International journal of pharma sciences最新文献

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The case control studies of HIV and Intestinal parasitic infections rate in active pulmonary tuberculosis patients in Woldia General Hospital and Health Center in North Wollo, Amhara Region, Ethiopia. 对埃塞俄比亚阿姆哈拉地区北沃尔洛的沃尔迪亚综合医院和保健中心活动性肺结核患者的艾滋病毒和肠道寄生虫感染率进行病例对照研究。

International journal of pharma sciences Pub Date : 2015-05-01 Epub Date: 2015-06-10

Ambachew Woreta Hailu, Solomon G/Selassie, Yared Merid, Addis Adera Gebru, Yonas Yimam Ayene, Markos Kidane Asefa

{"title":"The case control studies of HIV and Intestinal parasitic infections rate in active pulmonary tuberculosis patients in Woldia General Hospital and Health Center in North Wollo, Amhara Region, Ethiopia.","authors":"Ambachew Woreta Hailu, Solomon G/Selassie, Yared Merid, Addis Adera Gebru, Yonas Yimam Ayene, Markos Kidane Asefa","doi":"","DOIUrl":"","url":null,"abstract":"Tuberculosis remains a major health problem worldwide in the era of HIV/AIDS. Co-infection with intestinal parasites has been suggested to worsen the outcome of infection in addition to HIV infection. Hence, adequate information on TB patients with HIV and intestinal parasites infection is being needed to tackle the problem, undertake the integrated prevention and control program. This study was aimed to assess the prevalence of HIV and intestinal parasitic infections in active pulmonary tuberculosis patients compared with their healthy extended family of the subject as a control. A case-control study was carried out from November, 2010 to June, 2011 in Woldia General Hospital and Woldia Health Center. Stool sample were examined using direct technique and formol-ether concentration techniques. Modified acid fast stain was used to identify Oocysts of Cryptosporidium species and Isospora belli. HIV rapid tests were used to screen sero prevalence and AFB smear microscopy for screening Pulmonary TB patients. A total of 100 smear positive TB patients and 168 familial contacts were participated and the overall prevalence of intestinal parasite among TB patients was 49%; compared to 23.2% of the control. 41% of TB patients and 23.8% controls were found to be HIV infected. Double infection with both intestinal parasite and HIV was found in 61% TB patients and 52.5% of the controls. The proportions of TB patients infected with 1, 2, or more species of worms were 73.5%, 26.5% respectively; 82%, 18% were in controls and the odds of being an active TB patient is increased with the number of species of intestinal parasites the person harbors. The current study showed that a significant association between TB/HIV infection and intestinal parasite particularly Strongyloides stercoralis Cryptosporidium parvum and Isospora belli.","PeriodicalId":91295,"journal":{"name":"International journal of pharma sciences","volume":"5 3","pages":"1092-1099"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140208468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Formulation and Characterization of Orally Dissolving Thin Films containing the German cockroach Blatella germanica (Bla g 2) Allergen. 含德国小蠊(blag2)变应原的口服溶解薄膜的制备与表征。

International journal of pharma sciences Pub Date : 2014-09-01

Qingqing Chen, Russell Martin, Stephen W Hoag, Robert A Wood, Hai-Quan Mao, Corinne Keet

{"title":"Formulation and Characterization of Orally Dissolving Thin Films containing the German cockroach Blatella germanica (Bla g 2) Allergen.","authors":"Qingqing Chen, Russell Martin, Stephen W Hoag, Robert A Wood, Hai-Quan Mao, Corinne Keet","doi":"","DOIUrl":"","url":null,"abstract":"Allergy and asthma are among the most common chronic diseases of childhood. Cockroach allergy is an important contributor to asthma morbidity, with a prevalence of 17 to 41%. Immunotherapy has been shown to be an effective treatment for other allergies that contribute to asthma, but several factors have limited its use for cockroach allergy. In this work, a sublingual immunotherapy (SLIT) formulation of orally dissolving thin film has been developed for the treatment of hypersensitivity to the German cockroach Bla g 2 allergen. The formulation allows for the incorporation of up to 25 μg/film of the allergen protein, and the film's mucoadhesiveness prolongs the effect of the allergen with the potential for enhanced efficacy. The potency and dose uniformity of the SLIT formulation were characterized by enzyme-linked immunosorbent assay (ELISA), and other physicochemical properties were evaluated by spectroscopic or mechanistic methods. The films were uniform in weight and thickness, and demonstrated substantial physical strength to allow easy manipulation during manufacturing and dosing. The dosage uniformity, in vitro disintegration and in vitro dissolution profiles of the films were within the acceptance criteria in the United States Pharmacopeia. The developed SLIT methodology possesses the potential to significantly improve immunotherapy for both food and inhalant allergies in adults and children.","PeriodicalId":91295,"journal":{"name":"International journal of pharma sciences","volume":"4 5","pages":"730-735"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38894284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0