Biochimica et biophysica acta. Molecular basis of disease最新文献_第2页

Expression of concern for "Carcinogen-induced early molecular events and its implication in the initiation of chemical hepatocarcinogenesis in rats: Chemopreventive role of vanadium on this process' by Malay Chatterjee" [Biochim. Biophys. Acta (BBA) Mol. Basis Dis. 1772 (1) (January 2007) 48-59 https://doi.org/10.1016/j.bbadis.2006.10.019]. Malay Chatterjee对“致癌物诱导的早期分子事件及其在大鼠化学性肝癌发生中的意义：钒在这一过程中的化学预防作用”的关注表达[生物化学]。Biophys。生物学报，1772(1)（2007年1月）48-59 https://doi.org/10.1016/j.bbadis.2006.10.019]。

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2026-08-01 Epub Date: 2026-03-20 DOI: 10.1016/j.bbadis.2026.168228

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WITHDRAWN: Corrigendum to "NADPH oxidase 5 promotes adhesion and infiltration of immune cells in the brain. Implications in ischemic stroke" [Biochim. Biophys. Acta (BBA) - Mol. Basis Dis. (2026) volume 1872, issue 4, 168188]. 撤回：“NADPH氧化酶5促进大脑中免疫细胞的粘附和浸润”的更正。对缺血性中风的影响[生物化学]。Biophys。学报(BBA) - Mol. Basis Dis.（2026）卷1872，第4期，168188]。

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2026-03-03 DOI: 10.1016/j.bbadis.2026.168199

Javier Marqués, Leyre Basurco, Elena Ainzúa, Victor Marqués, Maite Solas, Enrique Santamaría, Joaquín Fernández-Irigoyen, Davide Maselli, María Martínez-Azcona, Carmen Roncal, Maria S Aymerich, Aleksandar Ivetic, Josune Orbe, Guillermo Zalba

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Integrated transcriptomics and metabolomics revealed improvement of the nervous system in old rats by aspirin eugenol ester. 综合转录组学和代谢组学显示阿司匹林丁香酚酯对老年大鼠神经系统有改善作用。

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2025-11-01 Epub Date: 2025-08-06 DOI: 10.1016/j.bbadis.2025.168009

Qi Tao, Ji Feng, Li-Ping Fan, Zhi-Jie Zhang, Chen-Jing Feng, Jian-Yong Li, Ya-Jun Yang

{"title":"Integrated transcriptomics and metabolomics revealed improvement of the nervous system in old rats by aspirin eugenol ester.","authors":"Qi Tao, Ji Feng, Li-Ping Fan, Zhi-Jie Zhang, Chen-Jing Feng, Jian-Yong Li, Ya-Jun Yang","doi":"10.1016/j.bbadis.2025.168009","DOIUrl":"10.1016/j.bbadis.2025.168009","url":null,"abstract":"Elderly groups usually have an inflammatory response in their bodies, and neuroinflammation is the main pathogenic mechanism of neurological diseases. Pharmacological and pharmacodynamic experiments showed that aspirin eugenol ester (AEE) had good anti-inflammatory, anti-oxidant and anti-hyperlipidemic effects. However, whether AEE can prevent neurological diseases in the old companion animal has not been explored. In this study, we selected adolescent rats (6 weeks old) and old rats (18 months old) as the experimental animals for two weeks. The transcriptomics and metabolomics methods were used to explore the effects of AEE on the hippocampal region in the brains of old rats. The related indexes were detected. AEE significantly reduced the levels of pro-inflammatory cytokines and oxidative stress in lipopolysaccharide (LPS) induced microglia of rats. AEE significantly increased the duration of swimming observed in the forced swimming test for older rats, but did not have a significant effect between adolescent rats. Hematoxylin and eosin staining (HE) showed that AEE had no significant effects on the kidney and gastrointestinal tract and could improve liver function in old rats. AEE improved genes and metabolites in the hippocampal region of the old rat brain. Comprehensive analysis of transcriptomics and metabolomics showed that the gene Chacna3 was correlated positively with metabolic phosphatidylethanolamine (PE) and phosphatidylcholine (PC), and the genes Tnfsf10 and Cacna1f were correlated positively with metabolic PE and PC and negatively with eicosapentaenoic acid (Epa). AEE could play positive effects on preventing neurological diseases in old companion animal.","PeriodicalId":93896,"journal":{"name":"Biochimica et biophysica acta. Molecular basis of disease","volume":" ","pages":"168009"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144801221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hippocampal proteomic signatures of the ketogenic diet in a model of infantile epileptic spasms syndrome. 婴儿癫痫痉挛综合征模型中生酮饮食的海马蛋白质组学特征。

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2025-11-01 Epub Date: 2025-08-05 DOI: 10.1016/j.bbadis.2025.168011

Jaclyn C Campbell, Chunlong Mu, Tina R Ram, Daniel Young, Antoine Dufour, Morris H Scantlebury, Jane Shearer

引用次数: 0

An epigenetic perspective of viral diseases, including cancer and autophagy. 病毒疾病的表观遗传学观点，包括癌症和自噬。

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2025-03-01 Epub Date: 2025-01-10 DOI: 10.1016/j.bbadis.2025.167664

Samir Kumar Patra

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A potential early-atheroprotective target: Irgm1 mediates lymphangiogenesis through LEC autophagy by Tfeb translocation. 潜在的早期动脉粥样硬化保护靶标：Irgm1 通过 Tfeb 转位介导淋巴管自噬。

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2024-08-01 Epub Date: 2024-05-15 DOI: 10.1016/j.bbadis.2024.167238

Hengxuan Cai, Guanpeng Ma, Zhenming Zhang, Guojie Liu, Rongzhe Lu, Yige Liu, Jiaxin Wang, Shanjie Wang, Song Sun, Mingyan E, Zhaoying Li, Shaohong Fang, Bo Yu

{"title":"A potential early-atheroprotective target: Irgm1 mediates lymphangiogenesis through LEC autophagy by Tfeb translocation.","authors":"Hengxuan Cai, Guanpeng Ma, Zhenming Zhang, Guojie Liu, Rongzhe Lu, Yige Liu, Jiaxin Wang, Shanjie Wang, Song Sun, Mingyan E, Zhaoying Li, Shaohong Fang, Bo Yu","doi":"10.1016/j.bbadis.2024.167238","DOIUrl":"10.1016/j.bbadis.2024.167238","url":null,"abstract":"Lymphatic dysfunction is a pivotal pathological mechanism underlying the development of early atherosclerotic plaques. Potential targets of lymphatic function must be identified to realize the early prevention and treatment of atherosclerosis (AS). The immunity-related GTPase Irgm1 is involved in orchestrating cellular autophagy and apoptosis. However, the effect of Irgm1 on early AS progression, particularly through alterations in lymphatic function, remains unclear. In this study, we confirmed the protective effect of lymphangiogenesis on early-AS in vivo. Subsequently, an in vivo model of early AS mice with Irgm1 knockdown shows that Irgm1 reduces early atherosclerotic plaque burden by promoting lymphangiogenesis. Given that lymphatic endothelial cell (LEC) autophagy significantly contributes to lymphangiogenesis, Irgm1 may enhance lymphatic circulation by promoting LEC autophagy. Moreover, Irgm1 orchestrates autophagy in LECs by inhibiting mTOR and facilitating nuclear translocation of Tfeb. Collectively, these processes lead to lymphangiogenesis. Thus, this study establishes a link between Irgm1 and early AS, thus revealing a novel mechanism by which Irgm1 exerts an early protective influence on AS within the context of lymphatic circulation. The insights gained from this study have the potential to revolutionize the approach and management of AS onset.","PeriodicalId":93896,"journal":{"name":"Biochimica et biophysica acta. Molecular basis of disease","volume":" ","pages":"167238"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Exogenous recombinant N-acetylgalactosamine-4-sulfatase (Arylsulfatase B; ARSB) inhibits progression of B16F10 cutaneous melanomas and modulates cell signaling" [Biochim. Biophys. Acta Mol. Basis Dis. 1870(1) (2024)166913-25, PMID: 37813168]. 外源重组 N-乙酰半乳糖胺-4-硫酸酯酶（Arylsulfatase B; ARSB）抑制 B16F10 皮肤黑色素瘤的进展并调节细胞信号传导》[Biochim.Biochim.Acta Mol.Basis Dis.1870(1) (2024)166913-25, PMID: 37813168]。

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2024-05-16 DOI: 10.1016/j.bbadis.2024.167231

Sumit Bhattacharyya, Insug O-Sullivan, Jieqi Tu, Zhengjia Chen, Joanne K Tobacman

引用次数: 0