Journal of food bioactives : an official scientific publication of the International Society of Nutraceuticals and Functional Foods (ISNFF)最新文献

{"title":"Phytochemical characterization of <i>Tabernanthe iboga</i> root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice.","authors":"Bayissi Bading-Taika,&nbsp;Tunde Akinyeke,&nbsp;Armando Alcazar Magana,&nbsp;Jaewoo Choi,&nbsp;Michael Ouanesisouk,&nbsp;Eileen Ruth Samson Torres,&nbsp;Lisa A Lione,&nbsp;Claudia S Maier,&nbsp;Gerd Bobe,&nbsp;Jacob Raber,&nbsp;Cristobal L Miranda,&nbsp;Jan F Stevens","doi":"10.31665/JFB.2018.3154","DOIUrl":"https://doi.org/10.31665/JFB.2018.3154","url":null,"abstract":"<p><p>Preparations of the root bark of <i>Tabernanthe iboga</i> have long been used in Central and West African traditional medicine to combat fatigue, as a neuro-stimulant in rituals, and for treatment of diabetes. The principal alkaloid of <i>T. iboga,</i> ibogaine, has attracted attention in many countries around the world for providing relief for opioid craving in drug addicts. Using a plant metabolomics approach, we detected five phenolic compounds, including 3-<i>O</i>-caffeoylquinic acid, and 30 alkaloids, seven of which were previously reported from <i>T. iboga</i> root bark. Following a report that iboga extracts contain insulinotropic agents, we aimed to determine the potential alleviating effects of the water extract of iboga root bark on high-fat diet (HFD)-induced hyperglycemia as well as its effects on cognitive function in male C57BL/6J mice. Feeding a HFD to mice for 10 weeks produced manifestations of metabolic syndrome such as increased body weight and increased plasma levels of glucose, triacylglycerols, total cholesterol, LDL-cholesterol, insulin, leptin, and pro-inflammatory mediators (IL-6, MCP-1, ICAM-1), as compared to mice fed a low-fat diet (LFD). Supplementation of HFD with iboga extract at ibogaine doses of 0.83 (low) and 2.07 (high) mg/kg/day did not improve these HFD-induced metabolic effects except for a reduction of plasma MCP-1 in the low dose group, indicative of an anti-inflammatory effect. When the HFD mice were tested in the water maze, the high-dose iboga extract caused hippocampus-dependent impairments in spatial learning and memory, as compared to mice receiving only a HFD.</p>","PeriodicalId":92544,"journal":{"name":"Journal of food bioactives : an official scientific publication of the International Society of Nutraceuticals and Functional Foods (ISNFF)","volume":"3 ","pages":"111-123"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301038/pdf/nihms-992179.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36800877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}