Nikhil K Khankari, Patrick T Bradshaw, Susan E Steck, Ka He, Andrew F Olshan, Jiyoung Ahn, Mary Beth Terry, Katherine D Crew, Susan L Teitelbaum, Alfred I Neugut, Regina M Santella, Marilie D Gammon
{"title":"Interaction between polyunsaturated fatty acids and genetic variants in relation to breast cancer incidence.","authors":"Nikhil K Khankari, Patrick T Bradshaw, Susan E Steck, Ka He, Andrew F Olshan, Jiyoung Ahn, Mary Beth Terry, Katherine D Crew, Susan L Teitelbaum, Alfred I Neugut, Regina M Santella, Marilie D Gammon","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Higher intake of ω-3 relative to ω-6 polyunsaturated fatty acids (PUFAs) may reduce breast carcinogenesis via different metabolic pathways. The PUFA-breast cancer association remains inconclusive, thus, we hypothesized that interactions between the ratio of dietary ω-3:ω-6 intake and polymorphisms from PUFA-related metabolic pathways would help elucidate an association. Utilizing resources from the Long Island Breast Cancer Study Project, a population-based case-control study (n=1035 cases/1075 controls), we examined interactions between ω-3:ω-6 ratio and 18 polymorphisms of 15 genes. Compared to the putative lowest risk group (high ω-3:ω-6,low-risk <i>FASL</i> rs763110 CT/TT genotype), the odds ratio (OR) for breast cancer from unconditional logistic regression models was weakly increased for other exposure-genotype combinations (high ω-3:ω-6,high-risk <i>FASL</i> CC genotype, OR=1.18,95% confidence interval(CI)=0.90,1.53; low ω-3:ω-6,CT/TT genotype, OR=1.35,95%CI=1.09,1.66); but was approximately null for the putative highest risk group (low ω-3:ω-6,CC genotype; OR=1.06,95%CI=0.81,1.38). We observed an interaction between the ω-3:ω-6 ratio and <i>FASL</i> rs763110 on the additive scale [Relative Excess Risk Due to Interaction(RERI)=-0.47, 95%CI=-0.92,-0.02]. Interactions with other polymorphisms considered were not evident. Our findings suggest that the PUFA-breast cancer association may be modified by <i>FASL</i>. However, additional research is needed given this interaction may be due to chance and is inconsistent with our <i>a priori</i> biologic hypothesis.</p>","PeriodicalId":92066,"journal":{"name":"Journal of cancer epidemiology and prevention (iMedPub)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621474/pdf/nihms-846595.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35466454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}