International journal of nanomedicine and nanosurgery最新文献

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Targeting Cancer using Polymeric Nanoparticle mediated Combination Chemotherapy 靶向肿瘤的聚合纳米颗粒联合化疗
International journal of nanomedicine and nanosurgery Pub Date : 2016-07-04 DOI: 10.16966/2470-3206.116
Aniket P. Gad, Janel L. Kydd, B. Piel, P. Rai
{"title":"Targeting Cancer using Polymeric Nanoparticle mediated Combination Chemotherapy","authors":"Aniket P. Gad, Janel L. Kydd, B. Piel, P. Rai","doi":"10.16966/2470-3206.116","DOIUrl":"https://doi.org/10.16966/2470-3206.116","url":null,"abstract":"Cancer forms exhibiting poor prognosis have been extensively researched for therapeutic solutions. One of the conventional modes of treatment, chemotherapy shows inadequacy in its methodology due to imminent side-effects and acquired drug-resistance by cancer cells. However, advancements in nanotechnology have opened new frontiers to significantly alleviate collateral damage caused by current treatments via innovative delivery techniques, eliminating pitfalls encountered in conventional treatments. Properties like reduced drug-clearance and increased dose efficacy by the enhanced permeability and retention effect deem nanoparticles suitable for this application. Optimization of size, surface charge and surface modifications have provided nanoparticles with stealth properties capable of evading immune responses, thus deeming them as excellent carriers of chemotherapeutic agents. Biocompatible and biodegradable forms of polymers enhance the bioavailability of chemotherapeutic agents, and permit a sustained and time-dependent release of drugs which is a characteristic of their composition, thereby providing a controlled therapeutic approach. Studies conducted in vitro and animal models have also demonstrated a synergism in cytotoxicity given the mechanism of action of anticancer drugs when administered in combination providing promising results. Combination therapy has also shown implications in overcoming multiple-drug resistance, which can however be subdued by the adaptable nature of tumor microenvironment. Surface modifications with targeting moieties can therefore feasibly increase nanoparticle uptake by specific receptor-ligand interactions, increasing dose efficacy which can seemingly overcome drug-resistance. This article reviews recent trends and investigations in employing polymeric nanoparticles for effectively delivering combination chemotherapy, and modifications in delivery parameters enhancing dose efficacy, thus validating the potential in this approach for anticancer treatment.","PeriodicalId":91711,"journal":{"name":"International journal of nanomedicine and nanosurgery","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67392960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 38
Intracellular Photodynamic Activity of Chlorin e6 Containing Nanoparticles. 含氯e6纳米颗粒的细胞内光动力学活性。
International journal of nanomedicine and nanosurgery Pub Date : 2016-01-01 Epub Date: 2016-11-17 DOI: 10.16966/2470-3206
Thomas Hopkins, Rahil Ukani, Raoul Kopelman
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引用次数: 2
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