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Blood Neutrophil Count is Associated with Body Mass Index in Adolescents with Asthma. 青少年哮喘患者血中性粒细胞计数与体重指数的关系

JSM allergy and asthma Pub Date : 2018-01-01 Epub Date: 2018-05-11

Hyekyun Rhee, Tanzy Love, Donald Harrington

{"title":"Blood Neutrophil Count is Associated with Body Mass Index in Adolescents with Asthma.","authors":"Hyekyun Rhee, Tanzy Love, Donald Harrington","doi":"","DOIUrl":"","url":null,"abstract":"Background: Sputum neutrophils are associated with severe asthma, poor pulmonary function and high body mass index (BMI) in adult patients. However, little is known about the relationships between blood neutrophils, BMI and asthma severity in pediatric patients. This brief report is to assess the predictive value of blood neutrophils for asthma severity, BMI and pulmonary function in adolescents with asthma.Methods: The study included 166 adolescents with physician diagnosed asthma for at least 1 year. Participants were recruited from three metropolitan cities in the U.S. BMI-for-age percentile (BMI %) was determined by standardized charts and absolute neutrophil counts (cells/μL) were obtained from the complete blood count. Asthma severity was measured based on the national guidelines. Spirometry was performed to obtain percent predicted values for Forced Expiratory Volume in 1 second (FEV1), Forced Vital Capacity (FVC), and FEV1/FVC ratio as markers for pulmonary function.Results: The average age of participants was 14.79 years (± 1.86) and 54% were female. The majority (84%) were black. Fifty-five percent of the sample were either overweight (21%) or obese (34%). Blood neutrophil count was significantly correlated with BMI% (r=0.25, p=.001), but not with symptom severity (r=0.087, p=.268), FEV1 (r=-0.00, p=.937), or FVC (r=-0.010, p=.897).After controlling for sex, age, and age at asthma diagnosis, blood neutrophil count was a significant predictor for overweightness or obesity (OR=1.38, 95% CI 1.11, 1.75, p=0.01).Conclusions: Elevated blood neutrophils are associated with higher BMI, but not lung function or symptom severity in our adolescent sample with asthma. This study suggests blood neutrophils may be a potential inflammatory biomarker for overweightness and obesity in adolescents with asthma, but not for asthma morbidity.","PeriodicalId":92555,"journal":{"name":"JSM allergy and asthma","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287916/pdf/nihms973905.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36764799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Asthma on the Association between Childhood Obesity and Influenza. 哮喘对儿童肥胖和流感之间关系的影响

JSM allergy and asthma Pub Date : 2017-01-01 Epub Date: 2017-04-24

Meredith S Campbell, Seth W Gregory, Amy L Weaver, Kristin C Mara, Seema Kumar, Thomas G Boyce

{"title":"Impact of Asthma on the Association between Childhood Obesity and Influenza.","authors":"Meredith S Campbell, Seth W Gregory, Amy L Weaver, Kristin C Mara, Seema Kumar, Thomas G Boyce","doi":"","DOIUrl":"","url":null,"abstract":"Background: Despite long-standing recommendations for influenza vaccine in patients with asthma, whether asthma is a risk factor for medically-attended influenza is unclear. Obesity has more recently been found to be a risk factor for severe influenza in adults. Its role in children is less certain.Materials and methods: We conducted a 1:1 matched case-control study of all 185 children 2 to 18 years old with PCR-confirmed influenza at our institution from 2010 to 2013.Results: Having a prior history of asthma was 2 times more common (95% CI, 1.24-3.23) among the influenza cases than the controls. Obesity was not associated with influenza overall (OR 0.94, 95% CI 0.49-1.83). However, among patients with asthma, influenza cases were 4.4 times more likely to be obese compared with subjects without influenza (95% CI, 0.93-20.58).Conclusion: In our population, a prior diagnosis of asthma was associated with a two-fold increased risk of medically-attended influenza. In addition, among patients with asthma there was a trend toward obesity increasing the risk of influenza.","PeriodicalId":92555,"journal":{"name":"JSM allergy and asthma","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360396/pdf/nihms-1728628.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39326135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0