Proceedings of stem cell research and oncogenesis最新文献

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Stem Cells in Ovarian Cancer and Potential Therapies. 卵巢癌中的干细胞及潜在疗法。
Proceedings of stem cell research and oncogenesis Pub Date : 2020-05-01 Epub Date: 2020-05-03
Elena Zuber, Diana Schweitzer, Dominick Allen, Seema Parte, Sham S Kakar
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引用次数: 0
Novel view of the adult stem cell compartment - a developmental story of germline and parental imprinting. 成体干细胞室的新观点-种系和亲代印记的发育故事。
Proceedings of stem cell research and oncogenesis Pub Date : 2019-01-01 Epub Date: 2019-06-17
Mariusz Z Ratajczak, Alison Domingues, Suman Suman, Alex R Straughn, Sham S Kakar, Malwina Suszynska
{"title":"Novel view of the adult stem cell compartment - a developmental story of germline and parental imprinting.","authors":"Mariusz Z Ratajczak,&nbsp;Alison Domingues,&nbsp;Suman Suman,&nbsp;Alex R Straughn,&nbsp;Sham S Kakar,&nbsp;Malwina Suszynska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Evidence has accumulated that postnatal tissues contain developmentally early stem cells that remain in a dormant state as well as stem cells that are more proliferative, supplying tissue-specific progenitor cells and thus playing a more active role in the turnover of adult tissues. The most primitive, dormant, postnatal tissue-derived stem cells, called very small embryonic like stem cells (VSELs), are regulated by epigenetic changes in the expression of certain parentally imprinted genes, a molecular phenomenon previously described for maintaining primordial germ cells (PGCs) in a quiescent state. Specifically, they show erasure of parental imprinting at the Igf2-H19 locus, which keeps them in a quiescent state in a similar manner as migrating PGCs. To date, the presence of these cells in adult postnatal tissues have been demonstrated by at least 25 independent laboratories. We envision that similar changes in expression of parentally imprinted genes may also play a role in the quiescence of dormant VSELs present in other non-hematopoietic tissues. Recent data indicate that VSELs expand <i>in vivo</i> and <i>in vitro</i> after reestablishment of somatic imprinting at the Igf2-H19 locus by nicotinamide treatment in response to stimulation by pituitary gonadotrophins (follicle stimulating factor, luteinizing hormone and prolactin) and gonadal androgens and estrogens. These cells could be also successfully expanded <i>ex vivo</i> in the presence of the small molecule UM177.</p>","PeriodicalId":93045,"journal":{"name":"Proceedings of stem cell research and oncogenesis","volume":"7 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375353/pdf/nihms-1037560.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38181784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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