Journal of schizophrenia research最新文献

{"title":"A Pilot Investigation of the Use of Positive Psychotherapy for People with a First Episode of Psychosis","authors":"M. K, Mc Carthy O","doi":"10.26420/jschizophrres.2023.1044","DOIUrl":"https://doi.org/10.26420/jschizophrres.2023.1044","url":null,"abstract":"Objective: Mental health services are placing a greater emphasis on wellbeing and recovery. Services are also prioritizing the early intervention for people with psychosis in order to support mental health and to reduce the negative impact on the person’s life. Positive Psychotherapy is the therapy that directly cultivates subjective wellbeing and it also aligns with attaining personal recovery. Method: A pilot single case experimental design investigated the use of Positive Psychotherapy for people with a first episode of psychosis. Five people (2 males, 3 females) aged between 20 and 47 years, were recruited from the North Dublin Mental Health Services. Results: Positive Psychotherapy was found to be an acceptable therapy with all of the participants completing the intervention. Some improvements were noted within the daily recording of subjective wellbeing, yet the effect of the intervention was not replicated throughout participants. However, there were differences in relation to how people with higher and lower levels of distress experience Positive Psychotherapy. The findings on the standardized wellbeing measures indicate that people recovering from psychosis can attain subjective wellbeing and to the same level as that recorded within the general population. There was clearly a greater drop in participants’ level of distress than an increase in wellbeing on the standardized measures. It may therefore be that distress and wellbeing are distinctive constructs. Reliable change occurred within more people on the clinical measure of distress than on the wellbeing measures, with clinically significant change occurring within most participants. All of the participants’ level of functioning also increased following the intervention. It is recommended for future interventions to align people presenting with similar levels of: distress, wellbeing and features of psychosis. It is also suggested to investigate the links or otherwise between the constructs and the mechanisms underpinning the therapy. Conclusion: There is initial evidence that Positive Psychotherapy is beneficial to the mental health of people recovering from psychosis. This is particularly evident on the standardized clinical measure of distress and in terms of increasing people’s levels of functioning. However, further refined research is clearly warranted.","PeriodicalId":91559,"journal":{"name":"Journal of schizophrenia research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42889004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Schizophrenia Variant V1282F in SCN2A Causes Functional Impairment of NaV1.2","authors":"B. Kohlnhofer, Y. Liu, G. Woodruff, T. Lovenberg, P. Bonaventure, Harrington Aw","doi":"10.26420/JSCHIZOPHRRES.2021.1038","DOIUrl":"https://doi.org/10.26420/JSCHIZOPHRRES.2021.1038","url":null,"abstract":"Neuropsychiatric disorders such as schizophrenia are challenging to treat due to the biological complexity of the disease and the lack of knowledge of the underlying pathophysiology. Whole exome and genome sequencing studies have identified disease-linked rare variants in patients with large effect size. Here, we functionally characterize the schizophrenia linked variant V1282F in SCN2A, encoding the sodium channel Nav1.2. This variant was introduced into isogenic lines of hiPSCs using CRISPR/CAS9 genome editing tools. hiPSCs were then differentiated into cortical neurons to understand how the variant and gene may be contributing to disease. We observed a significant (~25%) decrease in sodium current in the V1282F neurons compared to control neurons, suggesting the mutation is causing a loss-of-channel function. These results were supported by recordings in recombinant cells overexpressing either the mutant or wildtype Nav1.2, with the mutant channel having significantly (~75%) lower current amplitude than wildtype. We hypothesize that this phenotype may contribute to disease either through the direct loss of neuronal activity or through subsequent abnormal neurodevelopment.","PeriodicalId":91559,"journal":{"name":"Journal of schizophrenia research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44342854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self, Voices and Embodiment: A Phenomenological Analysis.","authors":"C Rosen,&nbsp;N Jones,&nbsp;K A Chase,&nbsp;L S Grossman,&nbsp;H Gin,&nbsp;R P Sharma","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The primary aim of this study was to examine first-person phenomenological descriptions of the relationship between the self and Auditory Verbal Hallucinations (AVHs). Complex AVHs are frequently described as entities with clear interpersonal characteristics. Strikingly, investigations of first-person (subjective) descriptions of the phenomenology of the relationship are virtually absent from the literature.</p><p><strong>Method: </strong>Twenty participants with psychosis and actively experiencing AVHs were recruited from the University of Illinois at Chicago. A mixed-methods design involving qualitative and quantitative components was utilized. Following a priority-sequence model of complementarity, quantitative analyses were used to test elements of emergent qualitative themes.</p><p><strong>Results: </strong>The qualitative analysis identified three foundational constructs in the relationship between self and voices: 'understanding of origin,' 'distinct interpersonal identities,' and 'locus of control.' Quantitative analyses further supported identified links of these constructs. Subjects experienced their AVHs as having identities distinct from self and actively engaged with their AVHs experienced a greater sense of autonomy and control over AVHs.</p><p><strong>Discussion: </strong>Given the clinical importance of AVHs and emerging strategies targeting the relationship between the hearer and voices, our findings highlight the importance of these relational constructs in improvement and innovation of clinical interventions. Our analyses also underscore the value of detailed voice assessments such as those provided by the Maastricht Interview are needed in the evaluation process. Subjects narratives shows that the relational phenomena between hearer and AVH(s) is dynamic, and can be influenced and changed through the hearers' engagement, conversation, and negotiation with their voices.</p>","PeriodicalId":91559,"journal":{"name":"Journal of schizophrenia research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834921/pdf/nihms775124.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34478678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate Cancer Related JAZF1 Gene is Associated with Schizophrenia.","authors":"Ke-Sheng Wang,&nbsp;Lingjun Zuo,&nbsp;Daniel Owusu,&nbsp;Yue Pan,&nbsp;Xingguang Luo","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Epidemiological studies have shown that there is a reduced risk of prostate cancer among persons diagnosed with schizophrenia (SCZ). However, the mechanism of such relationship is not clear. The reduced incidence of cancer observed in SCZ patients may be related to differences in genetic background. Recently, the JAZF1 gene is found to be associated with prostate cancer and type 2 diabetes. However, no study has focused on the association of JAZF1 with the risk of SCZ.</p><p><strong>Methods: </strong>We examined genetic associations of 118 single-nucleotide polymorphisms (SNPs) within the JAZF1 gene with SCZ using one European American (EA) sample of 1,149 cases and 1,347 controls. Logistic regression analysis of SCZ as a binary trait was performed using PLINK software.</p><p><strong>Results: </strong>The most significant association with SCZ was observed with rs10258132 (p = 0.0011); while the next best signal was rs17156259 (p = 0.0031). The third best associated SNP was rs7791865 (p = 0.00889). In addition, haplotype analyses revealed that the A-C haplotype from rs10244184 and rs10258132 was associated with SCZ (p = 0.00093); and the G-G haplotype from rs17156238 and rs17156259 was associated with SCZ (p = 0.00455).</p><p><strong>Conclusion: </strong>These findings provide evidence of several genetic variants in JAZF1 gene influencing the risk of SCZ and will serve as a resource for replication in other populations.</p>","PeriodicalId":91559,"journal":{"name":"Journal of schizophrenia research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996122/pdf/nihms811098.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34701961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}