Medical case reports (Wilmington, Del.)最新文献

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Durable Response to Letrozole in a Patient with Relapsed Low Grade Endometrial Stromal Sarcoma Metastatic to the Lung - A Case Report 来曲唑治疗转移至肺部的复发性低级别子宫内膜间质肉瘤的持久疗效- 1例报告
Medical case reports (Wilmington, Del.) Pub Date : 2019-01-01 DOI: 10.36648/2471-8041.5.3.127
S. Salah, Yacob Saleh, M. Zmaily, O. Jaber
{"title":"Durable Response to Letrozole in a Patient with Relapsed Low Grade Endometrial Stromal Sarcoma Metastatic to the Lung - A Case Report","authors":"S. Salah, Yacob Saleh, M. Zmaily, O. Jaber","doi":"10.36648/2471-8041.5.3.127","DOIUrl":"https://doi.org/10.36648/2471-8041.5.3.127","url":null,"abstract":"Low Grade Endometrial Stromal Sarcomas (LGESS) are rare uterine neoplasms, with high propensity for local recurrence and an indolent course. Distant metastasis is rare. Hormonal therapy with progestin or aromatase inhibitors has been used successfully to treat relapsed and unresectable disease. We report a 55-year-old female patient with relapsed LGESS in the lungs, who achieved almost complete response to letrozole for more than 6 years. To our knowledge, this is the longest reported durable response with letrozole in patients with LGESS and lung metastasis.","PeriodicalId":92099,"journal":{"name":"Medical case reports (Wilmington, Del.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.36648/2471-8041.5.3.127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69703834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-Resolving Lung Infiltrate: A Rare Case of Papillary Adenocarcinoma of the Lung 不溶解性肺浸润:一例罕见的肺乳头状腺癌
Medical case reports (Wilmington, Del.) Pub Date : 2019-01-01 DOI: 10.36648/2471-8041.5.3.128
N. Madan, C. Escobar, V. Patel
{"title":"Non-Resolving Lung Infiltrate: A Rare Case of Papillary Adenocarcinoma of the Lung","authors":"N. Madan, C. Escobar, V. Patel","doi":"10.36648/2471-8041.5.3.128","DOIUrl":"https://doi.org/10.36648/2471-8041.5.3.128","url":null,"abstract":"Lung carcinoma is one of most common and leading cause of cancer related mortality in United States. The main sub-types of lung cancer are non-small cell lung carcinoma (NSCLC) and small cell carcinoma (SCLC). About 85% of lung cancers are of the non-small cell type, of which more than 50% are adenocarcinomas. Primary papillary adenocarcinoma (PA) is a subtype of adenocarcinoma with predominance of papillary structures that replace the underlying alveolar architecture supported by fibro-vascular cores with complicated secondary and tertiary branches. PA is a relatively rare type that can present a diagnostic challenge when it presents as a non-resolving infilitrate as seen in this case. It is more common in woman and non-smokers. The subtype of adenocarcinoma is key factor for therapeutic choice of chemotherapy. The case reviewed here is a rare presentation of a middle aged chronic smoker Man with past medical history of chronic obstructive pulmonary disease (COPD) who was treated several times for recurrent episodes of worsening dyspnea attributed to an infectious etiology, but without any significant improvement which led to further testing and trans-bronchial biopsy which reveled PA of the lung. Tissue diagnosis is therefore warranted in patients with a non-resolving lung infiltrate.","PeriodicalId":92099,"journal":{"name":"Medical case reports (Wilmington, Del.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.36648/2471-8041.5.3.128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69703846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Acute Liver Failure Induced by Joss Paper Ingestion. 误食香纸引发急性肝衰竭
Medical case reports (Wilmington, Del.) Pub Date : 2019-01-01 Epub Date: 2019-04-30
Barathi Sivasailam, Avnee Kumar, Ellen Marciniak, Janaki Deepak
{"title":"Acute Liver Failure Induced by Joss Paper Ingestion.","authors":"Barathi Sivasailam, Avnee Kumar, Ellen Marciniak, Janaki Deepak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We present a case of liver failure secondary to ingestion of Joss paper. A 44-year-old female initially presented with fever, nausea and vomiting and was subsequently diagnosed with acute liver failure. Prior to presentation she had consumed 1.3 gram of acetaminophen and 800 mg of ibuprofen. Her acetaminophen level was 18 mcg/mL initially and on repeat check was <10 mcg/ml and all viral hepatology antibodies and antigens were negative. History revealed that the patient ingested a ceremonial paper, Joss paper, daily, which is typically painted with heavy metals. Her mercury level was subsequently found to be elevated to 12 ug/L. Mercury can cause depletion of glutathione (GSH) through production of reactive oxygen species. Acetaminophen metabolism requires sufficient GSH to bind to a reactive metabolite to prevent cell death and hepatic injury. Daily exposure to mercury present in the Joss paper, likely accumulated in our patient's body and allowed hepatic injury from even therapeutic doses of acetaminophen.</p>","PeriodicalId":92099,"journal":{"name":"Medical case reports (Wilmington, Del.)","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141731692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case Report of Organizing Pneumonia /IgG4 Related Diseases 组织肺炎/IgG4相关疾病1例报告
Medical case reports (Wilmington, Del.) Pub Date : 2019-01-01 DOI: 10.36648/2471-8041.5.3.126
N. Dogra
{"title":"A Case Report of Organizing Pneumonia /IgG4 Related Diseases","authors":"N. Dogra","doi":"10.36648/2471-8041.5.3.126","DOIUrl":"https://doi.org/10.36648/2471-8041.5.3.126","url":null,"abstract":"Organizing pneumonia form of idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). Organising pneumonia is defined pathologically by the presence in the distal air spaces of buds of granulation tissue progressing from fibrin exudates to loose collagen containing fibroblasts. Since organising pneumonia is a non-specific inflammatory pulmonary process, it may result from a number of causes. Pathologists may report features of organising pneumonia in association with conditions such as infectious pneumonia, lung abscess, empyema, lung cancer, bronchiectasis, broncholithiasis, chronic pulmonary fibrosis, aspiration pneumonia (giant cells and foreign bodies usually are present), adult respiratory distress syndrome, pulmonary infarction, and middle lobe syndrome. This is an interesting, yet challenging case trying to formulate a diagnosis of a patient presented with worsening of dyspnea over more than a year. The patient has history of unsuccessful treatment of eosinophilic asthma with biological agents while also on treatment with prednisone for query organizing pneumonia.","PeriodicalId":92099,"journal":{"name":"Medical case reports (Wilmington, Del.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.36648/2471-8041.5.3.126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69703732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral Uveitis and Keratitis Following Nivolumab Treatment for Metastatic Melanoma. 纳武单抗治疗转移性黑色素瘤后的双侧葡萄膜炎和角膜炎。
Medical case reports (Wilmington, Del.) Pub Date : 2017-01-01 Epub Date: 2017-04-14 DOI: 10.21767/2471-8041.100044
Douglas M Baughman, Cecilia S Lee, Brian E Snydsman, Hoon C Jung
{"title":"Bilateral Uveitis and Keratitis Following Nivolumab Treatment for Metastatic Melanoma.","authors":"Douglas M Baughman,&nbsp;Cecilia S Lee,&nbsp;Brian E Snydsman,&nbsp;Hoon C Jung","doi":"10.21767/2471-8041.100044","DOIUrl":"https://doi.org/10.21767/2471-8041.100044","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory eye disease has been reported as a side effect with Nivolumab.</p><p><strong>Case presentation: </strong>We report a case of a 92-year-old woman presenting with bilateral and simultaneous keratitis and uveitis in the setting of recurring infusions of nivolumab for metastatic melanoma. The patient underwent successful coordinated treatment of both eyes coinciding with ongoing systemic infusion treatments with ophthalmic topical medications alone.</p><p><strong>Conclusion: </strong>The interest of this case resides in the simultaneous nature of presentation of eye inflammation both internally and of the ocular surface. Prior case reports have cited uveitis or ocular surface disease, however not in simultaneous fashion. Clinicians should raise their index of suspicion of side effects of nivolumab systemic infusion for any vision or eye symptom changes around the timing of treatment.</p>","PeriodicalId":92099,"journal":{"name":"Medical case reports (Wilmington, Del.)","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2471-8041.100044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35312072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
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