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Liquid Biopsy in the OMICS Era of Tumor Medicine 肿瘤医学组学时代的液体活检
Open access journal of biomedical engineering and its applications Pub Date : 2018-03-07 DOI: 10.32474/OAJBEB.2018.01.000115
Yi Jiang, Denong Wang
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引用次数: 6
Liquid Biopsy in the OMICS Era of Tumor Medicine. 肿瘤医学组学时代的液体活检。
Open access journal of biomedical engineering and its applications Pub Date : 2018-01-01 Epub Date: 2018-03-07
Yi Jiang, Denong Wang
{"title":"Liquid Biopsy in the OMICS Era of Tumor Medicine.","authors":"Yi Jiang,&nbsp;Denong Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Liquid biopsy uses noninvasive blood test to assess tumor heterogeneity and evolution in real time. It looks for tumor components in the blood circulation, such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), to provide tumor-specific information. By detecting multiplex tumor biomarkers, including nucleic acids, proteins, carbohydrates, and other tumor-derived substances, liquid biopsy helps with early tumor diagnosis, tumor evolution monitoring, and prognosis prediction. With the development of high-throughput OMICS tools like carbohydrate microarray and high-speed fiber-optic array scanning technology (FAST scan), it is now practical to identify glycan markers of CTCs and cancer stem cells (CSCs), especially those that are cell-surface exposed and readily accessible for immune recognition and targeting. Potential of this class of biomarkers in tumor subtyping and targeted immunotherapy is yet to be explored.</p>","PeriodicalId":92272,"journal":{"name":"Open access journal of biomedical engineering and its applications","volume":"1 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36033150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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