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Current Topics In Virology最新文献

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SARS-CoV-2 morphology, genome, life cycle and our bodies’ immune response: a review SARS-CoV-2形态、基因组、生命周期和我们身体的免疫反应:综述
Current Topics In Virology Pub Date : 2021-12-31 DOI: 10.31300/ctvr.18.2021.15-24
Ilyes Zatla, L. Boublenza, H. Hassaine
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引用次数: 0
SARS-CoV-2 origin, classification and transmission: a mini-review 严重急性呼吸系统综合征冠状病毒2型的起源、分类和传播：一项小型综述
Current Topics In Virology Pub Date : 2021-12-31 DOI: 10.31300/ctvr.18.2021.31-38
Ilyes Zatla, L. Boublenza, H. Hassaine
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引用次数: 1
Clinical spectrum of COVID-19 and plasma angiotensin II levels 新冠肺炎临床症状谱与血浆血管紧张素II水平
Current Topics In Virology Pub Date : 2021-12-31 DOI: 10.31300/ctvr.18.2021.25-30
U. Abbas, An-Lin Cheng, Shitalkumar Patel, Sidra Younus, G. Rivero, T. Lasco, M. Mohajer
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引用次数: 0
Neutralization and beyond: Antibodies and HIV-1 acquisition. 中和与超越：抗体与 HIV-1 感染。
Current Topics In Virology Pub Date : 2018-01-01
Allison S Thomas, Melissa Ghulam-Smith, Manish Sagar
{"title":"Neutralization and beyond: Antibodies and HIV-1 acquisition.","authors":"Allison S Thomas, Melissa Ghulam-Smith, Manish Sagar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It is widely accepted that an effective HIV-1 preventative vaccine must elicit antibodies that can block virus acquisition. Although, anti-HIV-1 broadly neutralizing antibodies (bnAbs) have been isolated, unfortunately, no vaccine immunogens have been designed that can elicit these bnAbs in uninfected at-risk individuals. Some studies have suggested that other antibody functionalities, besides neutralization, such as antibody-dependent cellular cytotoxicity (ADCC), may prevent HIV-1 acquisition. In contrast to bnAbs, ADCC-inducing antibodies may be more amenable to elicitation by current vaccine technologies. This review will provide clarity about the role of nAbs and ADCC-inducing antibodies in preventing transmission, highlight mechanisms that potentially explain how ADCC-mediating antibodies may work, and speculate about the generation of these novel protective antibodies. Anti-HIV-1 ADCC-inducing antibodies may provide a new avenue for developing an effective HIV-1 vaccine.</p>","PeriodicalId":92772,"journal":{"name":"Current Topics In Virology","volume":"15 ","pages":"73-86"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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