EC pulmonology and respiratory medicine最新文献

Overview of multi-omics approaches for pulmonary sarcoidosis. 肺结节病多组学治疗方法综述。

EC pulmonology and respiratory medicine Pub Date : 2025-01-01 Epub Date: 2024-12-16

Yifan Fei, Zhe Lei, Yuhong Wang, Macaluso Joshua, Lingchuan Guo, Li Li

{"title":"Overview of multi-omics approaches for pulmonary sarcoidosis.","authors":"Yifan Fei, Zhe Lei, Yuhong Wang, Macaluso Joshua, Lingchuan Guo, Li Li","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: Here, we review recent findings in the transcriptome, proteome, metabolomics, and microbiome of pulmonary sarcoidosis and highlight differentially expressed genes, specific pathways, mechanisms, microorganisms, metabolites, and targeted therapeutics in the field.Recent findings: The transcriptome and proteome of pulmonary sarcoidosis have been widely studied in recent years. Many differentially expressed genes and signaling pathways have been identified. Several proteins have been identified as potential molecular markers of pulmonary sarcoidosis. The microorganisms and metabolites of patients with sarcoidosis also have certain specificity. We compared pulmonary sarcoidosis with other diseases, such as idiopathic pulmonary fibrosis, tuberculosis, and chronic beryllium disease, and found some differential diagnoses. Based on the identified pathways and mechanisms, targeted therapeutic strategies have been proposed.Summary: Many differentially expressed genes have been identified, including CBX8, CCL5, CXCL9, CXCL11, GBP1, GBP5, LINC01278, MMP12, PSMB9, STAT1, and TLE3, as well as the related enriched pathways, such as the IFN-γ, IL-1, IL-17, MHC, T-cell receptor, TNF, Th1, and Th2 signaling pathways. Proteins such as ABCG1, Apo A-I, CXCR5, MMP12, PD-1, PPARγ, and vitamin D-binding protein, together with the Fc galactosylation status of IgG4, are potential molecular markers for pulmonary sarcoidosis. Many specific microorganisms and metabolites in patients with sarcoidosis have also been found. Targeted drugs such as infliximab, nintedanib and rituximab have been proposed according to the discovered pathways and mechanisms.","PeriodicalId":92503,"journal":{"name":"EC pulmonology and respiratory medicine","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Switches between Cancer and Emphysema Resolution of Cigarette-Smoke Induced Inflammation. 癌症与肺气肿之间的基因转换解决香烟烟雾诱发的炎症。

EC pulmonology and respiratory medicine Pub Date : 2019-12-01 Epub Date: 2019-11-01

Sandra Grumelli, Victor Pinto-Plata, Bartolome Celli

{"title":"Genetic Switches between Cancer and Emphysema Resolution of Cigarette-Smoke Induced Inflammation.","authors":"Sandra Grumelli, Victor Pinto-Plata, Bartolome Celli","doi":"","DOIUrl":"","url":null,"abstract":"Cigarette smoke initiates an inflammatory response that has aftermath long after quitting. We segregated former smokers, according to their lung function and their co-founding diseases, in 3 groups: Cancer, Emphysema and COPD. Then we searched for outlier genes in intersections of Venn diagrams where we identified 6 subsets and 23 genes that may be responsible for disease outcome. Genes expressed in the cancer patients with or without emphysema (PPA subset) were BHLH, FPRL2, CD49D, DEADH, NRs4A3, MBLL, GNS, BE675435, ISGF-3, and FLJ23462. Patients with emphysema as co-founding disease, with or without cancer (APP), had only ANXA2 in common. Genes expressed only in non-cancer patients (AAP subset) of COPD group were IL-1A, SOX13, RPP38; TBXA2R, NPEPL1, CFLAR, TFEB, PRKCBP1, IGF1R, DDX11, and KCNAB1. HIV-1Rev was the gene expressed in cancer patients with emphysema (APA subset). Then, we also looked at out-layers genes significantly expressed in all patients (PPP subset with 5066 genes), the down-regulated in Emphysema were MMP9, PLUNC, CEACAM5, and NR4A1 while the up-regulated were F2R, COL15A1, PDE4C, and BGN. We chose genes and checked them at the protein level on immune cells, this showed that neutrophils from Cancer group had increased expression of CD49d, and their total number was also increased in bronchial-alveolar lavage (154%). Macrophages in the lung of patients with emphysema were associated with a significant increase of adhesion molecule CD58 and to significant CD95 decrease, indicating they do not die. Besides, macrophages downregulated MMP9 in the lung compared to blood macrophages. Overall, we find that cancer progression requires a stickier and greater number of neutrophils in the lung while emphysema requires stickier and longevous macrophages to lead matrix destruction, and together with higher expression of SOX13 and RPP38, may promote autoimmunity. We also identified two genes, ANXA2 and HIV1-rev, that may be a pivot between cancer and emphysema outcome of inflammation.","PeriodicalId":92503,"journal":{"name":"EC pulmonology and respiratory medicine","volume":"8 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138815608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cultural and Environmental Enablers and Barriers to Participation and Retention in Clinical Trials for Cancer Research. 参与和保留癌症临床试验的文化和环境因素和障碍。

EC pulmonology and respiratory medicine Pub Date : 2019-09-01 Epub Date: 2019-08-16

Trisha Petitte, Allison Nichols, Georgia Narsavage

{"title":"Cultural and Environmental Enablers and Barriers to Participation and Retention in Clinical Trials for Cancer Research.","authors":"Trisha Petitte, Allison Nichols, Georgia Narsavage","doi":"","DOIUrl":"","url":null,"abstract":"Background: West Virginia (WV) residents have often rejected participation in community-based cancer research studies. Nationally, 49% of eligible patients participate in clinical trials but less than 10% of patients in WV participate.Objective: To understand issues related to recruitment and retention of patients for cancer research in Appalachian WV.Methods: Data were obtained from 3 focus groups including: (1) 9 patients who participated in clinical cancer trials, (2) 8 cancer research nurse coordinators, and (3) 10 physicians involved in cancer research. Groups were audio-taped and transcriptions were analyzed using MAXQDA and results were verified by two co-investigators.Results: Most enablers and barriers identified were cultural as indicated by 72% of patients; 68% nurse coordinators; and 55% physicians. Patients identified personal emotional strength as an enabler, and negative health behaviors and fears as barriers. Enablers that nurses identified were positive patient characteristics and barriers included fear of trials, randomization, and death. Physicians identified enablers as a patient's understanding of the clinical trial and motivation to help others and the inverse of these two enablers as barriers.Conclusion: A foundation for improving recruitment and retention of participants in cancer research in Appalachia was identified. The next step will involve cancer community organizations and patients in developing a plan to enhance enablers and overcome barriers to patient recruitment in cancer studies.Implications for practice: Cultural influences must be considered when recruiting for clinical trials. Community organizations educating the public about cancer research may be the key to enhancing patient enrollment.","PeriodicalId":92503,"journal":{"name":"EC pulmonology and respiratory medicine","volume":"8 9","pages":"600-606"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034422/pdf/nihms-1066314.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37670926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012. 40-79 岁成年人自述慢性阻塞性肺病的患病率及相关因素：2007-2012 年全国健康与营养调查 (NHANES)。

EC pulmonology and respiratory medicine Pub Date : 2018-01-01 Epub Date: 2018-08-28

Timothy Tilert, Ryne Paulose-Ram, Donna Howard, James Butler, Sunmin Lee, Min Qi Wang

{"title":"Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.","authors":"Timothy Tilert, Ryne Paulose-Ram, Donna Howard, James Butler, Sunmin Lee, Min Qi Wang","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Chronic obstructive pulmonary disease (COPD) is a respiratory disease that often goes undiagnosed, particularly in its early stages.Objective: To examine sociodemographic, general health, and COPD specific factors, including severity of lung obstruction, that are associated with healthcare provider-diagnosed COPD among U.S. adults.Methods: NHANES cross-sectional data collected from 2007-2012 on adults aged 40-79 years (n=10,219) were analyzed. The primary outcome was self-reported COPD diagnosis with predictive factors analyzed via chi-square and logistic regression analyses.Results: During 2007-2012, 5.2% of US adults aged 40-79 reported being diagnosed with COPD. Among those diagnosed, 50.8% reported fair or poor health, 47.1% were currently smoking cigarettes, 49.1% were taking prescription respiratory medication, 36.4% had moderate or worse lung obstruction, and nearly 90% had one or more respiratory symptoms. Logistic regression revealed positive associations between receiving a COPD diagnosis and the following: being white (AOR: 3.08, 95% CI: 1.82-5.20); being aged 60-79 years (AOR: 1.65, 95% CI: 1.07-2.53); reporting fair/poor health (AOR: 2.91, CI: 1.55-5.46); having 4-9 (AOR: 3.5, CI: 1.3-9.4) or 10 or more healthcare visits in prior year (AOR: 5.06, CI: 1.62-15.77); being a former (AOR: 1.75, CI: 1.2-2.5) or current smoker (AOR: 1.70, CI: 1.17-2.48); having more severe lung obstruction (AOR: 4.90, CI: 3.28-7.32); having 3 or more respiratory symptoms (AOR: 22.07, CI: 12.03-40.49).Conclusions: Multiple factors are associated with self-reported COPD diagnosis with number of reported respiratory symptoms having the strongest association. After controlling for other factors, having mild lung obstruction was not associated with being diagnosed.","PeriodicalId":92503,"journal":{"name":"EC pulmonology and respiratory medicine","volume":"7 9","pages":"650-662"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169793/pdf/nihms-987933.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36553706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0