Journal of pharmaceutical sciences and experimental pharmacology最新文献

筛选

英文中文

Cerebral Autoregulation in Hypertension and Ischemic Stroke: A Mini Review. 高血压和缺血性脑卒中中的脑自动调节:一个小综述。

Journal of pharmaceutical sciences and experimental pharmacology Pub Date : 2017-01-01 Epub Date: 2017-10-27

Shashank Shekhar, Ruen Liu, Olivia K Travis, Richard J Roman, Fan Fan

{"title":"Cerebral Autoregulation in Hypertension and Ischemic Stroke: A Mini Review.","authors":"Shashank Shekhar, Ruen Liu, Olivia K Travis, Richard J Roman, Fan Fan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Aging and chronic hypertension are associated with dysfunction in vascular smooth muscle, endothelial cells, and neurovascular coupling. These dysfunctions induce impaired myogenic response and cerebral autoregulation, which diminish the protection of cerebral arterioles to the cerebral microcirculation from elevated pressure in hypertension. Chronic hypertension promotes cerebral focal ischemia in response to reductions in blood pressure that are often seen in sedentary elderly patients on antihypertensive therapy. Cerebral autoregulatory dysfunction evokes Blood-Brain Barrier (BBB) leakage, allowing the circulating inflammatory factors to infiltrate the brain to activate glia. The impaired cerebral autoregulation-induced inflammatory and ischemic injury could cause neuronal cell death and synaptic dysfunction which promote cognitive deficits. In this brief review, we summarize the pathogenesis and signaling mechanisms of cerebral autoregulation in hypertension and ischemic stroke-induced cognitive deficits, and discuss our new targets including 20-Hydroxyeicosatetraenoic acid (20-HETE), Gamma-Adducin (Add3) and Matrix Metalloproteinase-9 (MMP-9) that may contribute to the altered cerebral vascular function.</p>","PeriodicalId":92254,"journal":{"name":"Journal of pharmaceutical sciences and experimental pharmacology","volume":"2017 1","pages":"21-27"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765762/pdf/nihms919276.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35736551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral Autoregulation in Hypertension and Ischemic Stroke: A Mini Review. 高血压和缺血性脑卒中中的脑自动调节:一个小综述。

Journal of pharmaceutical sciences and experimental pharmacology Pub Date : 2017-01-01 DOI: 10.29199/psep.101013

S. Shekhar, Ruen Liu, Olivia K. Travis, R. Roman, Fan Fan

{"title":"Cerebral Autoregulation in Hypertension and Ischemic Stroke: A Mini Review.","authors":"S. Shekhar, Ruen Liu, Olivia K. Travis, R. Roman, Fan Fan","doi":"10.29199/psep.101013","DOIUrl":"https://doi.org/10.29199/psep.101013","url":null,"abstract":"Aging and chronic hypertension are associated with dysfunction in vascular smooth muscle, endothelial cells, and neurovascular coupling. These dysfunctions induce impaired myogenic response and cerebral autoregulation, which diminish the protection of cerebral arterioles to the cerebral microcirculation from elevated pressure in hypertension. Chronic hypertension promotes cerebral focal ischemia in response to reductions in blood pressure that are often seen in sedentary elderly patients on antihypertensive therapy. Cerebral autoregulatory dysfunction evokes Blood-Brain Barrier (BBB) leakage, allowing the circulating inflammatory factors to infiltrate the brain to activate glia. The impaired cerebral autoregulation-induced inflammatory and ischemic injury could cause neuronal cell death and synaptic dysfunction which promote cognitive deficits. In this brief review, we summarize the pathogenesis and signaling mechanisms of cerebral autoregulation in hypertension and ischemic stroke-induced cognitive deficits, and discuss our new targets including 20-Hydroxyeicosatetraenoic acid (20-HETE), Gamma-Adducin (Add3) and Matrix Metalloproteinase-9 (MMP-9) that may contribute to the altered cerebral vascular function.","PeriodicalId":92254,"journal":{"name":"Journal of pharmaceutical sciences and experimental pharmacology","volume":"122 1","pages":"21-27"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90864873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 58