interfere with the hypothalamic-pituitary-gonadal axis by generation of reactive oxygen species, inducing mitochondrial dysfunction, epigenetic changes, and DNA damage. At the molecular level, mercury has been found to dysregulate the expression of key steroidogenic and spermatogenic genes, significantly reducing overall fertility potential. However, specific mechanisms of action remain to be fully elucidated. Similarly, comprehensive data on the potential transgenerational effects of paternal mercury exposure are lacking. In this review, we discuss both animal and human studies, and highlight the need for further research due to lack of standardization and control for variables such as lifestyle, immune system function, and exposure concentrations.</p>","PeriodicalId":94118,"journal":{"name":"Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)","volume":"87 ","pages":"127598"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of blood selenium with dyslipidemia in children and adolescents: a cross-sectional analysis.","authors":"Feiqi Lin, Zhiyuan Chen","doi":"10.1016/j.jtemb.2025.127596","DOIUrl":"https://doi.org/10.1016/j.jtemb.2025.127596","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to examine the association between blood selenium levels and dyslipidemia in children and adolescents.</p><p><strong>Methods: </strong>Data from the National Health and Nutrition Examination Survey (NHANES) 2011-2020 were analyzed, including 8191 participants aged 6-19 years. Dyslipidemia was defined by elevated total cholesterol (TC ≥ 200 mg/dL), lowered high-density lipoprotein cholesterol (HDL-C < 40 mg/dL), or elevated non-HDL-C (≥ 145 mg/dL). Associations between blood selenium levels and dyslipidemia were examined using multivariate logistic regression, linear regression, and restricted cubic spline (RCS) analysis.</p><p><strong>Results: </strong>The study population had a mean age of 12.33 years, with 51.21 % boys. After adjusting for multiple confounding factors, including dietary selenium intakes and supplementation, higher blood selenium levels were associated with increased odds of dyslipidemia and its components. In the highest quartile of blood selenium (>193.99 μg/L), adjusted odds ratios (ORs) were 1.60 (95 % confidence interval [CI]: 1.23-2.08) for dyslipidemia, 1.70 (95 % CI: 1.19-2.43) for elevated TC, 1.38 (95 % CI: 0.97-1.96) for lowered HDL-C, and 1.73 (95 % CI: 1.20-2.48) for elevated non-HDL-C. A significant nonlinear association was observed, with dyslipidemia prevalence increasing notably above a threshold of 184.28 μg/L (P-nonlinearity=0.02), following a J-shaped curve. Subgroup analysis revealed significant interaction by race (P-interaction=0.02), with non-Hispanic White individuals showing a stronger association (OR=1.83, 95 % CI: 1.19-2.80) compared to other racial groups (OR=1.40, 95 % CI: 1.05-1.88).</p><p><strong>Conclusion: </strong>Elevated blood selenium levels are associated with higher prevalence of dyslipidemia in children and adolescents, particularly among non-Hispanic White individuals. The association is nonlinear, with a notable increase in the prevalence of dyslipidemia observed above a blood selenium level of 184.28 μg/L. These findings suggest a need for further research to understand selenium's role in lipid profiles and its implications for public health.</p>","PeriodicalId":94118,"journal":{"name":"Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)","volume":"87 ","pages":"127596"},"PeriodicalIF":0.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish as environmental sentinels for metal contaminants of human health concern in the Lower Mississippi River Basin.","authors":"Scoty Hearst, Trent Selby, Joseph Kazery, Steven Everman, Manliang Feng, Lillian Sisson, Chinaza Nwaiwu, Alison Cevallos, James Lock, Matthew Sinclair","doi":"10.1016/j.jtemb.2025.127593","DOIUrl":"https://doi.org/10.1016/j.jtemb.2025.127593","url":null,"abstract":"<p><p>Industrial expansion and population growth have lowered water quality, polluting aquatic ecosystems world-wide. Metal pollution in the rivers across the United States are a major health concern. The level of metal contamination in fish from the Lower Mississippi River Basin and their threat to public health were last evaluated 20 years ago. The goals of this study were to measure metal contamination in various fish species from the Lower Mississippi River Basin, evaluate the human consumption risk, and estimate bioindicator potential of these species for monitoring toxic metals on a larger scale. Various fish species (n = 203) were analyzed for 15 metal contaminants (Al, As, Ba, Cd, Co, Cr, Cu, Fe, Hg, Mg, Mn, Ni, Pb, Se, and Zn). Species included: blue catfish (Ictalurus furcatus), channel catfish (Ictalurus punctatus), flathead catfish (Pylodictis olivaris), bigmouth buffalo (Ictiobus cyprinellus), smallmouth buffalo (Ictiobus bubalus), alligator gar (Atractosteus spatula), spotted gar (Lepisosteus oculatus), American gizzard shad (Dorosoma cepedianum), freshwater drum, (Aplodinotus grunniens), and white crappie (Pomoxis annularis). Fish consumption safety revealed toxic metals (As, Cd, Cr, Hg, and Pb) are a major human health concern in the Lower Mississippi River. Non-cancerous health hazard assessments indicated blue catfish, flathead catfish, gar species, and freshwater drum as species of concern. Consumption of all species posed human cancer risks. Computational modeling, with an accuracy of 98.5 %, identified Hg, Pb, Zn, Cr, Co, As, and Cd as major drivers of fish consumption safety. Using bioaccumulation factor analysis, we estimated the bioindicator potential of toxic metals for each fish species, finding Hg and Cd to be greatly bioaccumulative in predatory gar species. Overall, our data indicated that gar can serve as select environmental sentinels useful for monitoring toxic metal pollutants of public health concerns providing valuable insight to research scientist and monitoring agencies throughout the Lower Mississippi River Basin.</p>","PeriodicalId":94118,"journal":{"name":"Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)","volume":"87 ","pages":"127593"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between maternal serum zinc and birth weight is modified by neonatal SOD2 polymorphism and promoter methylation.","authors":"Yuting Zeng, Yalong Wang, Yanan He, Qinyang Li, Ruiqin Chen, Cuiping Wu, Na Li, Xinya Cheng, Yuhui Du, Fangfang Yu, Yue Ba, Guoyu Zhou","doi":"10.1016/j.jtemb.2025.127595","DOIUrl":"https://doi.org/10.1016/j.jtemb.2025.127595","url":null,"abstract":"<p><strong>Background: </strong>Conflicting findings exist regarding the association between maternal serum zinc and neonatal birth weight. This study aimed to explore the association between maternal serum zinc and birth weight, and whether this association was modified by neonatal SOD2 polymorphism and promoter methylation.</p><p><strong>Methods: </strong>We recruited 464 mother-newborn pairs at Houzhai Center Hospital from January 2010 to January 2012. Maternal serum zinc concentration was determined using atomic absorption spectrophotometry. Neonatal SOD2 polymorphism and promoter methylation were measured by TaqMan probe assay and real-time quantitative methylation-specific PCR (QMSP), respectively. Relationships among maternal serum zinc, neonatal SOD2 promoter methylation, and birth weight were analyzed by generalized linear model (GLM). Stratified and interaction analyses were conducted to explore the modification of neonatal SOD2 polymorphism and promoter methylation on the association between maternal serum zinc and birth weight.</p><p><strong>Results: </strong>Our findings revealed that higher maternal zinc concentrations were associated with decreased birth weight (P-trend < 0.05). Each 1 μmol/L increment in maternal zinc level was associated with a 9.553 g (95 % CI: -16.370, -2.735) decrease in birth weight. A significant interaction between SOD2 promoter methylation and maternal serum zinc in relation to birth weight was observed in the AG+GG group (P-interaction < 0.05). Newborns carrying AA genotype were more sensitive to maternal serum zinc in the lower SOD2 group (P-interaction < 0.05).</p><p><strong>Conclusions: </strong>Maternal serum zinc was inversely associated with birth weight, and this association was modified by neonatal SOD2 polymorphism and promoter methylation. These findings suggest that SOD2 polymorphism and promoter methylation may influence the relationship between maternal zinc status and fetal growth.</p>","PeriodicalId":94118,"journal":{"name":"Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)","volume":"87 ","pages":"127595"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of boron-containing compounds in biological systems: Potential applications and key challenges.","authors":"Haseeb Khaliq","doi":"10.1016/j.jtemb.2025.127594","DOIUrl":"https://doi.org/10.1016/j.jtemb.2025.127594","url":null,"abstract":"<p><strong>Background: </strong>Boron, a naturally abundant trace element, plays a crucial role in various biological processes and influences important physiological functions such as bone health, immune response, and cellular metabolism. Its applications span diverse scientific fields including anatomy, pharmacology, reproduction, medicine, and agriculture.</p><p><strong>Objectives: </strong>This review examines the diverse functions of boron-compounds in biological systems and highlights their therapeutic potential, challenges associated with toxicity, and mechanisms underlying their biological interactions.</p><p><strong>Methods: </strong>In this paper, the literature on boron action was reviewed, paying special attention to studies that examined the effects of boron on health and its therapeutic applications in multiple areas.</p><p><strong>Results: </strong>Boron exhibits broad therapeutic potential by affecting several pathways. However, excessive consumption can cause toxicity and negatively impact health. Current research only partially elucidates the mechanisms of boron's biological effects, so further studies are needed.</p><p><strong>Conclusion: </strong>Understanding boron's interactions in biological systems is critical to optimizing its application in healthcare and ensuring safety. Future research will improve our knowledge of boron's biological effects and promote innovative therapeutic applications.</p>","PeriodicalId":94118,"journal":{"name":"Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)","volume":"87 ","pages":"127594"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}