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Infographic: Biomarkers for Liver Disease 信息图:肝病的生物标志物
European medical journal. Hepatology Pub Date : 2023-07-28 DOI: 10.33590/emjhepatol/10307554.
{"title":"Infographic: Biomarkers for Liver Disease","authors":"","doi":"10.33590/emjhepatol/10307554.","DOIUrl":"https://doi.org/10.33590/emjhepatol/10307554.","url":null,"abstract":"","PeriodicalId":92358,"journal":{"name":"European medical journal. Hepatology","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135602890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intrahepatic Splenosis in a Patient with Autoimmune Hepatitis with No History of Splenectomy or Abdominal Trauma 无脾切除术或腹部创伤史的自身免疫性肝炎患者肝内脾亢1例
European medical journal. Hepatology Pub Date : 2023-07-27 DOI: 10.33590/emjhepatol/10307663.
Keiya Aono, Takahiro Suzuki, Masaoki Hattori, Motoi Yoshihara
{"title":"Intrahepatic Splenosis in a Patient with Autoimmune Hepatitis with No History of Splenectomy or Abdominal Trauma","authors":"Keiya Aono, Takahiro Suzuki, Masaoki Hattori, Motoi Yoshihara","doi":"10.33590/emjhepatol/10307663.","DOIUrl":"https://doi.org/10.33590/emjhepatol/10307663.","url":null,"abstract":"Splenosis should be suspected when a patient has a history of trauma or abdominal surgery. Intrahepatic splenosis is a rare disease that is often difficult to distinguish from liver malignancy, especially hepatocellular carcinoma. The cause of intrahepatic splenosis may be though the auto-transplantation of splenic tissue on the surface of the liver. The authors report a case of intrahepatic splenosis that presented as a liver tumour in an 81-year-old female treated for autoimmune hepatitis, who had no history of splenectomy or abdominal trauma. Laparoscopic hepatectomy was performed and the specimen demonstrated characteristic histopathological findings of the spleen. Only one case of a patient who had no history of splenectomy or abdominal trauma has been reported in the literature. It may be hypothesised that erythropoiesis induced by local hypoxia in the chronic hepatitis may cause the growth of splenic erythrocytic progenitor cells, which have migrated via portal vein to the liver.","PeriodicalId":92358,"journal":{"name":"European medical journal. Hepatology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135756293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Difficult Biliary Cannulation in Endoscopic Retrograde Cholangiopancreatography: An Overview of Advanced Techniques 内镜逆行胆管造影中困难的胆道插管:先进技术综述
European medical journal. Hepatology Pub Date : 2021-08-01 DOI: 10.33590/emjhepatol/21-00005
Brian M. Fung, T. Pitea, J. Tabibian
{"title":"Difficult Biliary Cannulation in Endoscopic Retrograde Cholangiopancreatography: An Overview of Advanced Techniques","authors":"Brian M. Fung, T. Pitea, J. Tabibian","doi":"10.33590/emjhepatol/21-00005","DOIUrl":"https://doi.org/10.33590/emjhepatol/21-00005","url":null,"abstract":"Endoscopic retrograde cholangiopancreatography (ERCP) plays a significant role in the treatment of a vast array of pancreatobiliary diseases. However, despite significant progress in the optimisation of ERCP methods and accessories, the technical and clinical success of ERCP can vary significantly due to a variety of patient and operator factors. Over the past several decades, a number of advanced techniques have been developed to improve cannulation success rates, including the use of double-guidewire, pancreatic duct accessory-assisted, precut, and rendezvous techniques. Here, the authors provide an update and overview of the existing advanced techniques used in cases of difficult biliary cannulation, as well as the approach to their selection.","PeriodicalId":92358,"journal":{"name":"European medical journal. Hepatology","volume":"126 1","pages":"73 - 82"},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76223759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Difficult Biliary Cannulation in Endoscopic Retrograde Cholangiopancreatography: Definitions, Risk Factors, and Implications. 内镜逆行胆管造影术中胆道插管困难:定义、危险因素和影响。
European medical journal. Hepatology Pub Date : 2021-08-01 Epub Date: 2021-08-05
Brian M Fung, Teodor C Pitea, James H Tabibian
{"title":"Difficult Biliary Cannulation in Endoscopic Retrograde Cholangiopancreatography: Definitions, Risk Factors, and Implications.","authors":"Brian M Fung,&nbsp;Teodor C Pitea,&nbsp;James H Tabibian","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Over the past 50 years, endoscopic retrograde cholangiopancreatography (ERCP) has become the preferred minimally invasive method of treating a vast array of pancreatobiliary diseases. An initial <i>sine qua non</i> for ERCP success is selective ductal cannulation. Despite significant progress in the optimisation of ERCP methods and accessories, selective biliary cannulation using conventional techniques remains unsuccessful in approximately 15% of native papilla cases. Furthermore, difficult biliary cannulation has been associated with an increased risk of post-ERCP pancreatitis, among other adverse events. Here, in the first of a two-part series, the authors provide a primer on standard biliary cannulation techniques and discuss the definition, risk factors, and implications of difficult biliary cannulation. The second part of the series will provide an overview of the existing advanced techniques used in cases of difficult biliary cannulation as well as the approach to their selection.</p>","PeriodicalId":92358,"journal":{"name":"European medical journal. Hepatology","volume":"9 1","pages":"64-72"},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494185/pdf/nihms-1738650.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39496137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Difficult Biliary Cannulation in Endoscopic Retrograde Cholangiopancreatography: Definitions, Risk Factors, and Implications. 内镜逆行胆管造影术中胆道插管困难:定义、危险因素和影响。
European medical journal. Hepatology Pub Date : 2021-08-01 DOI: 10.33590/emjhepatol/20-00283
Brian M. Fung, T. Pitea, J. Tabibian
{"title":"Difficult Biliary Cannulation in Endoscopic Retrograde Cholangiopancreatography: Definitions, Risk Factors, and Implications.","authors":"Brian M. Fung, T. Pitea, J. Tabibian","doi":"10.33590/emjhepatol/20-00283","DOIUrl":"https://doi.org/10.33590/emjhepatol/20-00283","url":null,"abstract":"Over the past 50 years, endoscopic retrograde cholangiopancreatography (ERCP) has become the preferred minimally invasive method of treating a vast array of pancreatobiliary diseases. An initial sine qua non for ERCP success is selective ductal cannulation. Despite significant progress in the optimisation of ERCP methods and accessories, selective biliary cannulation using conventional techniques remains unsuccessful in approximately 15% of native papilla cases. Furthermore, difficult biliary cannulation has been associated with an increased risk of post-ERCP pancreatitis, among other adverse events. Here, in the first of a two-part series, the authors provide a primer on standard biliary cannulation techniques and discuss the definition, risk factors, and implications of difficult biliary cannulation. The second part of the series will provide an overview of the existing advanced techniques used in cases of difficult biliary cannulation as well as the approach to their selection.","PeriodicalId":92358,"journal":{"name":"European medical journal. Hepatology","volume":"16 1","pages":"64-72"},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83948881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Difficult Biliary Cannulation in Endoscopic Retrograde Cholangiopancreatography: An Overview of Advanced Techniques. 内镜逆行胆管造影中困难的胆道插管:先进技术综述。
European medical journal. Hepatology Pub Date : 2021-08-01 Epub Date: 2021-08-05
Brian M Fung, Teodor C Pitea, James H Tabibian
{"title":"Difficult Biliary Cannulation in Endoscopic Retrograde Cholangiopancreatography: An Overview of Advanced Techniques.","authors":"Brian M Fung,&nbsp;Teodor C Pitea,&nbsp;James H Tabibian","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Endoscopic retrograde cholangiopancreatography (ERCP) plays a significant role in the treatment of a vast array of pancreatobiliary diseases. However, despite significant progress in the optimisation of ERCP methods and accessories, the technical and clinical success of ERCP can vary significantly due to a variety of patient and operator factors. Over the past several decades, a number of advanced techniques have been developed to improve cannulation success rates, including the use of double-guidewire, pancreatic duct accessory-assisted, precut, and rendezvous techniques. Here, the authors provide an update and overview of the existing advanced techniques used in cases of difficult biliary cannulation, as well as the approach to their selection.</p>","PeriodicalId":92358,"journal":{"name":"European medical journal. Hepatology","volume":"9 1","pages":"73-82"},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/31/nihms-1738653.PMC8494186.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39496138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholangioscopy and its Role in Primary Sclerosing Cholangitis. 胆管镜检查及其在原发性硬化性胆管炎中的作用。
European medical journal. Hepatology Pub Date : 2020-06-01 Epub Date: 2020-06-04
Brian M Fung, M Phillip Fejleh, Sooraj Tejaswi, James H Tabibian
{"title":"Cholangioscopy and its Role in Primary Sclerosing Cholangitis.","authors":"Brian M Fung,&nbsp;M Phillip Fejleh,&nbsp;Sooraj Tejaswi,&nbsp;James H Tabibian","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Primary sclerosing cholangitis (PSC) is a cholestatic liver disease characterised by chronic inflammation and fibro-obliteration of the intrahepatic and/or extrahepatic bile ducts. It is associated with numerous hepatobiliary complications including an increased risk of malignancy (in particular, cholangiocarcinoma) and biliary tract stone formation. The evaluation of biliary strictures in patients with PSC is especially challenging, with imaging and endoscopic methods having only modest sensitivity for the diagnosis of cholangiocarcinoma, and treatment of biliary strictures poses a similarly significant clinical challenge. In recent years, peroral cholangioscopy has evolved technologically and increased in popularity as an endoscopic tool that can provide direct intraductal visualisation and facilitate therapeutic manipulation of the biliary tract. However, the indications for and effectiveness of its use in patients with PSC remain uncertain, with only a few studies performed on this small but important subset of patients. In this review, the authors discuss the available data regarding the use of peroral cholangioscopy in patients with PSC, with a focus on its use in the evaluation and management of biliary strictures and stones.</p>","PeriodicalId":92358,"journal":{"name":"European medical journal. Hepatology","volume":"8 1","pages":"42-53"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380688/pdf/nihms-1601199.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38203179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe? 巨噬细胞在非酒精性脂肪性肝炎中的作用:是敌是友?
European medical journal. Hepatology Pub Date : 2018-05-31 DOI: 10.33590/emjhepatol/10312252
Joel Grunhut, Wei Wang, B. Aykut, I. Gakhal, Alejandro Torres‐Hernandez, G. Miller
{"title":"Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe?","authors":"Joel Grunhut, Wei Wang, B. Aykut, I. Gakhal, Alejandro Torres‐Hernandez, G. Miller","doi":"10.33590/emjhepatol/10312252","DOIUrl":"https://doi.org/10.33590/emjhepatol/10312252","url":null,"abstract":"Nonalcoholic steatohepatitis (NASH) is a subtype of nonalcoholic fatty liver disease that is characterised by steatosis, chronic inflammation, and hepatocellular injury with or without fibrosis. The role and activation of macrophages in the pathogenesis of NASH is complex and is being studied for possible therapeutic options to help the millions of people diagnosed with the disease. The purpose of this review is to discuss the pathogenesis of NASH through the activation and role of Kupffer cells and other macrophages in causing inflammation and progression of NASH. Furthermore, this review aims to outline some of the current therapeutic options targeting the pathogenesis of NASH.","PeriodicalId":92358,"journal":{"name":"European medical journal. Hepatology","volume":"24 5 1","pages":"100-109"},"PeriodicalIF":0.0,"publicationDate":"2018-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78048365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
Targeting the Relaxin Pathway for Liver Disease Treatment. 靶向松弛素途径治疗肝病。
European medical journal. Hepatology Pub Date : 2018-05-01 DOI: 10.33590/emjhepatol/10311638
R. Bennett
{"title":"Targeting the Relaxin Pathway for Liver Disease Treatment.","authors":"R. Bennett","doi":"10.33590/emjhepatol/10311638","DOIUrl":"https://doi.org/10.33590/emjhepatol/10311638","url":null,"abstract":"Hepatic fibrosis is a progressive disease with few treatment options outside of transplantation. Relaxin is a member of the insulin/relaxin superfamily of peptide hormones. Originally known for its roles in pregnancy, relaxin promotes reproductive tissue remodelling and regulates vascular changes, including increased arterial compliance and reduced vascular resistance. Outside of pregnancy, relaxin plays a major role in the protection of organs from excess extracellular matrix accumulation, as demonstrated by the relaxin-null mouse, which develops widespread fibrosis with ageing. Relaxin reduces scarring due to excess collagen deposition by inhibiting collagen production while simultaneously promoting its degradation and can reduce established fibrosis in several animal models of extracellular matrix-associated disease, including liver fibrosis. Treatment with relaxin reduces the myofibroblastic phenotype of activated hepatic stellate cells, the major hepatic collagen-producing cell in fibrosis and cirrhosis. Relaxin also has haemodynamic effects, including vasodilation, and can reduce portal hypertension associated with cirrhosis. In this review, a brief overview of hepatic fibrosis and the role of the hepatic stellate cell will be presented, followed by an introduction to relaxin and its actions. The use of relaxin to treat preclinical models of fibrotic diseases, including liver diseases, will also be discussed. Finally, the completed, current, and ongoing clinical trials of relaxin in human disease will be described, followed by the limitations and future directions for the use of relaxin for disease treatment.","PeriodicalId":92358,"journal":{"name":"European medical journal. Hepatology","volume":"13 1","pages":"80-87"},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79742633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe? 巨噬细胞在非酒精性脂肪性肝炎中的作用:是敌是友?
European medical journal. Hepatology Pub Date : 2018-01-01 Epub Date: 2018-05-31
Joel Grunhut, Wei Wang, Berk Aykut, Inderdeep Gakhal, Alejandro Torres-Hernandez, George Miller
{"title":"Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe?","authors":"Joel Grunhut,&nbsp;Wei Wang,&nbsp;Berk Aykut,&nbsp;Inderdeep Gakhal,&nbsp;Alejandro Torres-Hernandez,&nbsp;George Miller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nonalcoholic steatohepatitis (NASH) is a subtype of nonalcoholic fatty liver disease that is characterised by steatosis, chronic inflammation, and hepatocellular injury with or without fibrosis. The role and activation of macrophages in the pathogenesis of NASH is complex and is being studied for possible therapeutic options to help the millions of people diagnosed with the disease. The purpose of this review is to discuss the pathogenesis of NASH through the activation and role of Kupffer cells and other macrophages in causing inflammation and progression of NASH. Furthermore, this review aims to outline some of the current therapeutic options targeting the pathogenesis of NASH.</p>","PeriodicalId":92358,"journal":{"name":"European medical journal. Hepatology","volume":"6 1","pages":"100-109"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007994/pdf/nihms972830.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36247643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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