Research & reviews. Journal of hospital and clinical pharmacy最新文献

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Immune Check Point Inhibitors in Cancer Therapy: Beware of "Friendly Fire" Effect. 癌症治疗中的免疫检查点抑制剂:小心“友军火力”效应。
Research & reviews. Journal of hospital and clinical pharmacy Pub Date : 2017-07-01 Epub Date: 2017-06-08
Anuhya Kommalapati, Shanaz Sikder, Sri Harsha Tella
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引用次数: 0
Impact of Norepinephrine Shortage on Outcomes in Patients with Septic Shock. 去甲肾上腺素缺乏对感染性休克患者预后的影响。
Research & reviews. Journal of hospital and clinical pharmacy Pub Date : 2016-05-01 Epub Date: 2016-05-12
Jean M Nappi, Adam Sieg, Tanna B Hassig, Amy E Wahlquist
{"title":"Impact of Norepinephrine Shortage on Outcomes in Patients with Septic Shock.","authors":"Jean M Nappi,&nbsp;Adam Sieg,&nbsp;Tanna B Hassig,&nbsp;Amy E Wahlquist","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>With the previous norepinephrine shortage, alternative agents were required to treat patients with septic shock. This retrospective study evaluated whether the shortage of norepinephrine had an adverse effect on patients admitted to the intensive care unit with a diagnosis of severe sepsis or septic shock.</p><p><strong>Methods: </strong>This was a retrospective chart review, which compared patients who received norepinephrine versus those who did not. Eligible patients were those ≥ 18 years old who were admitted to an intensive care unit with a diagnosis of sepsis and were initiated on a vasopressor to maintain hemodynamic stability. The specific primary endpoint was whether using norepinephrine versus other vasopressors had an effect on ICU length of stay. Secondary outcomes included mortality, blood pressure, mean arterial pressure, development of renal insufficiency, and vasopressor requirements.</p><p><strong>Results: </strong>There were 288 patients screened and 214 patients who met the inclusion criteria (norepinephrine group=106 and nonnorepinephrine group=108). After accounting for potential differences in disease severity (APACHE II score), age, weight and gender, there was no difference in ICU length of stay (p=0.4); however, the odds of survival were 5.9 (95% CI: 3.1 to 11.1) times higher for those in the non-norepinephrine group (p<0.0001).</p><p><strong>Conclusion: </strong>Based on this retrospective analysis, patients that did not receive norepinephrine had a similar ICU LOS but had a higher rate of survival. The norepinephrine shortage did not have an adverse effect on patient outcomes.</p>","PeriodicalId":92132,"journal":{"name":"Research & reviews. Journal of hospital and clinical pharmacy","volume":"2 2","pages":"87-91"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553972/pdf/nihms882306.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35265203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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