{"title":"Extensive Dermatosis Neglecta with Severe Atopic Dermatitis: A Case that Presented as a Suicide Attempt","authors":"R. Yoshinaga, Y. Goto, E. Tahara","doi":"10.15761/GOD.1000227","DOIUrl":"https://doi.org/10.15761/GOD.1000227","url":null,"abstract":"In this report, we present a case of extensive dermatosis neglecta with severe atopic dermatitis which presented as a suicide attempt. A 19-year-old woman was admitted for a suicide attempt by drug overdose. Her body was almost entirely covered by dark brown plaque. During her recovery, she reported dermatological pain and hyperesthesia. She had suffered from atopic dermatitis (AD) since her childhood. She had stopped topical steroid therapy (TST) for fears of the side effects since becoming a teenager. She became socially withdrawn due to worsening AD and felt depressive. She had not bathed or showered for seven years and the plaque had developed over two years. She was diagnosed with depression and dermatosis neglecta with severe AD. She had emotional instability and strongly refused to receive TST. We started counselling from a psychiatrist and a Japanese traditional herbal (Kampo) medicine, Shofusan for her skin, which became a stepping-stone to undertaking and restarting TST. Her mental and dermatological conditions gradually improved. She continued these therapies as an outpatient. One year and ten months later, her skin had almost fully recovered, and she remained healthy. This case shows that severe AD and a misunderstanding of TST could contribute to extensive dermatosis neglecta. Comprehensive and integrated care was useful for the patient, who had depression with suicidal ideation and steroid phobia.","PeriodicalId":92366,"journal":{"name":"Global dermatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67466553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Issoual, I. Louizi, S. Dahhouki, S. Gallouj, S. Ellloudi, Z. Douhi, H. Baybay, Mernissi Fz
{"title":"A rare case of onychomycosis induced by Alternaria alternata","authors":"K. Issoual, I. Louizi, S. Dahhouki, S. Gallouj, S. Ellloudi, Z. Douhi, H. Baybay, Mernissi Fz","doi":"10.15761/GOD.1000223","DOIUrl":"https://doi.org/10.15761/GOD.1000223","url":null,"abstract":"Alternaria is the rarest NDM, it represents 0.08% to 2.5% of all onychomycosis and 3 to 10% of NDM; These infections have no characteristic clinical signs, but they are known by their sensitivity to itraconazole, voriconazole and posaconazole, resistance to griseofulvin, 5-flucytosine and fluconazole, and discreet sensitivity to ketoconazole (Figure 1). A rare case of onychomycosis induced by Alternaria alternata","PeriodicalId":92366,"journal":{"name":"Global dermatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67466326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nits of Louse on the hairs of Holy Maria-Magdalena: a SEM-EDX study","authors":"G. Lucotte, Areki Izri, T. Thomasset","doi":"10.15761/GOD.1000228","DOIUrl":"https://doi.org/10.15761/GOD.1000228","url":null,"abstract":"Background: Presence of nits of louse on the hairs of potential Holy Maria-Magdalena. Objective: Electron microscopic studies of the hairs, to find nits on the hair surfaces. Methods: SEM-EDX studies of ten conserved hairs. Results: The results show five microscopic features characteristic of nits, each spreading out on different hairs; embryos can be distinguished in four eggs on five. These","PeriodicalId":92366,"journal":{"name":"Global dermatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67466212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of iontophoresis with growth factor cocktail containing fibroblast growth factor 5-short applied to the scalp in patients with androgenetic alopecia - A split study","authors":"B. Ro, Sung Min Kim, Jaewoo Kang, Hang-Cheol Shin","doi":"10.15761/GOD.1000225","DOIUrl":"https://doi.org/10.15761/GOD.1000225","url":null,"abstract":"Background: Growth factor cocktail (GFC) in combination with microneedling is an effective and safe treatment for patients with androgenetic alopecia (AGA). However, few studies have been conducted on the absorption of GFC into the scalp through iontophoresis. Objective: The aim of this study was to evaluate the effect of iontophoresis with GFC, including fibroblast growth factor 5-short (FGF5s), on hair growth in AGA patients. Methods: The study was performed on AGA patients who were treated with a topical solution and iontophoresis once per day for 24 weeks. The scalp was divided into right and left sides, and treated with GFC including FGF5s (right side) and normal saline (left side). Iontophoresis was performed on the scalp using the headset for 15 min daily. In total, 21 patients (10 men and 11 women) were enrolled. Treatment efficacy was evaluated through analyses of phototrichograms and digital photographs every 4 weeks for 24 weeks. Results: Phototrichogram images showed that 24 weeks of treatment with GFC including FGF5s with iontophoresis increased hair density from 179.2±5.5/cm 2 to 193.9 ±5.3/cm 2 ( p< 0.0001) and hair diameter from 54.9±2.3 µm to 55.3±2.3 µm ( p< 0.0565). The phototrichogram images of the region treated with saline after 24 weeks were not significantly different from baseline in hair density. Conclusion: Absorption of GFC including FGF5s following iontophoresis was effective for patients with AGA in a time frame of 12 weeks. However, further study is needed on the long term efficacy of absorption of GFC through iontophoresis.","PeriodicalId":92366,"journal":{"name":"Global dermatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67466385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Laamari, H. Baybay, Chaymae Jroundi, Z. Douhi, S. Elloudi, F. Mernissi
{"title":"Multiple angiokeratomas of fordyce","authors":"K. Laamari, H. Baybay, Chaymae Jroundi, Z. Douhi, S. Elloudi, F. Mernissi","doi":"10.15761/GOD.1000226","DOIUrl":"https://doi.org/10.15761/GOD.1000226","url":null,"abstract":"Angiokeratomas are rare benign vascular lesions characterized by dilated thin-walled blood vessels lying in the upper part of the dermis, mostly associated with an epidermal reaction such as acanthosis and/or hyperkeratosis. Angiokeratomas of Fordyce are predominantly located on the scrotum and are only rarely found on the penis. We report two cases of angiokeratoma of Fordyce located on the glans penis.","PeriodicalId":92366,"journal":{"name":"Global dermatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67466503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Common genetic hair shaft abnormalities may be visualized by light and electron microscope","authors":"Saad R Abed","doi":"10.15761/god.1000221","DOIUrl":"https://doi.org/10.15761/god.1000221","url":null,"abstract":"","PeriodicalId":92366,"journal":{"name":"Global dermatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67466269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Proteomics and melanoma: a current perspective.","authors":"Bradley D Shields, Alan J Tackett, Sara C Shalin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Proteomics is the study of the protein complement of the genome, and this powerful technique complements genomic studies. Proteomic experiments result in the generation of large volumes of data requiring complicated analysis algorithms and subsequent confirmatory studies. Until recently, technological limitations of experimental protocols precluded the use of formalin-fixed tissues for these types of studies. Recent advances have allowed the use of valuable archived patient tissue samples in proteomic research, resulting in an opportunity to perform cutting edge translational research. The field of melanoma research stands to benefit greatly from collaboration between dermatopathologists and proteomic scientists. This article seeks to: 1) describe proteomics for dermatologists and pathologists, including the tools used in proteomic research, and 2) convey a historical account of proteomic studies within the field of melanoma followed by a discussion on how recent advances are informing current studies.</p>","PeriodicalId":92366,"journal":{"name":"Global dermatology","volume":"3 4","pages":"366-370"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36491994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}