{"title":"The Immune System","authors":"Eryl Liddell, I. Weeks","doi":"10.1201/9781003077077-1","DOIUrl":"https://doi.org/10.1201/9781003077077-1","url":null,"abstract":"The immune system consists of a large number of different types of cells and proteins that function to distinguish between normal and abnormal cellular components and between 'self' and 'non-self'. As an example, when a thorn gets stuck in the body, the immune cells are able to recognized the thorn as a foreign object (i.e. 'non-self') and attack it. The same is true for bacteria, viruses or other organisms that can invade our bodies. A more subtle distinction between self and non-self occurs in the recognition of cancer cells by the forces of the immune system. The cancer cells are recognized and attacked because they differ from the normal 'self' from which they arose.","PeriodicalId":93730,"journal":{"name":"Antibody technology journal","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81521576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hong Nguyen, Jolene Mariotti, Diana Bareyan, Robert Carnahan, Tracy Cooper, Christopher Williams, Michael Engel
{"title":"ANTI-MTG16 ANTIBODIES REVEAL MTG16 SUBCELLULAR DISTRIBUTION AND NUCLEOCYTOPLASMIC TRANSPORT IN ERYTHROLEUKEMIA CELLS.","authors":"Hong Nguyen, Jolene Mariotti, Diana Bareyan, Robert Carnahan, Tracy Cooper, Christopher Williams, Michael Engel","doi":"10.2147/anti.s74419","DOIUrl":"https://doi.org/10.2147/anti.s74419","url":null,"abstract":"<p><p>The myeloid translocation gene (MTG) family of transcriptional co-repressors consists of three highly conserved members; MTG8, MTG16 and MTGR1, each evolutionarily related to the <i>Drosophila</i> protein NERVY and with orthologs across the mammalian hierarchy. By coordinating coincident interactions between DNA binding proteins, other co-repressors and epigenetic effectors, MTG proteins occupy a critical nexus in transcriptional control complexes to profoundly impact the specification of cell fate. MTG family members are most conserved within Nervy Homology Regions (NHR) 1-4, with each region fulfilling functions common to the family. Studies of functional differences between MTG proteins require carefully qualified immunologic reagents specific to each family member. We have developed a group of α-MTG16 antibodies and carefully characterized their specificity for MTG16. These tools reveal that MTG16 is concentrated in the cytoplasm of erythroleukemia cell lines from human and mouse. Using the CRM1 antagonist, leptomycin-B, we show that MTG16 levels rise in the nucleus of MEL cells and decline in the cytoplasm. Together, these data indicate bidirectional movement of MTG16 between cytoplasmic and nuclear compartments. Our work reveals an unrecognized feature of MTG16 regulation that may impact cell fate specification and provides reagents to address important questions regarding MTG16 functions <i>in vivo</i>.</p>","PeriodicalId":93730,"journal":{"name":"Antibody technology journal","volume":"5 ","pages":"27-41"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/anti.s74419","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40562866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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