International journal of hygiene and environmental health最新文献

{"title":"Exposure to conventional and non-phthalate plasticizers in representative Korean population between 2010 and 2018: Sex and age-stratified comparisons.","authors":"Joeun Jung, Jin-Yeong Heo, Na-Youn Park, Younglim Kho, Kyungho Choi","doi":"10.1016/j.ijheh.2025.114679","DOIUrl":"https://doi.org/10.1016/j.ijheh.2025.114679","url":null,"abstract":"<p><p>Due to the adverse health effects reported for several phthalate plasticizers, many phthalates have been increasingly replaced with alternatives in various consumer applications. In this study, we employed urine samples collected from the nationally representative populations of 2010 (n = 785) and 2018 (n = 799) and measured metabolites (n = 37) of major phthalate and non-phthalate plasticizers. Exposure levels of phthalates and non-phthalate plasticizers were compared, and their associated risks were assessed. Over the period, on average, urinary metabolite concentrations of major phthalates like DEHP and DBP decreased by 26 % and 31 %, respectively. In contrast, urinary metabolites of DEHTP and DEHA increased by 2131 % and 33 %, respectively. Metabolite profiles varied by age group, with DEHTP showing the highest levels among infants and children. Urinary metabolite concentrations of conventional phthalates showed the least reduction, and those of non-phthalate plasticizers exhibited the greatest increases during this period. Despite regulatory efforts against the use of several phthalates, the estimated daily intake (EDI) for all plasticizers has doubled among infants and children during this period, with DEHA being identified as a major contributor. Overall risk estimated based on anti-androgenicity decreased between 2010 and 2018, but DEHP and DBP remained significant risk drivers despite regulations during this period. Further research on exposure sources is warranted to inform measures that reduce exposure to plasticizers among the vulnerable populations identified in the present study.</p>","PeriodicalId":94049,"journal":{"name":"International journal of hygiene and environmental health","volume":"270 ","pages":"114679"},"PeriodicalIF":0.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cumulative dietary pesticide exposure score based on produce consumption is associated with urinary pesticide biomarkers in a U.S. biomonitoring cohort.","authors":"Alexis M Temkin, Varun Subramaniam, Alexa Friedman, Elvira Fleury, Dayna de Montagnac, Chris Campbell, David Q Andrews, Olga V Naidenko","doi":"10.1016/j.ijheh.2025.114654","DOIUrl":"https://doi.org/10.1016/j.ijheh.2025.114654","url":null,"abstract":"<p><p>Pesticide exposure has been linked to chronic health harms, yet the effects of cumulative dietary exposure to pesticide mixtures are poorly understood. A pesticide load index was created to rank produce based on pesticide contamination from national pesticide residue testing data for 44 produce types, primarily collected from 2013 to 2018. Three indices were created utilizing different indicators of pesticide contamination and toxicity. Dietary pesticide exposure scores for 1837 individuals were calculated based on produce consumption from the 2015-2016 National Health and Nutrition Examination Survey (NHANES). Covariate-adjusted weighted linear regressions were used to estimate the change in average pesticide biomarker rank relative to dietary pesticide exposure scores. Pesticide load indices were calculated based on detections of 178 unique parent pesticides, or 42 parent pesticides with matched urinary biomarkers in NHANES. Increasing dietary pesticide exposure scores were not associated with average pesticide biomarker rank (β [95 % CI] = 0.02 [-0.34, 0.38]) and were consistent across scores that utilized the different indices. Matching pesticides in food and urine, results in a slightly stronger association (β [95 % CI] = 0.09 [-0.32, 0.51]). Excluding potatoes resulted in a positive significant association (β [95 % CI] = 0.75 [0.35, 1.14]). When excluding potatoes, consumption of fruits and vegetables weighted by pesticide contamination was associated with higher levels of urinary pesticide biomarkers for organophosphate, pyrethroid, and neonicotinoid insecticides. Future research could use this methodology, with the recommendation to exclude potatoes, to assess the impact of dietary pesticide exposure on health outcomes.</p>","PeriodicalId":94049,"journal":{"name":"International journal of hygiene and environmental health","volume":" ","pages":"114654"},"PeriodicalIF":0.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Exposure to endocrine disrupting chemicals including phthalates, phenols, and parabens in infancy: Associations with neurodevelopmental outcomes in the MARBLES study\" [IJHEH 261 (2024) 114425].","authors":"Jennie Sotelo-Orozco, Antonia M Calafat, Julianne Cook Botelho, Rebecca J Schmidt, Irva Hertz-Picciotto, Deborah H Bennett","doi":"10.1016/j.ijheh.2025.114590","DOIUrl":"https://doi.org/10.1016/j.ijheh.2025.114590","url":null,"abstract":"","PeriodicalId":94049,"journal":{"name":"International journal of hygiene and environmental health","volume":" ","pages":"114590"},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure characteristics of legacy PFAS, and their precursors and alternatives among children and adolescents of Korea.","authors":"Heeyeon Chae, Ju Yeon Choi, Hyeri Jeon, Won-Young Kim, Na-Youn Park, Inae Lee, Hyo-Bang Moon, Youglim Kho, Kyungho Choi","doi":"10.1016/j.ijheh.2025.114644","DOIUrl":"10.1016/j.ijheh.2025.114644","url":null,"abstract":"<p><p>Among children and adolescents, exposure to per- and poly-fluoroalkyl substances (PFAS) and their substitutes remains poorly characterized. This study analyzed major PFAS and their substitutes in serum samples from 257 children (6-12 years) and 283 adolescents (13-18 years) using the Korea Ministry of Food and Drug Safety biospecimen archive. Eleven compounds, including PFHpA, PFOA, PFNA, PFOS, and 9Cl-PF3ONS, were detected in over 70 % of the participants, with several legacy PFAS detected at levels exceeding those reported elsewhere. Among the study population, PFOA, PFHxS, and PFOS exhibited the highest concentrations, and children generally showed higher levels than adolescents. Notably, 85 % and 4 % of participants showed PFOA levels that exceeded HBM-1 and HBM-2 values, respectively. Among the substitutes, 9Cl-PF3ONS was detected in all participants, while 6:2FTS, a precursor, was present in more than half of the participating subjects (>55 %). PFAS levels, particularly those of PFOA and PFOS, were significantly higher among individuals consuming tap water compared to those relying on bottled water (p < 0.05). This likely reflects the higher contamination levels of surface water, the primary source for tap water, compared to groundwater, which is commonly used for bottled water in South Korea. Additionally, dietary intake, particularly seafood and meat consumption, was associated with elevated PFAS levels. The present findings highlight the high and widespread exposure to PFAS among Korean youth, emphasizing the need for further research to identify exposure sources and implement mitigation strategies to reduce PFAS exposure.</p>","PeriodicalId":94049,"journal":{"name":"International journal of hygiene and environmental health","volume":"269 ","pages":"114644"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal pyrethroid exposure, placental gene network modules, and neonatal neurobehavior.","authors":"Yewei Wang, Jacqueline Holstein, Karen Hermetz, Amber Burt, Corina Lesseur, Parinya Panuwet, Nancy Fiedler, Tippawan Prapamontol, Panrapee Suttiwan, Pimjuta Nimmapirat, Supattra Sittiwang, Warangkana Naksen, Volha Yakimavets, Dana Boyd Barr, Ke Hao, Jia Chen, Carmen J Marsit","doi":"10.1016/j.ijheh.2025.114646","DOIUrl":"10.1016/j.ijheh.2025.114646","url":null,"abstract":"<p><p>Prenatal pesticide exposure may adversely affect child neurodevelopment which may partly arise from impairing the placenta's vital role in fetal development. In a cohort of pregnant farmworkers from Thailand (N = 248), we examined the links between urinary metabolites of pyrethroid pesticides during pregnancy, placental gene expression networks derived from transcriptome sequencing, and newborn neurobehavior assessed using the NICU Network Neurobehavioral Scales (NNNS) at 5 weeks of age. Focusing on the 21 gene network modules in the placenta identified by Weighted Gene Co-expression Network Analysis, our analysis revealed significant associations between metabolites and nine distinct modules, and between thirteen modules and NNNS, with eight modules showing overlap. Notably, stress was negatively associated with the interferon alpha response and Myc target modules, and the interferon alpha response module was correlated positively with attention, and negatively with arousal, and quality of movement. The analysis also highlighted the early and late trimesters as critical periods for the exposures influence on placental function, with pyrethroid metabolites measured early in pregnancy significantly negatively associated with the protein secretion module, and those measured later in pregnancy negatively associated with modules related to oxidative phosphorylation (OXPHOS) and DNA repair. Additionally, the cumulative sum of 3-phenoxybenzoic acid across pregnancy was significantly negatively associated with the OXPHOS module. These findings suggest that prenatal exposure to pyrethroids may influence neonatal neurobehavior through specific placental mechanisms that impact gene expression of metabolic pathways, and these effects may be pregnancy period specific. These results offer valuable insights for future risk assessment and intervention strategies.</p>","PeriodicalId":94049,"journal":{"name":"International journal of hygiene and environmental health","volume":"269 ","pages":"114646"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal analysis of maternal exposure to phthalates and bisphenol A and their impact on infant neurodevelopment and autistic behavior: The potential mediating role of thyroid hormones.","authors":"Iman Al-Saleh, Yara Aljerayed, Mais Gheith, Norah Alobaid, Haneen Alenazi, Rola Elkhatib, Hesham Aldhalaan, Maha Alnemer, Gamal Mohamed, Mohamed Shoukri","doi":"10.1016/j.ijheh.2025.114647","DOIUrl":"10.1016/j.ijheh.2025.114647","url":null,"abstract":"<p><p>This prospective cohort study investigated the impact of maternal exposure to endocrine-disrupting chemicals, specifically phthalates and bisphenol A (BPA), on infant neurodevelopment. From 2019 to 2022, 672 pregnant women consented to participate in the study during their initial prenatal appointments at the Obstetrics and Gynecology Clinic of King Faisal Specialist Hospital & Research Centre. Two urine samples were collected each trimester to measure seven phthalate metabolites and BPA levels. Neurodevelopmental performance was evaluated using the Ages & Stages Questionnaires® Third Edition at 6, 12, and 18 months of age, and the risk of autism was assessed with the Modified Checklist For Autism in Toddlers at 18 months. Linear mixed models and logistic regression were applied to evaluate trimester-specific and overall associations using natural log-transformed urinary concentrations of phthalates and BPA. Our results showed that each one-unit increase in the log-transformed concentration of specific phthalates and BPA was associated with significant changes in infant developmental scores. During the first trimester, elevated levels of mono-n-butyl phthalate (MnBP), mono-iso-butyl phthalate (MiBP), and BPA were associated with 4.3 %-5.6 % decreases in gross motor (GM) scores. In contrast, monoethyl phthalate (MEP) and low-molecular-weight (∑LMW) phthalates were linked to 4 %-4.5 % increases in communication (COMM) scores. In the third trimester, MECPP and Σ₃DEHP were positively associated with GM and fine motor (FM) scores, while MiBP was associated with reduced personal-social (PSoc) scores. Sex-stratified analyses revealed differences in susceptibility, with males showing stronger adverse associations in problem-solving and social domains and females more affected in gross and fine motor scores. Mediation analysis identified free thyroxine (FT4) as a partial mediator, accounting for 12.7 % of the effect of ∑LMW phthalates on COMM scores during the first trimester. However, most mediation effects through maternal thyroid hormones were small and not statistically significant. Additionally, some first-trimester exposures, such as MEP and mono-(2-ethyl-5-oxohexyl) phthalate, appeared to be associated with lower odds of a positive M-CHAT screen. At the same time, MnBP showed a potential increase in risk. However, these exploratory findings were based on crude models and a limited number of positive cases and should be interpreted cautiously. Our study also examined overall exposure to phthalates and BPA across pregnancy, revealing consistent yet subtle impacts across developmental domains. This study adds novel insights by assessing trimester-specific exposures and investigating maternal thyroid hormones as potential mediators of early neurodevelopmental outcomes.</p>","PeriodicalId":94049,"journal":{"name":"International journal of hygiene and environmental health","volume":"269 ","pages":"114647"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}