{"title":"Resting-Exercise Salivary Cortisol Responses: Detecting the Magnitude of Hormonal Change Over Time.","authors":"Anthony C Hackney, Travis Anderson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study investigated the validity of salivary cortisol responses to reflect blood cortisol responses relative to the magnitude of change observed over time in the hormone. Male subjects (n=25) conducted four experimental sessions (ES) where blood (B) and saliva (S) were obtained before (PS) and after (PoS) a 30 min resting control, 40%, 60%, and 80% of maximal aerobic capacity (VO2max) exercise ES. B and S specimens were analyzed by standard biochemical procedures. Hormonal concentrations changes were assessed by using absolute delta (DA) values (PoS - PS) and percent change (PC) calculations ((PoS-PS)/PS × 100) for each B and S specimen. Subsequent DA and PC values were correlated (Pearson) for each B-S specimen pairing (n=100; n=25 × 4 ES). Results indicate the magnitude of change (PoS vs. PS) in S cortisol is more valid and strongly associated (p<0.001) with corresponding B changes (the \"gold standard\") when expressing the data as delta values using absolute hormonal concentrations as compared to percent change expression.</p>","PeriodicalId":92234,"journal":{"name":"Journal of clinical and molecular endocrinology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36007938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}