Progress in stem cell最新文献

{"title":"The Effect of the Dental Stem Cell Secretome on Tissue Regeneration: A Systematic Review","authors":"Nusaibah Sakinah Nordin, M. Dasor, F. Ariffin, Zurairah Berahim, Muhammad Huzaimi Haron","doi":"10.15419/psc.v9i1-2.413","DOIUrl":"https://doi.org/10.15419/psc.v9i1-2.413","url":null,"abstract":"","PeriodicalId":91602,"journal":{"name":"Progress in stem cell","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44767999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L-ascorbic acid-2-phosphate and Fibrin Substrate Enhances the Chondrogenic Differentiation of Human Adipose-derived Stem Cells","authors":"I. Rosadi, K. Karina, V. D. Kharisma, A. Ansori","doi":"10.15419/psc.v8i2.412","DOIUrl":"https://doi.org/10.15419/psc.v8i2.412","url":null,"abstract":"","PeriodicalId":91602,"journal":{"name":"Progress in stem cell","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45683265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induced pluripotent stem cells are Japanese brand sources for therapeutic cells to pretrial clinical research","authors":"Rupendra Shrestha","doi":"10.15419/psc.v7i1.409","DOIUrl":"https://doi.org/10.15419/psc.v7i1.409","url":null,"abstract":"iPSCs are promising and have potential benefits for medical use, understanding human organogenesis, and cell therapy for advanced diseases. iPSCs are derived pluripotent cells which can further differentiate into functional human cell-lineages, such as neuronal, epithelial cells, cardiac cell, immune cell, and blood cells, etc. Thirteen years on, the discovery of iPSC has revolutionized the field of regenerative medicine, and also the number of clinical studies using iPSC has been growing rapidly worldwide. However, Japan is leading the race of iPSC-based studies and clinical trials due to government support. The Japanese government implemented the world’s fastest approval system and set to host first pretrial clinical studies using iPSC derived therapeutic products. Also, multinational companies of Japan are investing enormously in iPSC-based research for mobilization of iPSC-derived regenerative products to the research institution globally. This review presents an overview of iPSCs, potential benefits, commercialization of iPSC, iPSC-based pretrial clinical studies, and iPSC biobanking in Japan.","PeriodicalId":91602,"journal":{"name":"Progress in stem cell","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47608990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal stem cells transplantation reduces diabetic nephropathy","authors":"Abeer Kazmi, Arsheema Kazmi, Wali Muhammad, M. Azhar","doi":"10.15419/PSC.V6I1.403","DOIUrl":"https://doi.org/10.15419/PSC.V6I1.403","url":null,"abstract":"Diabetes mellitus is a metabolic disease in which the pancreas is unable to produce enough insulin due to the destruction of b -cells or the body does not utilize insulin properly. Continuous fluctuation of blood glucose levels is responsible for prolonged complications such as diabetic nephropathy (DN), diabetic retinopathy, or diabetic cardiomyopathy. Approximately, 20-30% of all diabetic patients face DN, which causes the formation of diabetic glomerular lesions and reduced glomerular filtration rate. In the case of renal failure, kidney transplantation is the only available therapy, however, it is expensive and almost unattainable due to unavailability of donors and host immune rejection. Stem cells are an alternative and attractive source of therapy because of their proliferative nature and the ability to produce distinct specialized cells. Mesenchymal stem cells (MSCs), which are derived from bone marrow, possess an anti-inflammatory property and the ability of selfrenewal and differentiation into a variety of specialized cells. MSCs are widely used to treat different diseases including DN and they have shown encouraging outcomes. This review provides details about the regenerative efficiency of using MSCs in treating diabetic nephropathy.","PeriodicalId":91602,"journal":{"name":"Progress in stem cell","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42484956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demons resurrected from Angels! What are or are not the molecular clues of the rising of the teratoma or teratocarcinoma from human amniotic stem cell?","authors":"M. S. Rahman, Madhuri Haque, S. Asaduzzaman","doi":"10.7603/S40855-015-0002-1","DOIUrl":"https://doi.org/10.7603/S40855-015-0002-1","url":null,"abstract":"","PeriodicalId":91602,"journal":{"name":"Progress in stem cell","volume":"2 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2015-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7603/S40855-015-0002-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71373786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting asthma pathogenesis through study of patterns of cellular traffic indicative of molecular switches operative in inflammation.","authors":"Ena Ray Banerjee","doi":"10.7603/s40855-015-0001-2","DOIUrl":"https://doi.org/10.7603/s40855-015-0001-2","url":null,"abstract":"<p><strong>Background: </strong>Inflammation and degeneration are the two edged swords that impale a pulmonary system with the maladies like asthma and idiopathic pulmonary fibrosis. To explore critical role players that orchestrate the etiology and pathogenesis of these diseases, we used various lung disease models in mice in specific genetic knockout templates.</p><p><strong>Materials and methods: </strong>Acute and chronic allergic asthma and idiopathic pulmonary fibrosis model in mouse was developed in various genetic knockout templates namely α4^{Δ/ Δ}(α41-/-), β2-/-, and α4-/- β2 mice, and the following parameters were measured to assess development of composite asthma phenotype- (i) airway hyperresponsiveness to methacholine by measuring lung resistance and compliance by invasive and P_enh by non-invasive plethysmography as well as lung resistance and compliance using invasive plethysmography, (ii) <i>in situ</i> inflammation status in lung parenchyma and lung interstitium and also resultant airway remodelling measured by histochemical staining namely Masson's Trichrome staining and Hematoxylin&Eosin staining, (iii) formation of metaplastic goblet cells around lung airways by Alcian blue dye, (iv) measurement of Th1 and Th2 cytokines in serum and bronchoalveolar lavage fluid (BALf), (v) serum allergen-specific IgE. Specifically, ovalbumin-induced acute allergic asthma model in mice was generated in WT (wildtype) and KO (knockout) models and readouts of the composite asthma phenotype viz. airway hypersensitivity, serum OVA-specific IgE and IgG, Th2 cytokine in bronchoalveolar lavage fluid (BALf) and lymphocyte cell subsets viz. T, B cells, monocytes, macrophages, basophils, mast cells and eosinophils (by FACS and morphometry in H&E stained cell smears) were assessed in addition to lung and lymph node histology.</p><p><strong>Results: </strong>We noticed a pattern of cellular traffic between bone marrow (BM)→ peripheral blood (PB) → lung parenchyma (LP) → (BALf) in terms of cellular recruitment of key cell sub-types critical for onset and development of the diseases which is different for maintenance and exacerbations in chronic cyclically occurring asthma that leads to airway remodelling. While inflammation is the central theme of this particular disease, degeneration and shift in cellular profile, subtly modifying the clinical nature of the disease were also noted. In addition we recorded the pattern of cell movement between the secondary lymphoid organs namely, the cervical, axillary, ingunal, and mesenteric lymph nodes vis-à-vis spleen and their sites of poiesis BM, PB and lung tissue. While mechanistic role is the chief domain of the integrins (α4 i.e. VLA-4 or α4β1, VCAM-1; β2 i.e. CD18 or ICAM-1).</p><p><strong>Concluding remarks: </strong>The present paper thoroughly compares and formulates the pattern of cellular traffic among the three nodes of information throughput in allergic asthma immunobiology, namely, prima","PeriodicalId":91602,"journal":{"name":"Progress in stem cell","volume":"2 ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7603/s40855-015-0001-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34746442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Progress in Stem Cell Chondrogenesis","authors":"W. Toh","doi":"10.7603/S40855-014-0003-5","DOIUrl":"https://doi.org/10.7603/S40855-014-0003-5","url":null,"abstract":"","PeriodicalId":91602,"journal":{"name":"Progress in stem cell","volume":"1 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2014-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7603/S40855-014-0003-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71373781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Defined Neural Cell Populations as a Possible Solution for Challenges in Neural Stem Cell Therapy","authors":"H. Azari","doi":"10.7603/S40855-014-0002-6","DOIUrl":"https://doi.org/10.7603/S40855-014-0002-6","url":null,"abstract":"","PeriodicalId":91602,"journal":{"name":"Progress in stem cell","volume":"1 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2014-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7603/S40855-014-0002-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71373775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Welcome to Progress in Stem Cell","authors":"P. Pham, N. Phan","doi":"10.7603/S40855-014-0001-7","DOIUrl":"https://doi.org/10.7603/S40855-014-0001-7","url":null,"abstract":"","PeriodicalId":91602,"journal":{"name":"Progress in stem cell","volume":"1 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2014-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7603/S40855-014-0001-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71373770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}