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Computational Systems Biology Approach for the Study of Rheumatoid Arthritis: From a Molecular Map to a Dynamical Model. 类风湿关节炎研究的计算系统生物学方法：从分子图谱到动态模型。

Genomics and computational biology Pub Date : 2018-01-01 Epub Date: 2017-12-06 DOI: 10.18547/gcb.2018.vol4.iss1.e100050

Vidisha Singh, Marek Ostaszewski, George D Kalliolias, Gilles Chiocchia, Robert Olaso, Elisabeth Petit-Teixeira, Tomáš Helikar, Anna Niarakis

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引用次数: 0

Histone Code and Higher-Order Chromatin Folding: A Hypothesis. 组蛋白编码和高阶染色质折叠:一个假说。

Genomics and computational biology Pub Date : 2017-01-01 Epub Date: 2017-01-30 DOI: 10.18547/gcb.2017.vol3.iss2.e41

Kirti Prakash, David Fournier

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引用次数: 0

Histone Code and Higher-Order Chromatin Folding: A Hypothesis 组蛋白编码和高阶染色质折叠:一个假说

Genomics and computational biology Pub Date : 2016-11-04 DOI: 10.1101/085860

Kirti Prakash, D. Fournier

{"title":"Histone Code and Higher-Order Chromatin Folding: A Hypothesis","authors":"Kirti Prakash, D. Fournier","doi":"10.1101/085860","DOIUrl":"https://doi.org/10.1101/085860","url":null,"abstract":"Histone modifications alone or in combination are thought to modulate chromatin structure and function; a concept termed histone code. By combining evidence from several studies, we investigated if the histone code can play a role in higher-order folding of chromatin. Firstly using genomic data, we analyzed associations between histone modifications at the nucleosome level. We could dissect the composition of individual nucleosomes into five predicted clusters of histone modifications. Secondly, by assembling the raw reads of histone modifications at various length scales, we noticed that the histone mark relationships that exist at nucleosome level tend to be maintained at the higher orders of chromatin folding. Recently, a high-resolution imaging study showed that histone marks belonging to three of the five predicted clusters show structurally distinct and anti-correlated chromatin domains at the level of chromosomes. This made us think that the histone code can have a significant impact in the overall compaction of DNA: at the level of nucleosomes, at the level of genes, and finally at the level of chromosomes. As a result, in this article, we put forward a theory where the histone code drives not only the functionality but also the higher-order folding and compaction of chromatin.","PeriodicalId":92363,"journal":{"name":"Genomics and computational biology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62292462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20