Journal of clinical gastroenterology and hepatology最新文献

{"title":"WHY DOCTORS SHOULD HAVE THE MINDSET OF A PERFORMER?","authors":"B. Baker","doi":"10.21767/2575-7733-c1-010","DOIUrl":"https://doi.org/10.21767/2575-7733-c1-010","url":null,"abstract":"","PeriodicalId":92538,"journal":{"name":"Journal of clinical gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68153497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDY OF THE PROTEOMIC PROFILE IN PATIENTS WITH ULCERATIVE COLITIS, ITS CORRELATION WITH DIAGNOSIS AND DISEASE ACTIVITY","authors":"D. Header","doi":"10.21767/2575-7733-c1-011","DOIUrl":"https://doi.org/10.21767/2575-7733-c1-011","url":null,"abstract":"","PeriodicalId":92538,"journal":{"name":"Journal of clinical gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68153037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LEVEL OF TYPE IV COLLAGEN IN HUMAN PLASMA AS A PREDICTOR OF PRESENCE OF EROSIVE ESOPHAGITIS IN PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE","authors":"Y. Shaukovich","doi":"10.21767/2575-7733-c1-012","DOIUrl":"https://doi.org/10.21767/2575-7733-c1-012","url":null,"abstract":"","PeriodicalId":92538,"journal":{"name":"Journal of clinical gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68154300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison of the Liver Fat Score and CT Liver-to-Spleen Ratio as Predictors of Fatty Liver Disease by HIV Serostatus.","authors":"Lauren E Mellor-Crummey,&nbsp;Jordan E Lake,&nbsp;Holly Wilhalme,&nbsp;Chi-Hong Tseng,&nbsp;Philip M Grant,&nbsp;Kristine M Erlandson,&nbsp;Jennifer C Price,&nbsp;Frank J Palella,&nbsp;Larry A Kingsley,&nbsp;Matthew Budoff,&nbsp;Wendy S Post,&nbsp;Todd T Brown","doi":"10.21767/2575-7733.1000045","DOIUrl":"https://doi.org/10.21767/2575-7733.1000045","url":null,"abstract":"<p><strong>Background and aim: </strong>Non-alcoholic fatty liver disease (NAFLD) is common among HIV-infected (HIV+) adults. The Liver Fat Score (LFS) is a non-invasive, rapid, inexpensive diagnostic tool that uses routine clinical data and is validated against biopsy in HIV-uninfected (HIV-) persons. CT liver-to-spleen (L/S) attenuation ratio is another validated method to diagnose NAFLD. We compared NAFLD prevalence using the LFS versus L/S ratio among Multicenter AIDS Cohort Study participants to assess the LFS's performance in HIV+vs. HIV-men.</p><p><strong>Methods: </strong>In a cross-sectional analysis of men reporting<3 alcoholic drinks daily (308 HIV+, 218 HIV-), Spearman correlations determined relationships between LFS and L/S ratio by HIV serostatus. Multivariable regression determined factors associated with discordance in LFS- and L/S ratio-defined NAFLD prevalence.</p><p><strong>Results: </strong>NAFLD prevalence by LFS and L/S ratio were 28%/15% for HIV+men and 20%/19% for HIV-men, respectively. Correlations between LFS and L/S ratio were weaker among HIV+than HIV-men, but improved with increasing BMI and exclusion of HCV-infected men. LFS and L/S ratio discordance occurred more frequently and across BMI strata among HIV+men, but predominantly at BMI<30 kg/m² among HIV-men. In multivariate analysis, only lower total testosterone levels were significantly associated with discordance.</p><p><strong>Conclusion: </strong>NAFLD prevalence was similar by LFS and L/S ratio identification among HIV-men, but dissimilar and with frequent discordance between the two tests among HIV+men. As discordance may be multifactorial, biopsy data are needed to determine the best non-invasive diagnostic test for NAFLD in HIV+persons.</p>","PeriodicalId":92538,"journal":{"name":"Journal of clinical gastroenterology and hepatology","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2575-7733.1000045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36748635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real World Experience of Drug Induced Liver Injury in Patients Undergoing Chemotherapy.","authors":"Adiba Azad,&nbsp;Paul Chang,&nbsp;Deepika Devuni,&nbsp;Kian Bichoupan,&nbsp;Varun Kesar,&nbsp;Andrea D Branch,&nbsp;William K Oh,&nbsp;Matthew D Galsky,&nbsp;Jawad Ahmad,&nbsp;Joseph A Odin","doi":"10.21767/2575-7733.1000047","DOIUrl":"https://doi.org/10.21767/2575-7733.1000047","url":null,"abstract":"<p><strong>Background & aim: </strong>To better understand the clinical significance of drug induced liver injury (DILI) during chemotherapy, we examined the epidemiology, incidence, and treatment effects of DILI in patients undergoing chemotherapy for genitourinary malignancies over a two-year period.</p><p><strong>Methods: </strong>We conducted a retrospective review of 284 patients who underwent chemotherapy for prostate, bladder, testicular and renal cell carcinomas over a two year period. Those with abnormal or absent liver test (LT) results prior to chemotherapy initiation were excluded. Post chemotherapy LT results were defined as DILI if ALT>3× ULN and/or total bilirubin (TB)>2× ULN, in the absence of other more likely causes of elevated LT.</p><p><strong>Results: </strong>The cumulative incidence of DILI in the total study population was 6.1% (17/284), and in the population who had appropriate LT performed it increased to 18.9% (17/90). Chemotherapeutic agents were determined to be the cause of DILI in 82% (14/17) of patients, and the treatment plans were changed in 59% (10/17) of patients.</p><p><strong>Conclusion: </strong>In this real world study, the cumulative incidence of DILI was higher than commonly reported in clinical trials, and the majority of affected patients had to have their cancer treatment altered or interrupted.</p>","PeriodicalId":92538,"journal":{"name":"Journal of clinical gastroenterology and hepatology","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2575-7733.1000047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36847991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}