Alcohol (Fayetteville, N.Y.)最新文献

{"title":"Explaining increased efficacy of naltrexone in the treatment of alcohol dependent patients with a family history of alcohol use disorder: A systematic review on the role of reward sensitivity and sweet liking.","authors":"Jan van Amsterdam, Wim van den Brink","doi":"10.1016/j.alcohol.2025.06.004","DOIUrl":"10.1016/j.alcohol.2025.06.004","url":null,"abstract":"<p><p>A positive family history of alcohol use disorder (FHA+) is one of the strongest risk factors for developing alcohol use disorder (AUD) compared. Importantly, naltrexone (NTX) has shown higher efficacy in treating FHA+ AUD patients than FHA- AUD patients. Possibly, this may be explained by the attenuation of high reward sensitivity and liking sweet substances (\"sweet liking\"; SL) in FHA+ AUD patients. This systematic review explores whether attenuation by NTX of reward sensitivity and SL explains its higher efficacy in FHA+ compared to FHA- AUD patients. Separate systematic literature searches were performed on the effect of NTX in FHA+ AUD patients, the effect of NTX on reward sensitivity, and the associations of FHA+ with reward sensitivity and SL. In total, 36 eligible studies were included (6 for the effect of NTX in FHA+ AUD patients, 18 for reward sensitivity, and 12 for sweet liking). In 5 out of 6 studies, a moderating effect of FHA+ on NTX treatment efficacy in AUD was shown, with higher efficacy of NTX in FHA+ AUD patients. In 6 out of 8 studies, reward sensitivity moderated the treatment effect of NTX in AUD, and in 9 of 10 studies, reward sensitivity was attenuated by NTX. In 3 studies, SL positively moderated the effect of NTX in AUD. Finally, in 9 of 9 studies, SL was attenuated by NTX and enhanced by (partial) opioid agonists. Increased reward sensitivity (and sweet-liking as its possible indicator) appeared to be positively associated with FHA+ and was attenuated by NTX, which may (partly) explain the increased effect of NTX in FHA+ AUD patients. These results may foster personalized pharmacotherapy in AUD patients.</p>","PeriodicalId":93864,"journal":{"name":"Alcohol (Fayetteville, N.Y.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Physical Pain, Alcohol Use, and Related Factors in the Daily Lives of Patients with Chronic Low Back Pain.","authors":"Ian A McNamara, Jeff Boissoneault, Jarrod M Ellingson, Jake Sauer, Ryan W Carpenter","doi":"10.1016/j.alcohol.2025.06.002","DOIUrl":"https://doi.org/10.1016/j.alcohol.2025.06.002","url":null,"abstract":"<p><strong>Background: </strong>Alcohol use and chronic pain are highly prevalent, costly, and have a bidirectional relationship. This may occur, in part, because of the analgesic effects of alcohol. Specifically, individuals may drink alcohol to address both physical pain and the subsequent increases in negative affect that may be brought on by painful experiences. The current project examined the Catastrophizing, Anxiety, Negative Urgency, and Expectancy (CANUE) model in daily life to better understand the association between alcohol use and pain.</p><p><strong>Methods: </strong>Hypothesized paths of the CANUE model were examined using intensive longitudinal data (n=34; total n_observations=2,960) collected using ecological momentary assessment over fourteen days from patients with chronic lower back pain who reported drinking alcohol (n_{drinking episodes}=5.88). Multilevel models examined associations of pain, negative affect, and alcohol use, as well as potential moderators (pain-related cognitions, alcohol expectancies, and impulsivity) of these associations.</p><p><strong>Results: </strong>Previous-occasion physical pain, but not cumulative-average pain, and pain-related alcohol expectancies, were associated with a greater likelihood of alcohol use. Though there was no main effect of cumulative-average negative affect on alcohol use, negative affect interacted with impulsivity, such that participants were more likely to continue drinking when experiencing increased negative affect and impulsivity. Results did not find a hypothesized indirect effect of pain on alcohol use via negative affect. Alcohol use was associated with reduced next-occasion pain and increased perceptions of alcohol-related pain relief.</p><p><strong>Discussion: </strong>While cumulative-average pain was not associated with an increased likelihood of drinking, individuals were more likely to drink after occasions of elevated pain. This may indicate that participants drank to reduce pain, as was also suggested by the association between pain-related alcohol expectancies and drinking. This is one of the first studies to examine associations of alcohol use and chronic pain in daily life. The results provide evidence for the importance of pain as an antecedent to alcohol use. Findings supported some components of the CANUE model but also highlight the need for further investigation to inform potential revision of the mode.</p>","PeriodicalId":93864,"journal":{"name":"Alcohol (Fayetteville, N.Y.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol use disorder exacerbates clinical and vascular risks differentially in Psychiatric disorders.","authors":"Eva Christina Meyer, Younes Adam Tabi","doi":"10.1016/j.alcohol.2025.06.003","DOIUrl":"https://doi.org/10.1016/j.alcohol.2025.06.003","url":null,"abstract":"<p><p>Alcohol Use Disorder (AUD) is a major public health concern with detrimental effects on cognitive and neurological function, yet its impact on psychiatric populations remains incompletely defined. In this global propensity score-matched cohort study, we examined the clinical and vascular consequences of comorbid alcohol abuse across diverse psychiatric disorders. Data from the TriNetX network, encompassing electronic medical records from 143 healthcare organizations, were analyzed. For each disorder-anxiety, depression, bipolar disorder, schizophrenia, reaction to severe stress, eating disorders, personality disorders, psychoactive substance dependence, developmental disorders, and obsessive-compulsive disorder-patients with alcohol abuse were matched 1:1 to those without, controlling for demographic and clinical factors. Over a 1,095-day follow-up, outcomes evaluated included emergency department visits, pain prevalence, mortality, and cerebrovascular events (transient ischemic attacks and strokes). Alcohol abuse was consistently associated with significantly higher emergency care utilization, increased somatic pain, and elevated mortality across all groups. For instance, anxiety and depression cohorts exhibited 8.1% and 7.3% higher emergency visits and increased mortality by 2.7% and 2.4%, respectively, while schizophrenia showed a twofold increase in stroke risk and markedly higher pain (risk ratio 2.21). These results underscore that AUD exacerbates clinical and vascular risks in psychiatric patients, highlighting the urgent need for targeted interventions.</p>","PeriodicalId":93864,"journal":{"name":"Alcohol (Fayetteville, N.Y.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}