Margaret Simonian, David S K Lu, Julian Whitelegge, Whitaker Cohn, Preeti Ahuja, William Hsu, Steven S Raman
{"title":"Comparison of LIRADS 5 Image Guided Core Biopsy Derived From Formalin Fixed and Frozen Tissue Cores for Radiogenomics and Radioproteomics Analysis in Well, Moderate and Poorly Differentiated Hepatocellular Carcinoma.","authors":"Margaret Simonian, David S K Lu, Julian Whitelegge, Whitaker Cohn, Preeti Ahuja, William Hsu, Steven S Raman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of this pilot study is to evaluate and compare the quality of the genomics and proteomics data obtained from paired Formalin Fixed Paraffin Embedded (FFPE) and frozen (FF) tissue percutaneous core biopsies of Liver Imaging Reporting and Data System 5 (LIRADS 5) hepatocellular carcinoma (HCC) of varying histological grades. The preliminary data identified differentially expressed proteins and genes in poor, moderate and well differentiated HCC biopsies, with a greater efficacy in fresh frozen samples. The data offered valuable insights into the characteristics and suitability of samples for future studies.</p>","PeriodicalId":93560,"journal":{"name":"Global medicine and therapeutics","volume":"6 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11138132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Osteoarthritis in a symptomatic coracoclavicular joint","authors":"A. Schuh, F. Seehaus, N. Onyemaechi, W. Hönle","doi":"10.15761/gmt.1000106","DOIUrl":"https://doi.org/10.15761/gmt.1000106","url":null,"abstract":"Coracoclavicular joint (CCJ) is a rare cause of shoulder pain. CCJ is not described in most orthopaedic textbooks, leading to lack of awareness in the general orthopaedic community. In that way the incidence of symptomatic cases is underestimated. We present the case of a symptomatic osteoarthtritic CCJ in a 46-year-old male patient with nearly complete relief of pain after therapeutic injection of the CCJ. The radiological signs of CCJ are briefly discussed to increase awareness of this very rare entity.","PeriodicalId":93560,"journal":{"name":"Global medicine and therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47516168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kunio Yui, Hitomi Sasaki, George Imataka, Tohru Okanishi
{"title":"The role of antioxidant proteins in improvement of autism core symptoms in two patients with tuberous sclerosis treated with mTOR inhibitor everolimus","authors":"Kunio Yui, Hitomi Sasaki, George Imataka, Tohru Okanishi","doi":"10.15761/gmt.1000101","DOIUrl":"https://doi.org/10.15761/gmt.1000101","url":null,"abstract":"The neuropsychiatric clinical manifestations of tuberous sclerosis complex (TSC) include social and behavioral impairment, which are similar to the core symptoms of autism spectrum disorder (ASD). The present study examined the clinical effects of the mTOR inhibitor everolimus for 24 weeks on social and behavioral symptoms, and its relation of serum levels of the copper-and iron-binding antioxidants, such as ceruloplasmin (Cp) and transferrin (Tf), and superoxide dismutase (SOD) in a pre-pubercent boy and a girl child with TSC.","PeriodicalId":93560,"journal":{"name":"Global medicine and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.oatext.com/pdf/GMT-1-101.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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