发布求助
文献互助 智能选刊 最新文献

Journal of translational neurosciences最新文献

筛选
英文 中文
Urokinase-type Plasminogen Activator Promotes Synaptic Recovery in the Ischemic Brain. 尿激酶型纤溶酶原激活剂促进缺血性脑突触恢复。
Journal of translational neurosciences Pub Date : 2018-01-01 Epub Date: 2018-03-20
Manuel Yepes
{"title":"Urokinase-type Plasminogen Activator Promotes Synaptic Recovery in the Ischemic Brain.","authors":"Manuel Yepes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Synaptic dysfunction underlies the development of neurological impairment following an acute ischemic stroke. Unfortunately, to this date there is no therapeutic approach to protect and repair the synapse that has suffered an ischemic injury. However, recent research with <i>in vitro</i> models of hypoxia, <i>in vivo</i> models of cerebral ischemia and different neuroradiological techniques has revealed that during the recovery phase from a hypoxic injury neurons release the serine proteinase urokinase-type plasminogen activator (uPA) and astrocytes recruit its receptor (uPAR) to their plasma membrane; and that binding of neuronal uPA to astrocytic uPAR promotes the recovery of the \"tripartite synapse\" that has suffered an acute ischemic injury. The translational relevance of these findings is underscored by the fact that intravenous treatment with recombinant uPA promotes synaptic recovery and functional improvement following an acute ischemic stroke.</p>","PeriodicalId":92420,"journal":{"name":"Journal of translational neurosciences","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36253689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信