Journal of molecular genetics (Isleworth, London, England)最新文献

筛选

英文中文

The Novel ReNu Region of TAF12 Regulates Gcn5 Nucleosomal Acetylation. TAF12的新reu区调控Gcn5核小体乙酰化。

Journal of molecular genetics (Isleworth, London, England) Pub Date : 2019-11-01 Epub Date: 2019-06-10

Michael S Torok, Marilyn G Pray-Grant, Benjamin M Grant, Meagan E Josephs, Patrick A Grant

{"title":"The Novel ReNu Region of TAF12 Regulates Gcn5 Nucleosomal Acetylation.","authors":"Michael S Torok, Marilyn G Pray-Grant, Benjamin M Grant, Meagan E Josephs, Patrick A Grant","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The post-translational acetylation of the histone components of chromatin mediates numerous DNA-templated events, including transcriptional activation, DNA repair, and genomic replication. The conserved SAGA (Spt-Ada-Gcn5 Acetyltranferase) and SLIK (SAGA-Like) Histone Acetyltransferase (HAT) complexes are required for transcriptional activation of a subset of yeast genes and contain multiple subunits including the histone fold-containing TBP- Associated Factors (TAFs): 6, 9, 10, and 12. These TAFs are also components of the TFIID complex and are consequently involved in most RNA polymerase II-transcription in yeast. Here we identify a novel conserved region of TAF12, termed ReNu, outside of its histone fold, which is required for SAGA and SLIK-directed nucleosomal acetylation. We demonstrate that this region is not required for chromatin association, but show that this region plays an important role for histone H3 acetylation at specific SAGA and SLIK-regulated promoters. Our data suggests that the ReNu region of TAF12 regulates Gcn5 acetylation of specific substrates within the SAGA super-family of HAT complexes.</p>","PeriodicalId":92672,"journal":{"name":"Journal of molecular genetics (Isleworth, London, England)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437354/pdf/nihms-1616406.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38295533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fentanyl overdose in a female with the FMR1 premutation and FXTAS. 芬太尼过量死亡女性伴有FMR1突变和FXTAS。

Journal of molecular genetics (Isleworth, London, England) Pub Date : 2018-11-01 Epub Date: 2018-04-01 DOI: 10.31038/JMG.1000101

Marwa El-Deeb, Patrick Adams, Andrea Schneider, Maria J Salcedo-Arellano, Flora Tassone, Randi Hagerman

引用次数: 7