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American journal of leukemia research最新文献

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High dose cytarabine, mitoxantrone, pegasapargase (HAM-pegA) in combination with dasatinib for the first-line treatment of Philadelphia chromosome positive mixed phenotype acute leukemia. 高剂量阿糖胞苷、米托蒽醌、pegasgasase (HAM-pegA)联合达沙替尼一线治疗费城染色体阳性混合表型急性白血病
American journal of leukemia research Pub Date : 2020-01-01 Epub Date: 2020-10-15
Ciera L Patzke, Ashkan Emadi
{"title":"High dose cytarabine, mitoxantrone, pegasapargase (HAM-pegA) in combination with dasatinib for the first-line treatment of Philadelphia chromosome positive mixed phenotype acute leukemia.","authors":"Ciera L Patzke,&nbsp;Ashkan Emadi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The treatment of mixed phenotype acute leukemia (MPAL) is challenging due to the presence of disease characteristics of both myeloid and lymphoid leukemia. Regimens historically used to treat acute lymphoblastic leukemia are often used to treat MPAL, particularly for patients whose diseases also possess the Philadelphia chromosome (Ph+). Here we present a novel regimen, HAM-pegA plus dasatinib, for the treatment of two patients with newly diagnosed Ph+ MPAL. This regimen is a blend of both myeloid-targeted and lymphoid-targeted chemotherapy agents, and is given as a single cycle of intensive chemotherapy followed by oral dasatinib maintenance therapy. Without proceeding to allogeneic transplant, this regimen produced durable remissions of 18 months and longer. This novel regimen offers an exciting alternative to other intensive regimens that require multiple cycles of intensive chemotherapy and allogeneic transplant in first remission.</p>","PeriodicalId":92326,"journal":{"name":"American journal of leukemia research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717491/pdf/nihms-1649859.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38679219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination of Blinatumomab and Vincristine Sulfate Liposome Injection for Treatment of Relapsed Philadelphia Chromosome Positive B-cell Acute Lymphoblastic Leukemia. 布林纳单抗联合硫酸长春新碱脂质体注射液治疗复发性费城染色体阳性b细胞急性淋巴细胞白血病。
American journal of leukemia research Pub Date : 2018-01-01 Epub Date: 2018-03-23
Michael G McCusker, Firas El Chaer, Alison Duffy, Ashkan Emadi, Vu H Duong
{"title":"Combination of Blinatumomab and Vincristine Sulfate Liposome Injection for Treatment of Relapsed Philadelphia Chromosome Positive B-cell Acute Lymphoblastic Leukemia.","authors":"Michael G McCusker,&nbsp;Firas El Chaer,&nbsp;Alison Duffy,&nbsp;Ashkan Emadi,&nbsp;Vu H Duong","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Relapsed Philadelphia chromosome (Ph) positive Acute Lymphoblastic Leukemia (ALL) is an aggressive lymphoid malignancy with a poor prognosis and no randomized studies demonstrating superiority of any single salvage regimen. We present the case of a 33-year-old woman with relapsed Ph positive precursor (pre) B-cell ALL with rapidly rising peripheral blasts while on blinatumomab monotherapy initially, but ultimately responded with the addition of Vincristine Sulfate Liposome Injection (VSLI). Ponatinib was added later when it became available for the patient, and she ultimately achieved a complete remission. Further study is warranted to explore mechanisms of potential synergy, and the safety and efficacy of the combination of blinatumomab and VSLI.</p>","PeriodicalId":92326,"journal":{"name":"American journal of leukemia research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018018/pdf/nihms966400.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36266153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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