American journal of virology最新文献

筛选
英文 中文
The Practical Consideration of Poliovirus as an Oncolytic Virotherapy 脊髓灰质炎病毒作为溶瘤病毒疗法的现实考虑
American journal of virology Pub Date : 2016-03-03 DOI: 10.3844/ajvsp.2016.1.7
Elizabeth Denniston, H. Crewdson, Nicole Rucinsky, Andrew Stegman, Diana Remenar, Katherine Moio, B. Clark, Alexandra Higginbotham, Ross Keffer, S. Brammer, Joseph Horzempa
{"title":"The Practical Consideration of Poliovirus as an Oncolytic Virotherapy","authors":"Elizabeth Denniston, H. Crewdson, Nicole Rucinsky, Andrew Stegman, Diana Remenar, Katherine Moio, B. Clark, Alexandra Higginbotham, Ross Keffer, S. Brammer, Joseph Horzempa","doi":"10.3844/ajvsp.2016.1.7","DOIUrl":"https://doi.org/10.3844/ajvsp.2016.1.7","url":null,"abstract":"The inauguration of novel treatment strategies into the clinical setting faces a number of hurdles. In addition to treatment efficacy and safety, acceptance by doctors and patients is paramount to the success of novel therapies. Although viruses are the cause of numerous infectious diseases, these acellular entities have been harnessed over the years to benefit mankind. Recently, a recombinant Poliovirus-Rhinovirus Chimera (PVSRIPO) has shown promise for the treatment of glioblastoma in clinical trials as well as other cancer types in animal models. In this literature review, we discuss the use of PVSRIPO as an oncolytic virotherapy. In addition to being a potential treatment for glioblastoma, this recombinant virus could possibly be used against other cancers because many tumor cells express the PVSRIPO receptor antigens (CD155) and have a limited ability to control viral replication. Moreover, virus-induced immune responses contribute to the efficacy of PVSRIPO. Given the current trajectory of this experimental therapy, the possibility exists that PVSRIPO will soon be a viable treatment option for various cancer types. While many healthcare providers and cancer patients likely welcome this new viral based treatment, history has taught us that some may be skeptical and avoid its use because of the viral composition of this therapy.","PeriodicalId":91653,"journal":{"name":"American journal of virology","volume":"24 1","pages":"1 - 7"},"PeriodicalIF":0.0,"publicationDate":"2016-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90555518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信