{"title":"Topics in Anti-Cancer Research: Volume 8","authors":"","doi":"10.2174/97898114043821190801","DOIUrl":"https://doi.org/10.2174/97898114043821190801","url":null,"abstract":"Topics in Anti-Cancer Research covers new developments in the field of cancer. Novel\u0000drugs as anticancer agents include natural and synthetic phenazines and other anti-cancer\u0000compounds. It also encompasses the role of estrogen as endocrine disruptors and strategies\u0000targeting cancer stem cells for the treatment of different types of cancers, including myeloma\u0000and renal cell cancer.\u0000The diversity of researches and topics published in this eBook Series will be valuable to\u0000cancer researchers, clinicians, and cancer professionals aiming to develop novel anti-cancer\u0000targets for the treatment of various cancers.\u0000The topics covered in the eighth volume of this series are as follows:\u0000Novel Drugs for Multiple Myeloma\u0000Synthetic Estrogens are Endocrine Disruptors via Inhibition of AF1 Domain of ERs\u0000Recent Progress of Phenazines as Anticancer Agents\u0000Cancer Stem Cell Targeting for Anticancer Therapy: Strategies and Challenges","PeriodicalId":92461,"journal":{"name":"Topics in anti-cancer research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45849462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advances in Anti-Cancer Drug Development Targeting Carbonic Anhydrase IX and XII.","authors":"Mam Y Mboge, Robert McKenna, Susan C Frost","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The microenvironment within a solid tumor is heterogeneous with regions being both acidic and hypoxic. As a result of this, cancer cells upregulate genes that allow survival in such environments. Some of these genes are pH regulatory factors, including carbonic anhydrase IX (CA IX) and in some cases XII (CA XII). CA IX helps to maintain normal cytoplasmic pH (pHi) while simultaneously contributing to the extracellular pH (pHe). CA XII is also thought to be responsible for stabilizing pHe at physiological conditions. Extracellular acidification of the tumor microenvironment promotes local invasion and metastasis while decreasing the effectiveness of adjuvant therapies, thus contributing to poor cancer clinical outcomes. In this review, we describe the properties of CA IX and CA XII that substantiate their potential use as anticancer targets. We also discuss the current status of CA isoform-selective inhibitor development and patents of CA IX/XII targeted inhibitors that show potential for treating aggressive tumors. Some of the recently published patents discussed include sulfonamide-based small molecule inhibitors including derivatives of boron cluster compounds; metal complexes of poly(carboxyl)amine-containing ligands; nitroi-midazole-, ureidosulfonamide-, and coumarin-based compounds; as well as G250 and A610 monoclonal antibodies for cancer treatment.</p>","PeriodicalId":92461,"journal":{"name":"Topics in anti-cancer research","volume":"5 ","pages":"3-42"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162069/pdf/nihms945160.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36539731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
求助内容：
应助结果提醒方式：