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Current opinion in immunology最新文献

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Editorial overview: Framing the logic of type 2 immunity. 编辑综述：构建 2 型免疫的逻辑。
Current opinion in immunology Pub Date : 2025-02-01 Epub Date: 2024-12-16 DOI: 10.1016/j.coi.2024.102523
Caroline L Sokol, Rod A Rahimi
{"title":"Editorial overview: Framing the logic of type 2 immunity.","authors":"Caroline L Sokol, Rod A Rahimi","doi":"10.1016/j.coi.2024.102523","DOIUrl":"10.1016/j.coi.2024.102523","url":null,"abstract":"","PeriodicalId":93967,"journal":{"name":"Current opinion in immunology","volume":"92 ","pages":"102523"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patterns of bacterial viability governing noncanonical inflammasome activation. 控制非典型炎性体活化的细菌活力模式。
Current opinion in immunology Pub Date : 2025-02-01 Epub Date: 2024-12-14 DOI: 10.1016/j.coi.2024.102512
Yuhua Shi, J Magarian Blander
{"title":"Patterns of bacterial viability governing noncanonical inflammasome activation.","authors":"Yuhua Shi, J Magarian Blander","doi":"10.1016/j.coi.2024.102512","DOIUrl":"10.1016/j.coi.2024.102512","url":null,"abstract":"<p><p>Noncanonical inflammasomes are instrumental in defense against Gram-negative bacteria, activated primarily by bacterial lipopolysaccharide. This review examines commonalities and distinctions in noncanonical inflammasome activation either by virulence factor activity indicating cellular invasion or by detection of bacterial mRNA signaling the undesired presence of live bacteria in sterile tissue. These inflammasome triggers, alongside other examples discussed, reflect properties exclusive to live bacteria. The emerging picture underscores noncanonical inflammasome activation hinging on detection of indicators of bacterial viability such as the presence of certain molecules or activity of specific processes. The complex interpretation of combinatorial signals is essential for inflammasome activation according to the specific facet of infection confronting the host. Decoding these signals and their convergence on inflammasome activation will inform interventions and therapies for infectious diseases.</p>","PeriodicalId":93967,"journal":{"name":"Current opinion in immunology","volume":"92 ","pages":"102512"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating the metabolic landscape of regulatory T cells: from autoimmune diseases to tumor microenvironments. 导航调节性 T 细胞的代谢景观：从自身免疫性疾病到肿瘤微环境。
Current opinion in immunology Pub Date : 2025-02-01 Epub Date: 2024-12-13 DOI: 10.1016/j.coi.2024.102511
Janika Härm, Yu-Tong Fan, Dirk Brenner
{"title":"Navigating the metabolic landscape of regulatory T cells: from autoimmune diseases to tumor microenvironments.","authors":"Janika Härm, Yu-Tong Fan, Dirk Brenner","doi":"10.1016/j.coi.2024.102511","DOIUrl":"10.1016/j.coi.2024.102511","url":null,"abstract":"<p><p>Regulatory T cells (Tregs) are essential for maintaining immune homeostasis, playing crucial roles in modulating autoimmune conditions and contributing to the suppressive tumor microenvironment. Their cellular metabolism governs their generation, stability, proliferation, and suppressive function. Enhancing Treg metabolism to boost their suppressive function offers promising therapeutic potential for alleviating inflammatory symptoms in autoimmune diseases. Conversely, inhibiting Treg metabolism to reduce their suppressive function can enhance the efficacy of traditional immunotherapy in cancer patients. This review explores recent advances in targeting Treg metabolism in autoimmune diseases and the metabolic adaptations of Tregs within the tumor microenvironment that increase their immunosuppressive function.</p>","PeriodicalId":93967,"journal":{"name":"Current opinion in immunology","volume":"92 ","pages":"102511"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccine policies in France and Europe. 法国和欧洲的疫苗政策。
Current opinion in immunology Pub Date : 2025-02-01 Epub Date: 2024-12-14 DOI: 10.1016/j.coi.2024.102513
Alain Fischer, Patrick Peretti-Watel, Jeremy Ward
{"title":"Vaccine policies in France and Europe.","authors":"Alain Fischer, Patrick Peretti-Watel, Jeremy Ward","doi":"10.1016/j.coi.2024.102513","DOIUrl":"10.1016/j.coi.2024.102513","url":null,"abstract":"<p><p>This review outlines the outcome of the COVID-19 vaccination campaign in France and assesses the respective roles of information and coercion in its overall success. These data are then put into perspective of the evolution of vaccination acceptance in France.</p>","PeriodicalId":93967,"journal":{"name":"Current opinion in immunology","volume":"92 ","pages":"102513"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of allergen-specific regulatory T cells in the control of allergic disease. 过敏原特异性调节性T细胞在过敏性疾病控制中的作用。
Current opinion in immunology Pub Date : 2025-02-01 Epub Date: 2024-12-06 DOI: 10.1016/j.coi.2024.102509
Athanasios Stoumpos, Guido Heine, Carina Saggau, Alexander Scheffold
{"title":"The role of allergen-specific regulatory T cells in the control of allergic disease.","authors":"Athanasios Stoumpos, Guido Heine, Carina Saggau, Alexander Scheffold","doi":"10.1016/j.coi.2024.102509","DOIUrl":"10.1016/j.coi.2024.102509","url":null,"abstract":"<p><p>Allergies result from an antigen-specific loss of tolerance against innocuous foreign substances. Allergen immunotherapy (AIT) aims to reverse the pathogenic response and to re-establish physiological tolerance. However, the tolerogenic mechanisms that prevent allergy in healthy and act during AIT are still obscure. Foxp3 expressing 'regulatory' CD4 T cells (Tregs) are essential mediators of tolerance against allergens. It remains controversial which antigen specificity of Tregs is required to prevent allergy and the role of allergen-specific Tregs during AIT. Recent work provided precise insight into physiological T cell responses against environmental and food compounds. This identified Treg responses mainly against peptides and proteins not involved in immune pathology, revealing an unexpected role of Treg antigen specificity for tolerance. This review will focus on antigen-specific Treg responses against food and airborne allergens, and the impact of the technological approach utilized for antigen-specific Treg characterization is discussed, with critical points to be addressed in future research.</p>","PeriodicalId":93967,"journal":{"name":"Current opinion in immunology","volume":"92 ","pages":"102509"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemokines that govern T cell activity in tumors. 肿瘤中控制T细胞活性的趋化因子。
Current opinion in immunology Pub Date : 2025-02-01 Epub Date: 2024-12-11 DOI: 10.1016/j.coi.2024.102510
Thorsten R Mempel, Mohsen Malehmir
{"title":"Chemokines that govern T cell activity in tumors.","authors":"Thorsten R Mempel, Mohsen Malehmir","doi":"10.1016/j.coi.2024.102510","DOIUrl":"10.1016/j.coi.2024.102510","url":null,"abstract":"<p><p>Local regulation of T cell-mediated immunity to solid tumors occurs at multiple levels, including their recruitment from the bloodstream to the tumor microenvironment (TME), coordinated crosstalk with different subsets of antigen-presenting cells (APCs) controlling their local survival, proliferation, and effector differentiation, as well as their egress from tumors via lymphatics. At each level, chemokines play essential roles, for instance, by guiding directional T cell migration across blood and lymphatic endothelial barriers or by promoting their spatial proximity and direct physical interactions with APCs to enable functional crosstalk. In this article, we will review recent mechanistic insights into the chemokine axes that guide T cell functions in TMEs in light of the emerging functional state heterogeneity of CD8<sup>+</sup> effector T cells and our growing understanding of how regulatory T cells restrain antitumor activity.</p>","PeriodicalId":93967,"journal":{"name":"Current opinion in immunology","volume":"92 ","pages":"102510"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuberculosis as an unconventional interferonopathy. 肺结核是一种非常规的干扰素病。
Current opinion in immunology Pub Date : 2025-02-01 Epub Date: 2024-12-04 DOI: 10.1016/j.coi.2024.102508
Russell E Vance
{"title":"Tuberculosis as an unconventional interferonopathy.","authors":"Russell E Vance","doi":"10.1016/j.coi.2024.102508","DOIUrl":"10.1016/j.coi.2024.102508","url":null,"abstract":"<p><p>Tuberculosis is caused by Mycobacterium tuberculosis, a bacterium that accounts for more human mortality than any other. Evidence is accumulating for the view that tuberculosis is an interferonopathy - a disease driven by type I interferons. However, how type I interferons exacerbate tuberculosis remains poorly understood. As an infection, tuberculosis is distinct from conventional interferonopathies, which are autoinflammatory diseases. Here I consider the hypothesis that type I interferons promote bacterial replication by impairing key antibacterial immune responses, including those orchestrated by interleukin-1 and interferon γ. Paradoxically, during tuberculosis, the underlying state of impaired antibacterial immunity co-exists with overt (but ineffective) inflammation. Conceiving of tuberculosis as an unconventional interferonopathy may suggest fruitful avenues for therapeutic intervention.</p>","PeriodicalId":93967,"journal":{"name":"Current opinion in immunology","volume":"92 ","pages":"102508"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolism and metabolites regulating hematopoiesis. 代谢和代谢产物调节造血。
Current opinion in immunology Pub Date : 2025-01-18 DOI: 10.1016/j.coi.2025.102525
Baihao Zhang, Sidonia Fagarasan
{"title":"Metabolism and metabolites regulating hematopoiesis.","authors":"Baihao Zhang, Sidonia Fagarasan","doi":"10.1016/j.coi.2025.102525","DOIUrl":"https://doi.org/10.1016/j.coi.2025.102525","url":null,"abstract":"<p><p>Energy metabolism of immune cells, such as glycolysis and mitochondrial activity, requires strict regulation. This is especially critical in the complex environment of the bone marrow (BM), where there is a need to both preserve the quiescence of hematopoietic stem cells (HSCs) and guarantee timed and effective lineage differentiation of the HSCs. Recent advances highlight the critical roles played by bioactive metabolites in regulating hematopoiesis. In particular, secreted immune metabolites (SIMets), such as γ-aminobutyric acid (GABA) and acetylcholine, secreted by B-lineage cells, act as potent modulators of hematopoietic processes, influencing HSC differentiation and emergency hematopoiesis. In this review, we provide an overview and discuss mechanisms by which energy metabolism and SIMets regulate hematopoiesis. We propose that biochemical communication facilitated by these metabolites is essential for maintaining the BM niche and suggest potential therapeutic strategies using SIMets in hematological disorders.</p>","PeriodicalId":93967,"journal":{"name":"Current opinion in immunology","volume":"93 ","pages":"102525"},"PeriodicalIF":0.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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