Exploratory research and hypothesis in medicine最新文献

Reporting Quality of Trend Analyses Published in Leading Medicine and Oncology Journals during 2008-2018. 2008-2018年在主要医学和肿瘤学期刊上发表的趋势分析报告质量。

Exploratory research and hypothesis in medicine Pub Date : 2025-10-01 Epub Date: 2025-10-21 DOI: 10.14218/erhm.2025.00039

Xiaoling Yuan, Fei Deng, Yating Wang, Lanjing Zhang

{"title":"Reporting Quality of Trend Analyses Published in Leading Medicine and Oncology Journals during 2008-2018.","authors":"Xiaoling Yuan, Fei Deng, Yating Wang, Lanjing Zhang","doi":"10.14218/erhm.2025.00039","DOIUrl":"10.14218/erhm.2025.00039","url":null,"abstract":"Reporting quality in clinical research is critical for evidence-based medicine and reproducibility of clinical studies. Previous work has mostly focused on the reporting quality of clinical trials and observational longitudinal studies. However, few studies have examined the reporting quality of trend analyses. Moreover, the reporting of recommended statistical metrics in trend analyses remains largely unclear. Therefore, we assessed the reporting quality of trend analyses based on reporting of recommended statistical metrics. We systematically searched the PubMed for the trend-analysis articles published in 10 leading medicine and oncology journals over an 11-year period (2008-2018). Studies published after 2019 were excluded due to a sudden, significant increase in publication numbers during and immediately after the COVID-19 pandemic. Only original articles, research letters, and meta-analyses/systematic reviews were included. We scored the reporting quality of these articles based on whether they reported p-values, effect sizes, beta/coefficient/slope/annual-percentage-change (APC). 297 articles met the inclusion criteria. Among these, 193 (66.0%) reported p-values and 216 (72.7%) reported effect sizes. Only 13 (5.8%) analyses reported neither p-values/effect sizes nor beta/coefficient/slope/APC. In multivariable regression models, authors affiliated with epidemiology departments were less likely to report effect sizes, whereas those from statistics departments were more likely to do so. Interestingly, U.S.-based senior authors (versus non-U.S.) more likely reported p-values. No factors were independently associated with reporting APC. Overall, the reporting quality of trend analyses in leading medicine and oncology journals appears moderate and warrants improvement. We thus call for increased awareness and further research on reporting quality in trend analyses in oncology research and beyond.","PeriodicalId":94008,"journal":{"name":"Exploratory research and hypothesis in medicine","volume":"10 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12826571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

E64FC26, a Protein Disulfide Isomerase Inhibitor, Ameliorates Articular Cartilage Damage and Disease Severity in a Mouse Model of Rheumatoid Arthritis 蛋白二硫异构酶抑制剂E64FC26改善类风湿关节炎小鼠模型的关节软骨损伤和疾病严重程度

Exploratory research and hypothesis in medicine Pub Date : 2025-01-26 DOI: 10.14218/erhm.2024.00033

Haiyan Zhao, Ting Wang, Luna Ge, Yuang Zhang, Ruojia Zhang, Guanhua Song, Jihong Pan, Lin Wang, Jinxiang Han

引用次数: 1

Role of ELK3 in Ferroptosis of Rheumatoid Arthritis Fibroblast-like Synoviocytes ELK3在类风湿关节炎成纤维细胞样滑膜细胞铁下垂中的作用

Exploratory research and hypothesis in medicine Pub Date : 2025-01-20 DOI: 10.14218/erhm.2024.00036

Yaqun Zhang, Huimin Shi, Lin Wang, Jihong Pan

引用次数: 0

Expanding Role of Epigenetics in Human Health and Disease 表观遗传学在人类健康和疾病中的作用不断扩大

Exploratory research and hypothesis in medicine Pub Date : 2024-01-11 DOI: 10.14218/erhm.2023.00086

Swarup K. Chakrabarti, Dhrubajyoti Chattopadhyay

引用次数: 0

Neutrophil Elastase as a Predictor of Delivery in Pregnant Women with Preterm Labour 中性粒细胞弹性酶作为早产孕妇分娩的预测因子

Exploratory research and hypothesis in medicine Pub Date : 2023-10-27 DOI: 10.14218/erhm.2023.00032

George Uchenna Eleje, Uchenna Ifeanyi Nwagha, Ifeanyichukwu Uzoma Ezebialu, Emmanuel Onyebuchi Ugwu, Kingsley Emeka Ekwuazi, Joseph Ifeanyichukwu Ikechebelu, Euzebus Chinonye Ezugwu, Ahizechukwu Chigoziem Eke

引用次数: 0

Trypanocidal Treatment in Chronic Chagas Disease: Critical Evaluation of Cure Criteria 慢性恰加斯病的锥虫治疗:治愈标准的关键评价

Exploratory research and hypothesis in medicine Pub Date : 2023-10-26 DOI: 10.14218/erhm.2023.00057

Alejandro Marcel Hasslocher-Moreno, Gilberto Marcelo Sperandio-da-Silva, Roberto Magalhães Saraiva

引用次数: 0

Takotsubo Cardiomyopathy in Aneurysmal Subarachnoid Hemorrhage with an Atypical Clinical Presentation: A Case Report 动脉瘤性蛛网膜下腔出血并发Takotsubo心肌病，临床表现不典型1例

Exploratory research and hypothesis in medicine Pub Date : 2023-10-19 DOI: 10.14218/erhm.2023.00045

Isobel Han Ying Griffith, Faisal Usman Qureshi, Revin Thomas

{"title":"Takotsubo Cardiomyopathy in Aneurysmal Subarachnoid Hemorrhage with an Atypical Clinical Presentation: A Case Report","authors":"Isobel Han Ying Griffith, Faisal Usman Qureshi, Revin Thomas","doi":"10.14218/erhm.2023.00045","DOIUrl":"https://doi.org/10.14218/erhm.2023.00045","url":null,"abstract":"Takotsubo cardiomyopathy can masquerade as an acute coronary syndrome and present clinically with chest pain and dyspnea, electrocardiogram changes of cardiac ischemia and elevation of cardiac enzymes. Such changes are particularly relevant in cases where Takotsubo cardiomyopathy is associated with subarachnoid hemorrhage, and treatment of acute coronary syndrome with antiplatelet drugs is contraindicated. We describe a case of a 68-year-old woman, who developed ventricular changes consistent with Takotsubo cardiomyopathy following an aneurysmal subarachnoid hemorrhage. The patient presented with collapse and vomiting, initial workup revealed anterior ST-elevation electrocardiogram changes, increased troponin I, and a chest radiograph suggestive of acute cardiac failure. In light of this, the patient was managed initially as an acute coronary syndrome with antiplatelet medication. An echocardiogram showed acute left ventricular systolic dysfunction with apical ballooning. After 3 days of hospitalization, she became increasingly drowsy with a worsening headache. Computed tomography of the head revealed intracerebral hemorrhage and bilateral subarachnoid hemorrhage and computed tomography angiography demonstrated a 9 × 5 mm A2 aneurysm. She subsequently underwent embolization to treat the ruptured aneurysm. She recovered well neurologically, and subsequent cardiac imaging revealed a complete resolution of her prior issues.","PeriodicalId":94008,"journal":{"name":"Exploratory research and hypothesis in medicine","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135730748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Influencing Extravasation of Newborn Intravenous Infusions: A Review 新生儿静脉输液外渗的影响因素综述

Exploratory research and hypothesis in medicine Pub Date : 2023-10-13 DOI: 10.14218/erhm.2023.00030

Fang Huang, Lixuan Huang, Fengzhen Liao, Jiangping Huang, Jiaojiao Wei, Qun Liang, Zhenpeng Huang

引用次数: 0

Applications of Artificial Intelligence in Medicine 人工智能在医学中的应用

Exploratory research and hypothesis in medicine Pub Date : 2023-09-19 DOI: 10.14218/erhm.2023.00048

Ruby Srivastava

{"title":"Applications of Artificial Intelligence in Medicine","authors":"Ruby Srivastava","doi":"10.14218/erhm.2023.00048","DOIUrl":"https://doi.org/10.14218/erhm.2023.00048","url":null,"abstract":"Artificial intelligence (AI) with machine learning tools are used to search, store, and analyze medical data to benefit both physicians and the health of patients in various ways. With the advancement in machine learning algorithms and bioinformatics techniques, AI has become an essential part of modern healthcare society. AI algorithms and deep learning applications support clinicians with managing health records, making diagnoses and clinical decisions, prescribing medication, determining mental health, and imaging analysis. Clinicians gain rapid access to information and research relevant to the needs of the patients. As some algorithms compete with and sometimes outperform clinicians, it is necessary to fully integrate this technology into daily medical practices. However, we must recognize the strengths and weaknesses of AI, and obtain the perspectives of experts outside the medical field to enable the inclusion of the ethical, philosophical, sociological, psychological, behavioral, and economical aspects of machine behavior when understanding the evolving interaction of machines with humans, so that it can be used for advantageous purposes. AI technology cannot be considered a replacement for physicians, rather it can act as multiple task-oriented device support to ease the burden on clinicians so that they can provide better care of life to patients at every level.","PeriodicalId":94008,"journal":{"name":"Exploratory research and hypothesis in medicine","volume":"179 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135060917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional Support Following Traumatic Brain Injury: A Comprehensive Review. 创伤性脑损伤后的营养支持：综述。

Exploratory research and hypothesis in medicine Pub Date : 2023-09-01 Epub Date: 2022-08-15 DOI: 10.14218/erhm.2022.00086

Divine Nwafor, Joel Goeckeritz, Zahra Hasanpour, Caroline Davidson, Brandon Lucke-Wold

引用次数: 0